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FRDC has obtained Board approval FRDC Board Meeting # 194, 24 November 2022) to become a member of CRC SAAFE and investment up to $1.0 million. This project is needed to manage the FRDC investment that will be comprised of investments seafood related projects. Conducting projects within CRC SAAFE will provide linkages to additional resources, expertise and knowledge sharing that will improve project outputs and foster national collaboration in addition to that currently provided by the FRDC. Th ....FRDC has obtained Board approval FRDC Board Meeting # 194, 24 November 2022) to become a member of CRC SAAFE and investment up to $1.0 million. This project is needed to manage the FRDC investment that will be comprised of investments seafood related projects. Conducting projects within CRC SAAFE will provide linkages to additional resources, expertise and knowledge sharing that will improve project outputs and foster national collaboration in addition to that currently provided by the FRDC. This will include the research and industry participants that are partners of CRC SAAFE. Objectives: 1. Best practice AMR mitigation and management in the seafood industry and the aquatic environment. 2. Improved biosecurity and animal welfare through development of vaccines to minimise use of antibiotics. Read moreRead less
Optimizing Outpatient Parenteral Antibiotic Therapy To Support Hospital-in-the-home Program Across The Unique Environmental Conditions Of Australia
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
This project aims to solve problems associated with stability and dosing of antibiotic infusions given to patients in their homes, to support decision making by doctors and regulators. Currently, there is a lack of adequate data that complies with contemporary requirements. We will study infusion preparation both in laboratory settings and in ‘real-life’ conditions while being used by patients. We will enhance the stability of antibiotic preparations and optimize doses for effective treatment.
Broadening Choice and Increasing Diversity in Public Schools. Currently, most families are limited to the public school in their catchment area, meaning the area in which they can afford to live. This leads to socio-economically and ethnically homogenous schools and entrenches disadvantage, as well as denying students the crucial life lessons that flow from being part of a diverse student body. This project aims to investigate a model for allocating public school places that integrates catchment ....Broadening Choice and Increasing Diversity in Public Schools. Currently, most families are limited to the public school in their catchment area, meaning the area in which they can afford to live. This leads to socio-economically and ethnically homogenous schools and entrenches disadvantage, as well as denying students the crucial life lessons that flow from being part of a diverse student body. This project aims to investigate a model for allocating public school places that integrates catchment areas. The expected outcome would be a system that gives families a wider choice, enabling them to enrol in out-of-area schools, while ensuring that allocations remain fair, equitable and balanced, and also delivering benefits such as achieving a desired level of diversity in student populations within schoolsRead moreRead less
A Trivalent Vaccine For Sustainable Yellowtail Kingfish Growout
Funder
Fisheries Research and Development Corporation
Funding Amount
$809,040.00
Summary
Optimised vaccines deliver improved animal health and avoid use of antimicrobials in the production of fish (Sommerset et al., Expert Review Vaccines 2005, 4, 89-101.). Australian YTK Photobacteriosis outbreaks have been reported in association with Photobacterium damselae subsp damselae (Pdd), Photobacterium damselae subspecies piscicida(Pdp) and various Vibrio harveyi(Vh) isolates (Matt Landos, Nicky Buller, unpublished). To support stable production of high quality finfish highly efficacious ....Optimised vaccines deliver improved animal health and avoid use of antimicrobials in the production of fish (Sommerset et al., Expert Review Vaccines 2005, 4, 89-101.). Australian YTK Photobacteriosis outbreaks have been reported in association with Photobacterium damselae subsp damselae (Pdd), Photobacterium damselae subspecies piscicida(Pdp) and various Vibrio harveyi(Vh) isolates (Matt Landos, Nicky Buller, unpublished). To support stable production of high quality finfish highly efficacious controls of microbial diseases are critical. Successful examples are currently employed in salmon (Yersinia ruckeri, Vibrio anguillarum) and barramundi (Streptococcus iniae) whereby disease outbreaks drove the need for vaccine development. These conditions are now both well controlled in vaccinated populations and have dramatically reduced reliance on administration of antibiotics. Currently, crude autogenous vaccines are in use with YTK for control of only Pdd in South Australia and Western Australia with some reported success. Recently Pdp has emerged as a significant pathogen in South Australian outbreaks. Reliable vaccination against Pdp has proven difficult in international experience using traditional autogenous and generic killed vaccine methods, hence increasingly research is exploring DNA vaccination methods to improve protection against this pathogen (Kato et al., Vaccine 2015, 33 (8), 1040-1045). It is also probable that antigenic diversity had been underestimated, given high diversity that recent sequencing technology has revealed in our preliminary research . Preparedness for the emergence of highly pathogenic Pdp strains is prudent to allow rapid controls to be developed, without incurring business-ending losses within the growing aquaculture sector, or having high levels of reliance on oral antibiotics. Genetic sequence data on isolates generated through this project can be used for epidemiological modelling, new rapid diagnostic typing tools and immediate response if disease emergence occurs in other finfish industries. Pdp is acknowledged as a serious pathogen internationally in species including yellowtail, cobia, flounder, seabream, pompano and sea bass. (Andreoni et al.J Immunol Res. 2014).
Objectives: 1. Generate comprehensive genome database of Australian isolates of Pdd, Pdp and Vh associated with Photobacteriosis outbreaks in YTK 2. Generate and supply diagnostic laboratory reagents and methods for typing Photobacterium and Vibrio isolates associated with YTK outbreaks. 3. Deliver optimised monovalent and multivalent (Pdd, Pdp, Vh) killed vaccines, with production outline, appropriate adjuvant type, dose, safety and efficacy profile in YTK, ready for manufacture. Read moreRead less
Testing strategy-proofness in matching markets: an experimental study. This project seeks to test and improve matching algorithms by investigating the effect of advice on strategy-proofness. Matching algorithms are used to solve allocation problems in designed markets (eg school or house allocation problems). Many of the algorithms employed are strategy-proof: participants never gain from strategising, that is, from lying about their preferences. Strategy-proofness had been seemingly validated b ....Testing strategy-proofness in matching markets: an experimental study. This project seeks to test and improve matching algorithms by investigating the effect of advice on strategy-proofness. Matching algorithms are used to solve allocation problems in designed markets (eg school or house allocation problems). Many of the algorithms employed are strategy-proof: participants never gain from strategising, that is, from lying about their preferences. Strategy-proofness had been seemingly validated by experimental research, but new evidence suggests that participants could be prone to follow wrong advice and therefore lie. In order to improve the performance of designed markets, the project proposes to further test strategy-proofness by investigating how advice can affect truth-telling in strategy-proof algorithms and whether learning can counteract or complement the effect of advice.Read moreRead less
Advancing Physiotherapy Management Of Chronic Pain By Improving Implementation Of Evidence-based Practice
Funder
National Health and Medical Research Council
Funding Amount
$115,883.00
Summary
Chronic musculoskeletal pain is major and concerning public health burden and physiotherapists provide a vital and influential role in managing this problem. High level research has demonstrated effective approaches to managing chronic pain yet there appears to be barriers to implementing such strategies clinically. This project aims to explore these barriers with physiotherapists, devise an intervention to overcome them, and test the feasibility and acceptability of the intervention.
Structural safety guidelines for accidental hydrogen explosion hazards . This project aims to develop structural safety guidelines to mitigate hydrogen explosion hazards which can be identified as a major safety concern due to the higher demand worldwide for sustainable energy sources with no carbon emission. The world’s growing demand for hydrogen and Australia’s National Hydrogen Strategy to develop the industry will make Australia a core player in hydrogen production creating a massive econom ....Structural safety guidelines for accidental hydrogen explosion hazards . This project aims to develop structural safety guidelines to mitigate hydrogen explosion hazards which can be identified as a major safety concern due to the higher demand worldwide for sustainable energy sources with no carbon emission. The world’s growing demand for hydrogen and Australia’s National Hydrogen Strategy to develop the industry will make Australia a core player in hydrogen production creating a massive economic opportunity. However, the high flammability and low ignition energy of hydrogen makes it vulnerable to accidental explosions. Hence, this project will address the lack of safety protocols in Australian Standards related to the handling of hydrogen by producing essential design recommendations.Read moreRead less
Evaluation Of Cobia And Giant Groper Production And Health In Multiple Growout Systems, As An Alternative Species To Farm In WSSV Affected Areas Of South East Queensland
Funder
Fisheries Research and Development Corporation
Funding Amount
$150,000.00
Summary
The production and health performance of emerging aquaculture species, cobia and giant grouper, in former prawn farm pond and tank infrastructure is not well documented. The development of these alternative species offers flexibility and new production opportunities to WSSV affected farms in SE Queensland, and elsewhere in Australia to expand aquaculture production more generally.
Fish health problems are a common cause of aquaculture business failure. In prior pilot trials, significant ....The production and health performance of emerging aquaculture species, cobia and giant grouper, in former prawn farm pond and tank infrastructure is not well documented. The development of these alternative species offers flexibility and new production opportunities to WSSV affected farms in SE Queensland, and elsewhere in Australia to expand aquaculture production more generally.
Fish health problems are a common cause of aquaculture business failure. In prior pilot trials, significant health challenges were encountered that require thorough veterinary investigation and intervention. The information learnt from investigations can then form components of a health management plan for the culture of these two species in SE Queensland, in various systems. The description of health challenges through veterinary outbreak investigation allows the development and costing of interventions to prevent or treat the issue. Over the 12 month time frame of this project, surveillance strategies can be developed for early detection of disease. Such health management strategies facilitate early response actions that can minimise losses associated with infectious disease.
One metric which influences the viability of aquaculture systems is the density at which a species can be farmed. This is particularly the case in RAS, where the infrastructure capital costs are high. This project will document the impacts of stocking density on health and production in RAS, cages and ponds.
Another element that strongly influences viability of aquaculture enterprises is the growth rates of stock that are able to be achieved. Generating data from systems farmed at commercial densities can assist in determining the suitability of various sites for expansion of farming these species in Australia.
Objectives: 1. Generate data on the production and health performance of Giant Grouper and Cobia in RAS, cages in a saline lake and in outdoor pond growout systems. 2. Field test production outcomes from an experimental recombinant autogenous vaccine for prevention of nodavirus in the Giant Grouper. 3. Assess market potential for various formats of cobia and grouper Read moreRead less
Extracting energy from air: mechanism of a bacterial hydrogenase. The atmosphere has recently been shown to be a key source of energy for diverse soil bacteria. Bacteria use complex enzymes, namely Huc-type hydrogenases, to harvest atmospheric hydrogen directly from air to support growth and survival. However, little is known about how Huc functions within and outside cells. By synergising expertise in microbiology, biochemistry, and chemistry, we will resolve the mechanism, assembly, and integr ....Extracting energy from air: mechanism of a bacterial hydrogenase. The atmosphere has recently been shown to be a key source of energy for diverse soil bacteria. Bacteria use complex enzymes, namely Huc-type hydrogenases, to harvest atmospheric hydrogen directly from air to support growth and survival. However, little is known about how Huc functions within and outside cells. By synergising expertise in microbiology, biochemistry, and chemistry, we will resolve the mechanism, assembly, and integration of Huc, including the basis of its remarkably high affinity and oxygen insensitivity compared to previously studied hydrogenases. This project will enable biotechnological applications, as the first study of an enzyme that extracts energy from air, and has broad ecological and biogeochemical implications.Read moreRead less