A Randomised Controlled Trial Of Interventional Versus Conservative Treatment Of Primary Spontaneous Pneumothorax
Funder
National Health and Medical Research Council
Funding Amount
$412,315.00
Summary
Primary spontaneous pneumothorax (PSP) is a collapsed lung that occurs in otherwise healthy people without underlying lung disease. Current standard treatment is to insert a chest drain into the chest to remove the air around the collapsed lung so that the lung re-inflates rapidly ("interventional treatment"). We will determine whether doing nothing, i.e. letting the lung re-inflate slowly on its own over several weeks ("conservative treatment"), is just as good or even better for patients.
Benefits Of Home-based Multidisciplinary Rehabilitation In Non Small Cell Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$581,039.00
Summary
Lung cancer is the third leading cause of death in Australia. People with lung cancer experience a complex mix of symptoms that can provoke significant distress and impair physical function. This study aims to develop and test a home based exercise and self-management support program to increase function and physical activity levels, reduce levels of depression and improve quality of life of people with lung cancer.
Outmaneuvering correlated noise in quantum computers. The project aims to characterise and control quantum machines available today. These machines overwhelmingly suffer from noise with complex structures. Thus, a key target of the project is to develop a theory to describe and manipulate complex quantum processes. The project then intends to apply this theory to commercial-grade quantum computers. This approach is anticipated to lead to a new understanding of time-correlated complex quantum pro ....Outmaneuvering correlated noise in quantum computers. The project aims to characterise and control quantum machines available today. These machines overwhelmingly suffer from noise with complex structures. Thus, a key target of the project is to develop a theory to describe and manipulate complex quantum processes. The project then intends to apply this theory to commercial-grade quantum computers. This approach is anticipated to lead to a new understanding of time-correlated complex quantum processes and develop methods to enhance the performance of today's quantum computers. Noise characterisation and mitigation should have commercial value and benefit research groups working to develop quantum technologies, both in Australia and internationally.Read moreRead less
Functionally Graded Ultra High Perfomance Concete Structure under Flexure. This project aims to develop a novel multilayer functionally graded concrete structure that is a mixture of normal strength concrete and ultra high performance concrete with the mixing ratio varying in a layer-wise manner, offering a highly cost-effective structural design solution with significantly improved safety and durability over conventional concrete structures. The expected outcomes include the innovative design, ....Functionally Graded Ultra High Perfomance Concete Structure under Flexure. This project aims to develop a novel multilayer functionally graded concrete structure that is a mixture of normal strength concrete and ultra high performance concrete with the mixing ratio varying in a layer-wise manner, offering a highly cost-effective structural design solution with significantly improved safety and durability over conventional concrete structures. The expected outcomes include the innovative design, experimental data on the static and dynamic structural behaviour, development of reliable simulation techniques and optimal design procedures for the proposed structure with greatly reduced material costs. The project will have huge benefits to Australian civil engineering industry and national economy.
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Quantum measurement as a resource. Advanced quantum computers will use modular measurements significantly enhancing their capabilities. However, due to the noisy environment, the measurements may have nontrivial effects on the computation. Making best use of realistic (hence imperfect) measurements is a challenging problem that hinders the development of these technologies. This project, using modern tools of resource theory, aims to design optimal realistic measurement procedures for near-term ....Quantum measurement as a resource. Advanced quantum computers will use modular measurements significantly enhancing their capabilities. However, due to the noisy environment, the measurements may have nontrivial effects on the computation. Making best use of realistic (hence imperfect) measurements is a challenging problem that hinders the development of these technologies. This project, using modern tools of resource theory, aims to design optimal realistic measurement procedures for near-term noisy quantum devices. The expected outcomes of the project are refined methods to optimise quantum measurements in today's rudimentary quantum machines. This will provide a significant benefit to the Australian community, advancing the development of disruptive quantum technologies.Read moreRead less
Damage Tolerance Approach in Designing and Maintaining Truck Trailers. This project aims to develop a damage tolerance approach in designing and maintaining truck trailers. Combined with field test and computational simulation, machine learning will be used to generate loading spectrums. Following the damage tolerance philosophy, a mature approach in aerospace industry, the fatigue crack growth and the fatigue life will be predicted. In addition, structural optimisation will be applied in traile ....Damage Tolerance Approach in Designing and Maintaining Truck Trailers. This project aims to develop a damage tolerance approach in designing and maintaining truck trailers. Combined with field test and computational simulation, machine learning will be used to generate loading spectrums. Following the damage tolerance philosophy, a mature approach in aerospace industry, the fatigue crack growth and the fatigue life will be predicted. In addition, structural optimisation will be applied in trailer design. This project expects to revolutionize the design and maintenance practices in Australian truck trailer industry. It should provide significant benefits, such as prolonging the life cycle of truck trailers, reducing the tare weight and increasing operating profit, to both trailer producers and users.Read moreRead less
Topological Design of Mechanical Meta-Structures. This project aims to establish a new computational design methodology to address current challenges facing creation of ultralight structures with ultra-high-performance characteristics. The latest technologies in structural topology optimization and its correlated numerical simulation and structural analysis methods will be unified towards an integrated design framework. Expected outcomes include an advanced generative design platform for discove ....Topological Design of Mechanical Meta-Structures. This project aims to establish a new computational design methodology to address current challenges facing creation of ultralight structures with ultra-high-performance characteristics. The latest technologies in structural topology optimization and its correlated numerical simulation and structural analysis methods will be unified towards an integrated design framework. Expected outcomes include an advanced generative design platform for discovering novel geometries to underpin new meta-structure architectures, validated by appropriate fabrication techniques considering their geometric complexity. Such capabilities will benefit defence, civil, aerospace, energy and transport industries that pursue competitive advantage through innovation.Read moreRead less
Optimising haemodynamics in complex stented arteries. This project aims to optimise the hemodynamics (blood flow) in coronary arteries with high curvatures and bifurcations. Experience has shown that the build-up of plaque — and the resulting occlusion of blood flow — tends to occur in these complex arterial regions. The most common therapeutic strategy is the insertion of a stent to prop open the artery. However, the nature of the geometry often leads to post-stenting complications such as rest ....Optimising haemodynamics in complex stented arteries. This project aims to optimise the hemodynamics (blood flow) in coronary arteries with high curvatures and bifurcations. Experience has shown that the build-up of plaque — and the resulting occlusion of blood flow — tends to occur in these complex arterial regions. The most common therapeutic strategy is the insertion of a stent to prop open the artery. However, the nature of the geometry often leads to post-stenting complications such as restenosis and thrombosis, ultimately resulting in negative outcomes. In this project, advanced research methods from fluid dynamics and optimisation and control will be used to potentially minimise these highly undesirable effects.Read moreRead less
Aligning and Chaining Carbon Nanofillers in Fibre Composites: Synergistically Improving Damage Tolerance and Diagnosis. Recent studies reveal that alternating electric or magnetic fields can rotate conductive nanofillers in polymers. This project aims to advance a new concept of aligning nano-scale reinforcements (for example, graphene nano-sheets and carbon nanofibres) along the thickness direction of composite materials. The alignment of nano-sized reinforcement will address the perennial prob ....Aligning and Chaining Carbon Nanofillers in Fibre Composites: Synergistically Improving Damage Tolerance and Diagnosis. Recent studies reveal that alternating electric or magnetic fields can rotate conductive nanofillers in polymers. This project aims to advance a new concept of aligning nano-scale reinforcements (for example, graphene nano-sheets and carbon nanofibres) along the thickness direction of composite materials. The alignment of nano-sized reinforcement will address the perennial problem of through-thickness weaknesses of fibre-reinforced composites and, at the same time, improve the electrical conductivity of composites. The synergistic improvements in the mechanical and electrical properties will improve damage tolerance and diagnosis of composites, thus expanding their applications in transport and civil construction to help reduce carbon dioxide emission.Read moreRead less
A multiplex microscope platform to define molecular events in fluid systems. This project aims to develop a novel microscopy platform that will enable the visualisation and quantification of molecular events occurring under fluid shear stress. The project will generate new knowledge in platelet biology that will allow characterisation and prediction of key molecular and morphological changes occurring across a blood thrombus under flowing conditions as found in the blood vessels. These new tools ....A multiplex microscope platform to define molecular events in fluid systems. This project aims to develop a novel microscopy platform that will enable the visualisation and quantification of molecular events occurring under fluid shear stress. The project will generate new knowledge in platelet biology that will allow characterisation and prediction of key molecular and morphological changes occurring across a blood thrombus under flowing conditions as found in the blood vessels. These new tools and the imaging platform will have applications for researchers wishing to visualise small and rapid molecular events in four dimensions (length, width, height and across time) under fluid shear stress, which is applicable across a range of industries. The project expects to deliver the next generation of intravital microscopes that can visualise and quantify events in a challenging flow environment.Read moreRead less