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Research Topic : Knowledge based systems
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  • Funded Activity

    An International Comparison Of Systems Of Care, Risk Stratification And Outcomes In TIA And Minor Stroke

    Funder
    National Health and Medical Research Council
    Funding Amount
    $1,189,790.00
    Summary
    Transient ischaemic attacks (TIAs: self-limited brief episodes of stroke symptoms) are high-risk events with an approximately 15% risk of stroke within 90-days. Current practice calls for specialist treatment within 1-7 days. But this recommendation (based on 20 year old overseas evidence) may not apply in contemporary Australia. We will conduct a study of patients with TIA that will document their interactions with Australian health systems and inform contemporary Australian practice.
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    Funded Activity

    SEA-URCHIN: South East Asia - Using Research For Change In Hospital-acquired Infection In Neonates

    Funder
    National Health and Medical Research Council
    Funding Amount
    $2,303,773.00
    Summary
    Each year, more than one million babies die from infection before they reach one month of age. Proven and inexpensive practices to prevent and treat infection exist but they are not always followed (eg hand washing). This research will evaluate the impact of tailored implementation strategies on rates of infection and death in the neonatal units of nine hospitals in four counties in South East Asia. Staff from these units will work with Australian partners to devise, implement and evaluate diffe .... Each year, more than one million babies die from infection before they reach one month of age. Proven and inexpensive practices to prevent and treat infection exist but they are not always followed (eg hand washing). This research will evaluate the impact of tailored implementation strategies on rates of infection and death in the neonatal units of nine hospitals in four counties in South East Asia. Staff from these units will work with Australian partners to devise, implement and evaluate different strategies.
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    Funded Activity

    Pathways To Prevention: The Effectiveness Of Universal And Selective Prevention In Altering Developmental Pathways To Alcohol And Cannabis Related Harms In Young Adults

    Funder
    National Health and Medical Research Council
    Funding Amount
    $465,967.00
    Summary
    This project will assess the potential long-term benefits for young Australians of two school-based drug prevention programs (Climate Schools and Preventure) compared to drug education as usual. This world-first study will inform national and international policy by evaluating whether prevention programs delivered in Year 8 are effective in reducing alcohol and cannabis related harms, including risk of aggression and violence, over the high risk period during young adulthood (ages 18-20).
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    Funded Activity

    DsbA Inhibitors: From Hits To Leads

    Funder
    National Health and Medical Research Council
    Funding Amount
    $882,978.00
    Summary
    Antibiotic resistance is a looming public health crisis. New antibiotics with new mechanisms of action are desperately needed. The long-term goal of this research is to develop new drugs that disarm bacteria to overcome the problem of antibiotic resistance.
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    Funded Activity

    A RCT Of Depression Prevention In Adolescents: The Future Proofing Trial

    Funder
    National Health and Medical Research Council
    Funding Amount
    $2,183,738.00
    Summary
    Prevention is better than cure. Adolescence is when 50% of mental health problems emerge. We know we can prevent depression in 22% of young people at risk. However, the major problem is providing these prevention interventions easily and universally. Using 20,000 young people, this research aims to discover how to use smartphones to deliver prevention interventions in the real world, to improve prevention rates, and to determine the triggers associated with the onset of mental health problems.
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    Funded Activity

    Assessing The Impact Of A Multi-component Intervention To Improve Dietary Intake Of Indigenous Australian Children And Their Families Living In Remote Communities

    Funder
    National Health and Medical Research Council
    Funding Amount
    $1,455,043.00
    Summary
    Sugar-sweetened beverage consumption seems to contribute to obesity and diabetes. We aim to test the impact of multi-component intervention including a school-based nutrition education program combining high levels of parental involvement plus a supportive environment to reduce sugar-sweetened beverage consumption and improve healthy eating among Indigenous Australian children and their families living in remote communities.
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    Funded Activity

    Developmental Schizotypy In The General Population: Early Risk Factors And Predictive Utility.

    Funder
    National Health and Medical Research Council
    Funding Amount
    $830,952.00
    Summary
    This study will determine early childhood risk factors for psychosis-proneness in children aged 11 years, and emerging signs and symptoms of mental health disorders of these children, using population data from the NSW Child Development Study. Determining risk for psychosis as early as possible in the life course will enable the provision of preventative interventions to children at critical points in development.
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    Funded Activity

    Development Of Next Generation Drugs For Chronic Myeloid Leukaemia

    Funder
    National Health and Medical Research Council
    Funding Amount
    $632,726.00
    Summary
    Chronic myeloid leukaemia (CML) is one of the four most common types of leukaemia. With current therapies, 15–20% of patients newly diagnosed for CML will die in the next five years, and it is therefore vitally important to discover new treatments. The aim of this project is to develop a new generation of drugs to treat CML based on new approaches (i.e., different type of molecules and different binding site) that can combat the resistance acquired to the current treatments.
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    Funded Activity

    Suicide Prevention In Schools: A Social Connectedness Approach

    Funder
    National Health and Medical Research Council
    Funding Amount
    $825,989.00
    Summary
    Suicide is the leading cause of death in Australians aged 15-24 years. This project will investigate the effectiveness of an intervention to promote help-seeking for suicidal behaviours in adolescence. Taking a whole school approach, peer leaders in 16 Australian high schools will receive training in the Sources of Strength program. The primary aim of the project is to determine whether peer leadership training and messaging improves help-seeking attitudes, intentions and behaviour for suicide.
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    Funded Activity

    Making Fetal Alcohol Spectrum Disorders History In The Pilbara: An Evidence-based Prevention Intervention

    Funder
    National Health and Medical Research Council
    Funding Amount
    $1,703,824.00
    Summary
    This project creates and evaluates a community-oriented Fetal Alcohol Spectrum Disorder prevention program. Based on an internationally recognised model, the program will be delivered through the Pilbara’s Aboriginal Health Organisations and WA Country Health Service and will assist Aboriginal women, partners, community and health providers. Program success will result in a reduction in alcohol use during pregnancy, and increased community and health providers’ knowledge, attitudes and practice.
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