Extracting energy from air: mechanism of a bacterial hydrogenase. The atmosphere has recently been shown to be a key source of energy for diverse soil bacteria. Bacteria use complex enzymes, namely Huc-type hydrogenases, to harvest atmospheric hydrogen directly from air to support growth and survival. However, little is known about how Huc functions within and outside cells. By synergising expertise in microbiology, biochemistry, and chemistry, we will resolve the mechanism, assembly, and integr ....Extracting energy from air: mechanism of a bacterial hydrogenase. The atmosphere has recently been shown to be a key source of energy for diverse soil bacteria. Bacteria use complex enzymes, namely Huc-type hydrogenases, to harvest atmospheric hydrogen directly from air to support growth and survival. However, little is known about how Huc functions within and outside cells. By synergising expertise in microbiology, biochemistry, and chemistry, we will resolve the mechanism, assembly, and integration of Huc, including the basis of its remarkably high affinity and oxygen insensitivity compared to previously studied hydrogenases. This project will enable biotechnological applications, as the first study of an enzyme that extracts energy from air, and has broad ecological and biogeochemical implications.Read moreRead less
An International Comparison Of Systems Of Care, Risk Stratification And Outcomes In TIA And Minor Stroke
Funder
National Health and Medical Research Council
Funding Amount
$1,189,790.00
Summary
Transient ischaemic attacks (TIAs: self-limited brief episodes of stroke symptoms) are high-risk events with an approximately 15% risk of stroke within 90-days. Current practice calls for specialist treatment within 1-7 days. But this recommendation (based on 20 year old overseas evidence) may not apply in contemporary Australia. We will conduct a study of patients with TIA that will document their interactions with Australian health systems and inform contemporary Australian practice.
Living on air: how do bacteria scavenge atmospheric trace gases? This project aims to determine the molecular and cellular basis of atmospheric trace gas oxidation by bacteria. Bacteria have a remarkable ability to adapt to resource limitation and environmental change by entering dormant states. Our research has shown they survive in this state by using atmospheric hydrogen and carbon monoxide as energy sources. This interdisciplinary project will determine how bacteria achieve this by elucidati ....Living on air: how do bacteria scavenge atmospheric trace gases? This project aims to determine the molecular and cellular basis of atmospheric trace gas oxidation by bacteria. Bacteria have a remarkable ability to adapt to resource limitation and environmental change by entering dormant states. Our research has shown they survive in this state by using atmospheric hydrogen and carbon monoxide as energy sources. This interdisciplinary project will determine how bacteria achieve this by elucidating the regulation, mechanism, and integration of the three uncharacterised enzymes that mediate this process. Outcomes and benefits include understanding of the processes that facilitate bacterial persistence, regulate atmospheric composition, and in turn support resilience of natural ecosystems.Read moreRead less
Decentralised assets trading, centralised clearing and systemic risk. This project aims to study the effect of regulating over-the-counter (OTC) financial markets on economic performance. The lack of transparency of OTC financial markets may have exacerbated the severity of the 2007-09 financial crisis. In response, regulators around the world decided to mandate centralised clearing of derivatives traded OTC, believing this would reduce system-wide risk. This project will study the regulatory ch ....Decentralised assets trading, centralised clearing and systemic risk. This project aims to study the effect of regulating over-the-counter (OTC) financial markets on economic performance. The lack of transparency of OTC financial markets may have exacerbated the severity of the 2007-09 financial crisis. In response, regulators around the world decided to mandate centralised clearing of derivatives traded OTC, believing this would reduce system-wide risk. This project will study the regulatory change’s effects on market participation, volumes of trade and prices, and the behavioural effect of shifting risk from market participants to clearinghouses. It expects to suggest remedial policies clearinghouses could implement to control market participants’ risk appetite. These can help enhance future productivity and reduce unemployment in Australia.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100468
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Scalable high-performance electrolytic hydrogen generator. The project aims to demonstrate energy-efficient generation of compressed hydrogen by water electrolysis in a high pressure electrolyser test-rig produced by Melbourne company Energys Australia P/L, using high-performance membrane-electrode assemblies. Innovative electrode architectures, membranes, and method for their high through-put lamination will be developed. New knowledge in catalysis, device fabrication and materials science is e ....Scalable high-performance electrolytic hydrogen generator. The project aims to demonstrate energy-efficient generation of compressed hydrogen by water electrolysis in a high pressure electrolyser test-rig produced by Melbourne company Energys Australia P/L, using high-performance membrane-electrode assemblies. Innovative electrode architectures, membranes, and method for their high through-put lamination will be developed. New knowledge in catalysis, device fabrication and materials science is expected to be generated. The major project outcome is sustainable method for generation of compressed hydrogen at significantly reduced cost as compared to the existing technologies. Benefits include industry-ready processes for electrolyser and hydrogen production that support Australian energy industries.Read moreRead less
Bulk Mg based hydrogen storage alloys with faster activation. Bulk Mg based hydrogen storage alloys with faster activation. This project aims to improve the performance and efficiency of manufacture of magnesium-based hydrogen storage alloys, making them more cost competitive and widely useable. A hydrogen economy will reduce greenhouse gas emissions and improve air quality in urban areas. The expected outcomes are an understanding of the mechanisms governing the activation process, a necessary ....Bulk Mg based hydrogen storage alloys with faster activation. Bulk Mg based hydrogen storage alloys with faster activation. This project aims to improve the performance and efficiency of manufacture of magnesium-based hydrogen storage alloys, making them more cost competitive and widely useable. A hydrogen economy will reduce greenhouse gas emissions and improve air quality in urban areas. The expected outcomes are an understanding of the mechanisms governing the activation process, a necessary step in manufacture, and techniques to exploit these mechanisms to minimise the activation time. This is expected to develop competitive, bulk magnesium-based hydrogen storage alloys for effective and safe hydrogen storage systems.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100084
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
Australia’s fuel cells and electrolysers prototyping and testing facility. This project aims to address a major gap in Australian infrastructure for researching and developing technologies for Power to X, including hydrogen production and use. The aspiration is to establish an integrated fuel cell and electrolyser prototyping and testing facility to support Australia’s excellent fundamental research in advanced energy materials, electrocatalysis, and engineering design. The aim is to equip the r ....Australia’s fuel cells and electrolysers prototyping and testing facility. This project aims to address a major gap in Australian infrastructure for researching and developing technologies for Power to X, including hydrogen production and use. The aspiration is to establish an integrated fuel cell and electrolyser prototyping and testing facility to support Australia’s excellent fundamental research in advanced energy materials, electrocatalysis, and engineering design. The aim is to equip the research community with the capability to fabricate electrolyser and fuel cell prototypes at relevant scales to accelerate translational research in these areas. Doing so will also enable the technical and expertise platform needed to support industry's transition toward Australia’s 2050 net zero objective.Read moreRead less
System identification of microstructure in the brain using magnetic resonance. Magnetic Resonance Imaging technologies will be exploited to probe the microstructure of the brain, using powerful Bayesian optimisation techniques and innovative uses of magnetic resonance. The project will in particular develop non-invasive imaging methods to quantify iron content in the brain, important for research on dementia and Alzheimer's disease.
The recirculation of myeloid dendritic cells. This project aims to understand dendritic cell recirculation. It will use virological tools to track dendritic cell migration, and identify key decision points. Expected outcomes include enhanced capacity in basic research and greater interdisciplinary collaboration between virology and immunology research groups. Significant benefits will include a new understanding of how G protein coupled receptor signalling and other tissue cues guide dendritic c ....The recirculation of myeloid dendritic cells. This project aims to understand dendritic cell recirculation. It will use virological tools to track dendritic cell migration, and identify key decision points. Expected outcomes include enhanced capacity in basic research and greater interdisciplinary collaboration between virology and immunology research groups. Significant benefits will include a new understanding of how G protein coupled receptor signalling and other tissue cues guide dendritic cell recirculation, and what consequences the recirculation has for immune cell function. This understanding will significantly advance our basic understanding of the immune system.Read moreRead less
Towards highly-efficient hydrogen gas turbines. The increasing interest in green hydrogen has led to a need for research and development in combustion systems that can accommodate hydrogen. One promising technology is low-emission gas turbines, which is a key player in the electricity market. However, hydrogen gas turbines are susceptible to a phenomenon called thermoacoustic instability, causing loud noise and can damage equipment. This project represents the first comprehensive study of the ef ....Towards highly-efficient hydrogen gas turbines. The increasing interest in green hydrogen has led to a need for research and development in combustion systems that can accommodate hydrogen. One promising technology is low-emission gas turbines, which is a key player in the electricity market. However, hydrogen gas turbines are susceptible to a phenomenon called thermoacoustic instability, causing loud noise and can damage equipment. This project represents the first comprehensive study of the effects of hydrogen fuel on thermoacoustic instability under conditions relevant to gas turbines. By examining low-order models, commonly used for designing gas turbines, this project can significantly advance the field and facilitate the adoption of green hydrogen as a fuel source.Read moreRead less