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Developing A New Glaucoma Surgery Using Precision Ablation Of The Trabecular Meshwork And Inner Wall Of Schlemm’s Canal
Funder
National Health and Medical Research Council
Funding Amount
$653,606.00
Summary
Glaucoma is a major sight threatening disease in our community, affecting an estimated 60 million people worldwide. This project investigates a new laser based method for reducing intraocular pressure, the major risk factor in glaucoma. The novel approach is to create a selectable number of drainage channels for excess fluid in the eye to drain away, thereby restoring normal intraocular pressure.
Understanding The Roles Of Dendritic Domains In Neuronal Function
Funder
National Health and Medical Research Council
Funding Amount
$491,509.00
Summary
We aim to find cellular basis to cognitive function and dysfunction by understanding the input/output characterstics of individual neurons. Since neurons are fundamental computational units in the brain, we aim to understand how synaptic inputs to different dendritic regions are processed prompting the neuron to fire an output. We also aim to seek distinct roles of certain dendritic branches in gating sensory inputs onto the neuron.
Development Of An Ocular Adhesive Film With Local Drug Delivery To Prevent Infection And Inflammation In Corneal Wounds.
Funder
National Health and Medical Research Council
Funding Amount
$370,915.00
Summary
Corneal wounds and surgery are often accompanied by topical treatments to prevent infection and inflammation. The project will provide an innovative solution with a versatile, easy-to-use device that seals wounds without stitches while delivering the necessary drugs directly to the wound site. This versatile technology will prevent infection and inflammation, provide relief and encourage wound healing. It will be a world's first that will save treatment costs, reduce pain and save sight.
Improving Inner Retinal Oxygenation: Developing A New Form Of Retinal Laser Photocoagulation Therapy
Funder
National Health and Medical Research Council
Funding Amount
$408,818.00
Summary
Diabetic retinopathy is the major cause of vision loss in the working age population in our community. Current therapy involves laser destruction of much of the peripheral retina to protect the central vision. However, recent clinical and experimental evidence suggests that more moderate laser therapy could be sufficient, and that useful vision in the laser treated area can be preserved. Benefits to the patient would include reduced loss of visual field, and reduced night blindness.
Prospective Methylation Biomarker Validation Study In Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$528,281.00
Summary
Lung cancer is a major public health burden with increasing incidence every year. Despite advances, the biology of lung cancer associated with its recurrence either local or distant, with non-smoking lung cancer subtypes and asbestos-related lung cancer remains unexplored.
A Nanosecond Laser Based Surgical Treatment To Prevent Progression To Vision Loss In Early Age-related Macular Degeneration (AMD)
Funder
National Health and Medical Research Council
Funding Amount
$813,481.00
Summary
We aim to conduct a trial of a new nano-laser based treatment for Age-related Macular Degeneration (AMD) which, if successful in slowing progression of AMD, will lead to a dramatic reduction in vision loss in our community. AMD is the leading cause of irreversible vision loss in people 50 years and older in Australia. The successful outcome will postpone vision loss, benefiting many thousands of Australians, and result in substantial healthcare savings.
The Essential Nuclear Transporter Importin 13; Key Role In Brain And Testis
Funder
National Health and Medical Research Council
Funding Amount
$613,124.00
Summary
Transport into and out of the nucleus, the control centre of cells, is critical for cell function in complex organisms such as mammals. The present proposal seeks to further understanding of a novel molecule mediating nuclear transport that has a novel inhibitory form in the testis, and important roles in the lung and nervous system. The results should help basic understanding of this molecule, and relate to disease conditions such as X-linked mental retardation and childhood asthma.
Elucidating The Mechanisms Of Action Of And Resistance To Endoperoxide Antimalarials
Funder
National Health and Medical Research Council
Funding Amount
$716,755.00
Summary
Artemisinin-based antimalarials (ARTs) save hundreds of thousands of lives every year. Unfortunately resistance of P. falciparum to ART is now emerging in South East Asia and it is critical to know how and why. We will determine what is different about resistant parasites and will develop assays to monitor drug resistance in the field. We have found that the immature form of the malaria parasite is more resistant to ARTs, which helps explain resistance. We will build on this to develop new targe ....Artemisinin-based antimalarials (ARTs) save hundreds of thousands of lives every year. Unfortunately resistance of P. falciparum to ART is now emerging in South East Asia and it is critical to know how and why. We will determine what is different about resistant parasites and will develop assays to monitor drug resistance in the field. We have found that the immature form of the malaria parasite is more resistant to ARTs, which helps explain resistance. We will build on this to develop new targetted treatments.Read moreRead less
Characterising The Beta-catenin Nuclear Targeting Pathway In Cancer
Funder
National Health and Medical Research Council
Funding Amount
$485,081.00
Summary
Bowel cancer is caused by inherited gene mutations that cause build-up of beta-catenin protein in the cell nucleus. Bowel cancer is the second largest cause of cancer deaths in Australia. We aim to study the mechanisms controlling beta-catenin accumulation in the nucleus. We will characterise new signalling pathways that control movement and activity of beta-catenin in the nucleus. This will yield insights into the role of beta-catenin in cancer and possible targets for therapy.
Physiological Mechanisms Of Experimental Preeclampsia.
Funder
National Health and Medical Research Council
Funding Amount
$471,862.00
Summary
Defining the sequence of abnormalities of immune system regulation and vascular reactivity would greatly enhance our understanding of the underlying mechanisms of preeclampsia (hypertension in pregnancy) and lead to opportunities for definitive treatment for the mother and baby other than by urgent delivery of the pregnancy. Results from this study may lead to tests in early pregnancy of the hypoxic environment such as cytokine imbalance.