Enhancing Joint Replacement Outcomes Through National Data Linkage
Funder
National Health and Medical Research Council
Funding Amount
$776,063.00
Summary
This is an Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) project that involves linking Registry data with state and federal government health datasets. This will help to better understand the complications and factors affecting the rate of complication after hip, knee and shoulder joint replacement. This information will be used to improve outcomes for patients having this surgery.
Osteoarthritis is the major cause of disability in elderly Australians. It is a disease of unknown aetiology that results in deterioration of the structure and function of articular cartilage. Current treatment is palliative or involves joint replacement, which is very costly. No preventive strategies are currently available. These facts have led to 2000-2010 being labelled the Bone and Joint decade. Studies have consistently indicated a higher risk of this disease in families. This study will e ....Osteoarthritis is the major cause of disability in elderly Australians. It is a disease of unknown aetiology that results in deterioration of the structure and function of articular cartilage. Current treatment is palliative or involves joint replacement, which is very costly. No preventive strategies are currently available. These facts have led to 2000-2010 being labelled the Bone and Joint decade. Studies have consistently indicated a higher risk of this disease in families. This study will examine for novel genes for this condition in a large family study involving over 500 subjects. Identification of susceptibility or severity genes in OA is of marked importance as it is likely to lead to a better understanding of the biochemical basis of these disorders, and translate to rational therapeutic strategies and preventative strategies in at-risk individuals in the longer term.Read moreRead less
IMPROVE - Investigating Medication Re-Purposing To Reduce Risk Of OVarian Cancer And Extend Survival
Funder
National Health and Medical Research Council
Funding Amount
$430,196.00
Summary
Ovarian cancer is the 6th most common cause of cancer death in women and the proportion of women who die from their disease has not improved substantially over time. This large-scale study will use de-identified data from the Pharmaceutical Benefits Scheme, the Australian Cancer Database and the National Death Index to investigate whether medications commonly used for other conditions can help decrease the risk of ovarian cancer developing or improve survival from ovarian cancer after diagnosis.
Health And Social Consequences Of Child Abuse And Neglect: An Analysis Using South Australian Linked Data
Funder
National Health and Medical Research Council
Funding Amount
$684,447.00
Summary
Child maltreatment can result in a range of poor health, social and economic outcomes. Current surveys tell us little about the size of these impacts for young people especially for those with the worst outcomes—death, homelessness, hospitalisation, incarceration. This study will use data from hospitals, child protection and other services to explore the impacts of maltreatment on young people in SA and related costs to government, to inform policy to improve outcomes for this vulnerable group.
Defining Early Epigenetic Causes Of Cardiac Hypertrophy And Failure
Funder
National Health and Medical Research Council
Funding Amount
$620,917.00
Summary
A big heart is bad news, no matter what the cause. Sometimes this happens when the heart is under stress. At other times no cause can be found. These studies will identify the molecular switches and signals that can transform a normal heart into a big heart. Some of these are inherited, some activated by stress. Armed with knowledge of the molecular mechanisms we can identify those at risk and design new targets for novel treatment strategies.
Energy Transitions, Air Pollution And Health In Australia
Funder
National Health and Medical Research Council
Funding Amount
$2,491,229.00
Summary
Emissions from burning biomass (including fossil fuels) are major features of our environment and are the 4th leading global risk factor for premature death. As countries shift their patterns of energy use in response to global warming, new challenges are emerging. Understanding this is crucial to our ability to maintain health and stability in uncertain times. This CRE will examine the health consequences of (1) fossil fuel combustion, (2) landscape fires and (3) alternatives to fossil fuels.