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I am a virologist working on hepatitis C virus with projects to investigate antiviral agents, vaccine technology, aspects of HCV immunity and treatment by immunotherapy.
New Interventions To End Neglected Tropical Diseases In Asia
Funder
National Health and Medical Research Council
Funding Amount
$926,980.00
Summary
My research goal is to eliminate parasitic worm infestations globally. These parasites cause substantial illness and affect the world's poorest people. Programs that drug treat infected individuals operate but these are neither effective nor sustainable. Our research has shown that additional measures, such as vaccination and health education, are needed and we aim to develop and field test a combination of interventions that will lead to their sustainable control and eventual elimination.
Immunobilogy Of Human Herpesviruses: From Bench To Bedside
Funder
National Health and Medical Research Council
Funding Amount
$926,980.00
Summary
This Fellowship application is aiming to translate our newly emerging knowledge on immune regulation of human herpesviruses and associated diseases from bench to bedside. We are aiming develop new platform technologies which will allow us to test novel immunotherapeutic strategies to treat herpesvirus-associated diseases.
A Proteome-wide Approach To Anti-viral Immunity And Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$622,655.00
Summary
We know that many parts of viruses are displayed to the immune system, but at present the exact fragments are difficult to predict, we do not know all the genes in our bodies that control this process and we also need better methods to study the way some viruses (e.g. the cold sore virus) avoid detection. This project will study these problems with the overall goal of improving vaccine design, understanding immune deficiency and how viruses fight back against our immune system.
My research is aiming to study how the immune system controls viral infections in transplant patients and use this information to bolster their immunity in a test tube, providing protection against a virus the patient is unable to fight after their transplant. We are also trying to develop new strategies to use patient's own blood cells which will be grown in the laboratory and returned to the patient, resulting in a full recovery.
Enabling Technologies For Design And Delivery Of Novel Vaccines Against Infectious Diseases And Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$925,346.00
Summary
This grant will support research necessary to develop the next generation of vaccines. These will combat diseases caused by bacteria and viruses and can also be used to fight cancer. The broad range of application is made possible through the incorporation of simple molecular features that activate the immune system. The intellectual property that has been developed is protected by a patent portfolio some patents of which are already licenced to the pharmaceutical industry.
In the Northern Territory, about twenty per cent of Indigenous children have perforated ear drums. Menzies research already shows medical treatments in high-risk Indigenous settings to be less effective than in non-Indigenous settings. I will lead an interdisciplinary team to develop, pilot, design and evaluate the effect of a comprehensive intervention program including best use of vaccines, reducing risk factors and maximising hygiene to prevent early age of first infection.
Preventing Infectious Disease In Vulnerable Populations: Smarter Surveillance, Enhanced Epidemiology And Targeted Trials
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
Vulnerable populations, including people who inject drugs and female sex workers, are susceptible to infectious diseases such as HIV and hepatitis C. Preventing the transmission of these infections presents major challenges. The proposed research will 1) develop innovative approaches to identifying and understanding infectious disease in vulnerable populations; 2) improve our responses by designing and testing new approaches to prevention; and 3) reduce associated morbidity and mortality.
This an integrated program of basic research on antigen discovery and immune mechanisms, and preclinical research on novel vaccine platforms, formulations or delivery systems for the rational design and clinical testing of a next generation vaccine against malaria. This interdisciplinary research fosters strong national and international links and offers the potential for significant economic benefit to Australia.
We will investigate malaria, a parasitic disease that kills over 2 million people a year. We will explore how the parasite identifies, invades and remodels the host cells in which it lives, scavenging nutrients and hiding from the immune system. We will characterize the proteins involved in these critical events, as they are potential targets for drugs and vaccines. We will study how parasites cause disease and how the host responds to infection.