Seizures And Carbon Dioxide – A Study Of Respiratory Acidosis As A Cause For Seizure Termination And Trial Of Carbogen As An Anti-epileptic
Funder
National Health and Medical Research Council
Funding Amount
$317,582.00
Summary
Although much is known about epilepsy, the reason a seizure stops is not clear. A rise in the acidity of the blood, mainly due to a rise in carbon dioxide from breathing less deeply, may well contribute. Currently the standard treatments given in hospital to stop seizures are sedatives. Although effective, this sedation can need Intensive Care treatment. We aim to develop a safe, rapid, non-sedating way to treat seizures using a small amount of carbon dioxide in oxygen.
Development Of Selective Blockers Of Acid Sensing Ion Channel 1a For The Treatment Of Stroke
Funder
National Health and Medical Research Council
Funding Amount
$702,443.00
Summary
Stroke is the second leading cause of death worldwide. In addition, stroke causes an extremely high incidence of disability in surviving victims due to the brain damage suffered during stroke. Unfortunately, no effective neuroprotective therapy is currently available for stroke patients. In this project we plan to develop novel neuroprotective agents that are effective even when used many hours after stroke, thus providing a wide therapeutic time window for treatment of stroke patients.