A Study Of Artemisinin Combination Therapy Given At Delivery To Prevent Postpartum Malaria And To Young Infants To Treat Uncomplicated Malaria
Funder
National Health and Medical Research Council
Funding Amount
$788,850.00
Summary
The proposed studies will investigate the preventive value of a course of combination antimalarial treatment at delivery in pregnant women in malarial areas. The transfer of this treatment into breast milk and to the suckling infant will be investigated since this may protect the infant against malaria but also cause drug-related side-effects. These data will be used, with a study of combination treatment in infants with malaria, to optimise dose regimens in this vulnerable group.
ELF5 Integrates Prolactin And Progestin Control Of Mammary Gland Development Via Regulation Of Progenitor Cells.
Funder
National Health and Medical Research Council
Funding Amount
$720,515.00
Summary
Elf5 may act as a master-regulator of mammary cell growth during pregnancy. We will demonstrate that Elf5 can replace the requirement for prolactin and progesterone to trigger mammary development and we will determine the stem or progenitor cells Elf5 acts on. Finally we will apply this knowledge to breast cancer cell lines to discover what role Elf5 plays in breast cancer. These experiments have the potential to establish Elf5 as a new therapeutic target for the treatment of breast cancer.
Strategies To Increase Breastfeeding Duration In Australia
Funder
National Health and Medical Research Council
Funding Amount
$285,870.00
Summary
I am a general practitioner and lactation consultant with expertise in breastfeeding research and practice. I am an international expert in nipple and breast pain in breastfeeding women, and have published widely on other clinical topics, including medications for breastfeeding women; also breastfeeding rates and factors associated with lower rates, such as maternal smoking, obesity and low-income. This fellowship allows me to look at ways to improve breastfeeding rates in Australia and to impro ....I am a general practitioner and lactation consultant with expertise in breastfeeding research and practice. I am an international expert in nipple and breast pain in breastfeeding women, and have published widely on other clinical topics, including medications for breastfeeding women; also breastfeeding rates and factors associated with lower rates, such as maternal smoking, obesity and low-income. This fellowship allows me to look at ways to improve breastfeeding rates in Australia and to improve the experience for women and their families.Read moreRead less
Roles Of PTHrP And Calcium In Mammary Function In Perinatal Growth Restriction
Funder
National Health and Medical Research Council
Funding Amount
$376,320.00
Summary
Babies that are born small have significant problems around the time of birth and may have limited catch-up growth. A recently discovered protein known as PTHrP influences the nutrition of the growing newborn through breast milk. Because of its potential importance to small babies we intend to study this protein during and after pregnancy in rats and their pups. New treatments may emerge from the knowledge gained from these studies that may improve the growth and health of infants.
Best Fed: Implementing Evidence Based Clinical Practice Guidelines To Improve Breast Milk Use And The Feeding Management Of Infants Born
Funder
National Health and Medical Research Council
Funding Amount
$177,197.00
Summary
Breast milk is the best food for babies born prematurely. There are challenges for women in providing breast milk and challenges for clinicians in managing the feeds of preterm babies, including when to start feeds and how quickly to progress. Sometimes research evidence doesn’t translate into practice and in this project I will support clinicians to implement the best evidence so that more preterm babies are receiving breast milk on discharge home.