Hydrogen generation by subsurface iron mineral transformations. Aim
The aim of this project is to elucidate key factors responsible for natural hydrogen generation in Australian subsurface environments.
Significance
Large amounts of this valuable resource are produced naturally with estimates of production rates of this “gold” hydrogen at least 100 times the annual demand for this critical resource.
Expected Outcomes
Based on improved understanding of the source of natural hydrogen, predictive ....Hydrogen generation by subsurface iron mineral transformations. Aim
The aim of this project is to elucidate key factors responsible for natural hydrogen generation in Australian subsurface environments.
Significance
Large amounts of this valuable resource are produced naturally with estimates of production rates of this “gold” hydrogen at least 100 times the annual demand for this critical resource.
Expected Outcomes
Based on improved understanding of the source of natural hydrogen, predictive tools will be developed that will assist in assessing the viability in Australia of hydrogen exploration and engineered retrieval.
Benefits
Ready access to naturally produced hydrogen could enable Australia to replace hydrogen that is currently generated via the use of unabated hydrocarbons.Read moreRead less
Lifting the Veil on Cold Planets in the Inner Galaxy. The project aims to explore a unique aspect of exoplanet detection: searches for cold planets of Earth mass and larger in the densest stellar fields of the inner Milky Way. Infrared cameras will be used to detect small planets in this extreme galactic environment. The proposed project will open a new era of infrared microlensing observations from the ground and supply critical data in preparation for the next generation of microlensing from s ....Lifting the Veil on Cold Planets in the Inner Galaxy. The project aims to explore a unique aspect of exoplanet detection: searches for cold planets of Earth mass and larger in the densest stellar fields of the inner Milky Way. Infrared cameras will be used to detect small planets in this extreme galactic environment. The proposed project will open a new era of infrared microlensing observations from the ground and supply critical data in preparation for the next generation of microlensing from space. This work directly links to the Nancy Grace Roman Telescope (2026 launch) Galactic Exoplanet Survey. Expected outcomes are a greatly improved understanding of planet formation down to terrestrial-mass planets, and improved techniques for cold planet detection with gravitational microlensing. Read moreRead less
Improving Stroke Outcomes: Attenuating Progression And Recurrence
Funder
National Health and Medical Research Council
Funding Amount
$9,331,996.00
Summary
Stroke is the second most common cause of death and major cause disability. There are few proven interventions, so we need to introduce new ones. We developed a bench to bedside program to introduce new stroke therapies and its early secondary prevention. Our general goal is to provide evidence for their effectiveness and safety. We will use animal stroke models, markers in the blood to help diagnose and predict stroke outcome and imaging to help select patients for several clinical trials.
Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The pr ....Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The project will provide fundamental advances in our knowledge of the nutrient transport during pregnancy that is required to produce a healthy baby.Read moreRead less
The Occurrence of Cold Planets in the Galaxy. The project aims to explore a unique niche in exoplanet detection: searches for cold planets down to Earth mass, including ice giants and rogue free-floating planets. Infrared cameras and adaptive optics on large telescopes will be used to make accurate measurements of cold planets in diverse galactic environments. These are significant because they are completely different from most known exoplanets, being far from their host stars and unique probes ....The Occurrence of Cold Planets in the Galaxy. The project aims to explore a unique niche in exoplanet detection: searches for cold planets down to Earth mass, including ice giants and rogue free-floating planets. Infrared cameras and adaptive optics on large telescopes will be used to make accurate measurements of cold planets in diverse galactic environments. These are significant because they are completely different from most known exoplanets, being far from their host stars and unique probes of planet formation theory. Expected outcomes are a greatly improved understanding of planet formation, and improved techniques for cold planet detection with gravitational microlensing. The project will strongly benefit the next generation space-based programs planned for the next decade.Read moreRead less
A novel regulator of growth signalling in Drosophila. This project aims to increase understanding of how growth is regulated by growth factor hormones. In animals, growth is controlled by signalling pathways that are activated by secreted peptide hormones. A new regulator of growth in the fruitfly Drosophila, the membrane attack complex/perforin-like (MACPF) protein Torso-like, has been identified. The project aims to unravel how Torso-like functions to regulate growth, thus throwing light on th ....A novel regulator of growth signalling in Drosophila. This project aims to increase understanding of how growth is regulated by growth factor hormones. In animals, growth is controlled by signalling pathways that are activated by secreted peptide hormones. A new regulator of growth in the fruitfly Drosophila, the membrane attack complex/perforin-like (MACPF) protein Torso-like, has been identified. The project aims to unravel how Torso-like functions to regulate growth, thus throwing light on the role this protein family may play in all animals. The findings are expected to provide key insights into the modification of growth factor activity, which is often dysregulated in human cancers and growth disorders, and may enable the design of new strategies for interfering with insect development for pest control.Read moreRead less
Microfluidic models of the CNS: Understanding cells, circuits & synapses. Aims: We aim to develop new cell culture platforms to form defined networks of brain cells. These platforms will be used to determine the critical mechanisms underpinning central nervous system function.
Significance: The devices developed will enable an unprecedented capacity to monitor changes throughout a network, with analysis at the level of the synapse, cell and circuit.
Expected outcomes: We will advance knowledge ....Microfluidic models of the CNS: Understanding cells, circuits & synapses. Aims: We aim to develop new cell culture platforms to form defined networks of brain cells. These platforms will be used to determine the critical mechanisms underpinning central nervous system function.
Significance: The devices developed will enable an unprecedented capacity to monitor changes throughout a network, with analysis at the level of the synapse, cell and circuit.
Expected outcomes: We will advance knowledge regarding the function of the CNS and deliver complex human cellular systems, that have both discovery and commercial applications.
Benefit: These platforms will have subsequent application revealing the mechanisms underlying numerous neurological diseases, with capacity to upscale for rapid drug screening.
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Building futures for young Australians at risk: a coordinated measurement framework and data archive. This project will build a national data base of evidence about and for programs that address the needs of the 16 per cent of young Australians currently at risk of school non-completion. It will generate important knowledge for program improvement and sustainability and coordination of evidence across diverse and fragmented programs.
Warratyi: Cultural Innovation in the Indigenous Settlement of Australia. This project aims to determine the role of cultural innovation in the Indigenous settlement of Australia's arid zone 50,000 years ago. Using innovative methods, it will produce new data on key technologies, symbolic behaviours and human interactions with animals and environment to identify the cultural innovations needed to overcome the challenges of Australia's deserts. Expected outcomes include new understandings of the s ....Warratyi: Cultural Innovation in the Indigenous Settlement of Australia. This project aims to determine the role of cultural innovation in the Indigenous settlement of Australia's arid zone 50,000 years ago. Using innovative methods, it will produce new data on key technologies, symbolic behaviours and human interactions with animals and environment to identify the cultural innovations needed to overcome the challenges of Australia's deserts. Expected outcomes include new understandings of the settlement of the arid zone to inform global debates relating to the dispersal, settlement and lifestyles of early humans in marginal environments. Expected benefits include new information for cultural tourism and education and to support South Australia’s World Heritage nomination for the Flinders Ranges.Read moreRead less
ARC Research Network in Enterprise Information Infrastructure. EII targets consolidated research towards the comprehensive development & establishment of advanced information infrastructures. Its prime purpose is to provide a forum for intellectual exchange by diverse yet complementary research groups, to address the fundamental research problems faced by scientific & business communities when dealing with deployment of information technology to globally distributed, and data intensive environme ....ARC Research Network in Enterprise Information Infrastructure. EII targets consolidated research towards the comprehensive development & establishment of advanced information infrastructures. Its prime purpose is to provide a forum for intellectual exchange by diverse yet complementary research groups, to address the fundamental research problems faced by scientific & business communities when dealing with deployment of information technology to globally distributed, and data intensive environments. EII will address 3 tightly coupled research themes: Ability to interoperate across existing heterogenous platforms & applications; Efficient processing of very large data sets; Technology adoption & impact. Generic results will be applicable to e-science and large business information systems installations.Read moreRead less