From The Synchrotron To The Clinic: Translation Of A Novel Functional Lung Imaging Technology
Funder
National Health and Medical Research Council
Funding Amount
$891,834.00
Summary
Our team has recently developed a synchrotron technology with a startling capacity for dynamic functional imaging that can act as a sensitive regional indicator of lung disease. We will demonstrate that this technology can be translated from the synchrotron to the lab and eventually the clinic. We will provide proof of this concept by the application of this technology to emphysema, asthma, lung cancer, cystic fibrosis lung disease and neonatal resuscitation.
Stress Evaluation with Non-Linear Guided Waves. This project plans to investigate a novel approach for in situ measurement of stress in structures based on an internal resonance phenomenon for nonlinear guided waves. Monitoring the stress level of critical structural components is important to ensure structural safety. The project plans to derive the requirements for this internal resonance and its dependence on stress analytically and verify them experimentally for both simple waveguides and mo ....Stress Evaluation with Non-Linear Guided Waves. This project plans to investigate a novel approach for in situ measurement of stress in structures based on an internal resonance phenomenon for nonlinear guided waves. Monitoring the stress level of critical structural components is important to ensure structural safety. The project plans to derive the requirements for this internal resonance and its dependence on stress analytically and verify them experimentally for both simple waveguides and more realistic structures. The expected outcome is the demonstration of the feasibility of a new inexpensive method for continuous monitoring of applied or thermally-induced stresses, which is of great importance in several engineering contexts, such as modern railway track rails, pipelines or pre-stressed strands in concrete structures.Read moreRead less
Revolutionising The Diagnosis And Monitoring Of CF Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$818,391.00
Summary
Cystic fibrosis (CF) lung disease starts early in childhood and relentlessly progresses, with early death a common outcome. There is currently no method capable of detecting very early disease onset nor directly assessing the effectiveness of putative treatments. This project will apply our globally unique X-ray imaging tools, which are capable of imaging lung function at any point across the entire lung, for the very early detection of CF and assessment of clinically applicable treatments.
A novel approach to controlling boundary-layer separation. This project will involve fundamental research into the control of the fluid dynamical phenomena of boundary-layer separation and transition to turbulence. The project will be built upon a firm foundation of mathematical modelling of the complex behaviour of fluid flows that are near the onset of flow separation or turbulence. The project will produce results that will permit the development of control strategies that can be implemented ....A novel approach to controlling boundary-layer separation. This project will involve fundamental research into the control of the fluid dynamical phenomena of boundary-layer separation and transition to turbulence. The project will be built upon a firm foundation of mathematical modelling of the complex behaviour of fluid flows that are near the onset of flow separation or turbulence. The project will produce results that will permit the development of control strategies that can be implemented in a wide variety of important technological applications, such as drag reduction in the aerospace and ship industries as well as the control of stall (or loss of lift) in modern aircraft.Read moreRead less
Modelling the capillary entrapment phenomena and integrity of geological reservoirs for clean energy, water and waste management technologies. This project will improve our understanding of non-linear flow and fracture phenomena in porous media which is prerequisite for the development of new emerging technologies targeting the reduction of the greenhouse gas emission and development of effective waste and water management solutions including coal gasification, in-situ storage of natural and non ....Modelling the capillary entrapment phenomena and integrity of geological reservoirs for clean energy, water and waste management technologies. This project will improve our understanding of non-linear flow and fracture phenomena in porous media which is prerequisite for the development of new emerging technologies targeting the reduction of the greenhouse gas emission and development of effective waste and water management solutions including coal gasification, in-situ storage of natural and non-hydrocarbon gases, underground disposal of hazardous wastes and vadose zone remediation. The project will result in a dramatic improvement of the predictive tools for traditional ground water management, irrigation and petroleum recovery applications. It has the strength to place Australia in the forefront of these technologies. Read moreRead less
Robust fluid mixing through topological chaos. The Australian chemicals and plastics industry has an annual turnover of over $20 billion and employs over 77,000 people; fluid mixing is fundamental to this industry, yet the industry is recognised as underinvesting in research and development in this essential area. Furthermore, frontier technologies such as biotechnology and the next generation of smart materials also crucially rely on fluid mixing. This project aims to evaluate a new paradigm ( ....Robust fluid mixing through topological chaos. The Australian chemicals and plastics industry has an annual turnover of over $20 billion and employs over 77,000 people; fluid mixing is fundamental to this industry, yet the industry is recognised as underinvesting in research and development in this essential area. Furthermore, frontier technologies such as biotechnology and the next generation of smart materials also crucially rely on fluid mixing. This project aims to evaluate a new paradigm (topological chaos) for the design of mixers, to provide better and more robust mixers that work from microscopic to industrial scales.Read moreRead less
Damage Tolerance Approach in Designing and Maintaining Truck Trailers. This project aims to develop a damage tolerance approach in designing and maintaining truck trailers. Combined with field test and computational simulation, machine learning will be used to generate loading spectrums. Following the damage tolerance philosophy, a mature approach in aerospace industry, the fatigue crack growth and the fatigue life will be predicted. In addition, structural optimisation will be applied in traile ....Damage Tolerance Approach in Designing and Maintaining Truck Trailers. This project aims to develop a damage tolerance approach in designing and maintaining truck trailers. Combined with field test and computational simulation, machine learning will be used to generate loading spectrums. Following the damage tolerance philosophy, a mature approach in aerospace industry, the fatigue crack growth and the fatigue life will be predicted. In addition, structural optimisation will be applied in trailer design. This project expects to revolutionize the design and maintenance practices in Australian truck trailer industry. It should provide significant benefits, such as prolonging the life cycle of truck trailers, reducing the tare weight and increasing operating profit, to both trailer producers and users.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130101571
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Assimilation of ocean wave interactions with sea ice into climate models. Contemporary climate models do not accurately portray ocean or atmosphere interactions where the open ocean meets the expanses of floating sea ice within the polar regions, as they lack a component to determine the size of ice floes. This project will tackle the omission directly, developing from modelling advances made in recent years.
Systematically model the large-scale complexity of turbulent floods and thin film flows. This project continues development of new models, and computer
simulation, of turbulent flood, river and estuarine flow. The models
will be based systematically upon established turbulence models to
resolve accurately the complex physical processes. The development of
new and robust computer models for thin layers of coating fluid will
aid many industrial processes. We also aim to provide correct ini ....Systematically model the large-scale complexity of turbulent floods and thin film flows. This project continues development of new models, and computer
simulation, of turbulent flood, river and estuarine flow. The models
will be based systematically upon established turbulence models to
resolve accurately the complex physical processes. The development of
new and robust computer models for thin layers of coating fluid will
aid many industrial processes. We also aim to provide correct initial
conditions and boundary conditions for simpler cases of the above
flows. The approach leads to a greater understanding of the range of
applicability of the models through better estimating the errors in the
modelling process. The project develops a fundamental enabling
methodology for engineering and the sciences.
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Discovery Early Career Researcher Award - Grant ID: DE150101647
Funder
Australian Research Council
Funding Amount
$330,000.00
Summary
Symplectic solvmanifolds and their friends. Symplectic geometry is the mathematical foundation of classical mechanics and quantum theory. The symmetry group of a physical system determines the conservation laws governing its behaviour. This project aims to advance the understanding of a large class of these symmetry groups and their associated symplectic geometries, which are called symplectic solvmanifolds. The project aims to: determine the topological properties of symplectic solvmanifolds as ....Symplectic solvmanifolds and their friends. Symplectic geometry is the mathematical foundation of classical mechanics and quantum theory. The symmetry group of a physical system determines the conservation laws governing its behaviour. This project aims to advance the understanding of a large class of these symmetry groups and their associated symplectic geometries, which are called symplectic solvmanifolds. The project aims to: determine the topological properties of symplectic solvmanifolds as encoded in their fundamental groups; their geometric properties in the form of holonomy groups; and the algebraic properties of their symplectic algebras. The project endeavours to classify the building blocks of symplectic geometry.Read moreRead less