Cellular Plasticity in the Brain: discovering molecular mechanisms controlling the production of neurons during brain development, function, ageing and disease. The program aims to understand the mechanisms regulating Brain Plasticity - this recently discovered property of the brain to respond to environmental stimuli, both physiological and pathological, by producing new functional neurons. Specifically, the program will discover how the brain's stem cells are stimulated to produce new neurons. ....Cellular Plasticity in the Brain: discovering molecular mechanisms controlling the production of neurons during brain development, function, ageing and disease. The program aims to understand the mechanisms regulating Brain Plasticity - this recently discovered property of the brain to respond to environmental stimuli, both physiological and pathological, by producing new functional neurons. Specifically, the program will discover how the brain's stem cells are stimulated to produce new neurons. This understanding will significantly expand our knowledge of how the brain develops, and how functions, like memory, are modulated by neuronal replacement. Discoveries will underpin the development of, in association with Australia's biotechnology sector, a new generation of therapeutics, which treat neurological diseases, like Stroke, by stimulating the production of functional neurons.Read moreRead less
Stimulus fear-relevance: Exploring the boundaries of preferential attentional processing. The present project will contribute to our knowledge about the manner in which emotionally salient events are processed. It will test predictions from a current, influential theory of anxiety and in doing so, inform our understanding of information processing in psychopathology. Investigation of these basic questions can have implications for the design of therapeutic interventions. Moreover, the presen ....Stimulus fear-relevance: Exploring the boundaries of preferential attentional processing. The present project will contribute to our knowledge about the manner in which emotionally salient events are processed. It will test predictions from a current, influential theory of anxiety and in doing so, inform our understanding of information processing in psychopathology. Investigation of these basic questions can have implications for the design of therapeutic interventions. Moreover, the present project will provide the opportunity for research training for undergraduate and post graduate students. In doing so, it will enhance the quality of our culture and contribute to the discipline of psychology.Read moreRead less
Testing the ghost with the machine: Empirical investigations of cognition using high-field functional magnetic resonance imaging. The primary aim of the project is to test hypotheses about the cognitive architecture of word production and negative priming using high-field functional magnetic resonance imaging (fMRI). Additional aims/outcomes are to apply a novel fMRI acquisition sequence that permits overt verbal responding with rapid presentation of trials and collection of the time course of t ....Testing the ghost with the machine: Empirical investigations of cognition using high-field functional magnetic resonance imaging. The primary aim of the project is to test hypotheses about the cognitive architecture of word production and negative priming using high-field functional magnetic resonance imaging (fMRI). Additional aims/outcomes are to apply a novel fMRI acquisition sequence that permits overt verbal responding with rapid presentation of trials and collection of the time course of the blood oxygen level dependent (BOLD) signal, and to further develop a methodology that delineates the logic of making inferences about cognitive systems from functional neuroimaging data. These represent potentially significant developments in the fields of cognitive neuroscience and functional neuroimaging.Read moreRead less
Mechanisms of fear learning and extinction in the mammalian brain. The brain is a remarkable machine that coordinates all aspects of our daily lives including the storage and retrieval of memories. Given that many age-related degenerative disorders are associated with marked changes in learning and memory it also has implications for Australia's National Research Priority 2 "Ageing well and ageing productively". This research aims to discover the basic mechanisms that underlie memory storage an ....Mechanisms of fear learning and extinction in the mammalian brain. The brain is a remarkable machine that coordinates all aspects of our daily lives including the storage and retrieval of memories. Given that many age-related degenerative disorders are associated with marked changes in learning and memory it also has implications for Australia's National Research Priority 2 "Ageing well and ageing productively". This research aims to discover the basic mechanisms that underlie memory storage and how these are modulated in an emotional context. It will also shed light on states such as anxiety, depression and post-traumatic stress, enhancing our ability to identify new therapeutic targets for such disorders.Read moreRead less
The Evolution of the Social Brain: How Emotions and Moral Judgement Interact in the Generation of Cooperative Behaviour. Understanding the psychological forces that underpin human interactions is a necessary step to knowing how to improve those interactions. Comprehending the complex interplay of emotions and moral judgements lying behind decision-making in the social sphere will help explain such things as corruption, risk-taking, domestic violence, and political affiliation. Such knowledge can ....The Evolution of the Social Brain: How Emotions and Moral Judgement Interact in the Generation of Cooperative Behaviour. Understanding the psychological forces that underpin human interactions is a necessary step to knowing how to improve those interactions. Comprehending the complex interplay of emotions and moral judgements lying behind decision-making in the social sphere will help explain such things as corruption, risk-taking, domestic violence, and political affiliation. Such knowledge can guide the design of effective social policy, and is vital for a realistic educational strategy. This project will strengthen Australia's excellent reputation in philosophy, bring here leading scholars from diverse fields, build international research networks, and in particular forge an ongoing partnership between the ANU and the California Institute of Technology.Read moreRead less
How Stenolemus Assassin Bugs Crack Spider Codes. This unique study of sophisticated behavioural flexibility and dynamic sensory exploitation in an insect will provide novel insights into how simple cognitive architecture can be used to solve complex problems. These insights are important for the development of artificial intelligence systems. This will be the first study of flexible aggressive mimicry in an insect and will attract considerable international attention, raise the profile of Austra ....How Stenolemus Assassin Bugs Crack Spider Codes. This unique study of sophisticated behavioural flexibility and dynamic sensory exploitation in an insect will provide novel insights into how simple cognitive architecture can be used to solve complex problems. These insights are important for the development of artificial intelligence systems. This will be the first study of flexible aggressive mimicry in an insect and will attract considerable international attention, raise the profile of Australian science and support numerous students. We will make the first use in Australia of state-of-the-art vibration recording and interactive playback techniques. Making these powerful experimental tools available in Australia will enable other many additional innovative lines of research.Read moreRead less
Genetic control of plant organ growth. Plants organs, such as leaves and petals, have a distinct size and shape reflecting differences in growth. Despite its importance, very little is known about the mechanisms that regulate growth. The objectives of this proposal are a) to test whether organ growth depends on cell-cell signalling and b) to identifying genes that regulate growth, and to characterize their molecular function.
Biased information processing in anxiety: Low anxiety scores, but still at risk. Information processing in anxious persons is biased if confronted with threatening stimulus materials such as words or pictures. This finding has considerable implications for our understanding of fear acquisition and maintenance and for the design of therapeutic interventions. More recent research has shown, however, that low anxious persons who employ repressive coping styles show similar biases. The present proj ....Biased information processing in anxiety: Low anxiety scores, but still at risk. Information processing in anxious persons is biased if confronted with threatening stimulus materials such as words or pictures. This finding has considerable implications for our understanding of fear acquisition and maintenance and for the design of therapeutic interventions. More recent research has shown, however, that low anxious persons who employ repressive coping styles show similar biases. The present project will follow up on these findings by combining the expertises of the two CIs in contemporary cognitive and psychophysiological research. It will not only provide new insights, but also offer research opportunities for postgraduate students, and prospects for future collaborative funding.Read moreRead less
Human learning of likes and dislikes: A test of the dual process account and an investigation of its neural substrates. Dual process accounts of human affective learning hold that affective learning, the learning of likes and dislikes, and relational learning, the learning of predictive relationships, reflect separate learning mechanisms. Affective learning, for instance, is said not to extinguish, a claim that has far reaching consequences for the design of behaviourally based treatments of a ....Human learning of likes and dislikes: A test of the dual process account and an investigation of its neural substrates. Dual process accounts of human affective learning hold that affective learning, the learning of likes and dislikes, and relational learning, the learning of predictive relationships, reflect separate learning mechanisms. Affective learning, for instance, is said not to extinguish, a claim that has far reaching consequences for the design of behaviourally based treatments of anxiety. The project will test this and other predictions of dual process accounts. Moreover, it will extent the experimental analysis of affective learning to the acquisition of likes and identify the cortical bases for aversive, appetitive, and relational learning using event related functional magnetic resonance imaging.Read moreRead less
Maturation of the brain and the development of cognitive abilities. This project aims to develop techniques for measuring the growing brain. We will use these techniques to determine how the growing brain influences a child's intellectual ability and to answer an important question - do areas of the brain mature at the same or different rates and what influence does that have on the development of specific abilities such as language and reasoning? An answer to this question will make an import ....Maturation of the brain and the development of cognitive abilities. This project aims to develop techniques for measuring the growing brain. We will use these techniques to determine how the growing brain influences a child's intellectual ability and to answer an important question - do areas of the brain mature at the same or different rates and what influence does that have on the development of specific abilities such as language and reasoning? An answer to this question will make an important contribution to our theoretical understanding of developmental disorders. Moreover, given the influence of intellectual development on life prospects, it is important to understand how early brain development impacts on a child's ability to learn.Read moreRead less