Understanding The Causes Of Childhood Congenital Anomalies Of The Kidney And Urinary Tract
Funder
National Health and Medical Research Council
Funding Amount
$609,748.00
Summary
Congenital anomalies of the kidney and urinary tract (CAKUT) is a common cause of renal failure in children. The majority of patients with CAKUT do not know the underlying cause of their renal anomalies. In this proposal we will characterise the developmental events that are perturbed in three mouse models of CAKUT and identify the causal gene responsible in each mouse model. We will translate this information to the clinic by screening patients with CAKUT for mutations in these newly identified ....Congenital anomalies of the kidney and urinary tract (CAKUT) is a common cause of renal failure in children. The majority of patients with CAKUT do not know the underlying cause of their renal anomalies. In this proposal we will characterise the developmental events that are perturbed in three mouse models of CAKUT and identify the causal gene responsible in each mouse model. We will translate this information to the clinic by screening patients with CAKUT for mutations in these newly identified genes.Read moreRead less
Nasal Highflow For Paediatric Acute Hypoxic Respiratory Failure
Funder
National Health and Medical Research Council
Funding Amount
$2,627,819.00
Summary
The burden of respiratory disease in children requiring intensive care admission is increasing despite better quality care in hospitals. This study investigates a new method, called nasal high flow, to support the breathing of children, that can be provided in regular children's wards in regional and metropolitan hospitals. The study anticipates to demonstrate that early intervention with nasal high flow reduces the need for intensive care admission.
Retinal Photography To Assess Early Kidney Development In Indigenous Babies
Funder
National Health and Medical Research Council
Funding Amount
$888,098.00
Summary
The objective of this study is to identify infants who are at high risk off subsequent kidney failure . To achieve this objective, we plan to carry out comparison of kidney growth and function between Aboriginal and and non-Aboriginal infants from birth until they are 2 years old. We also hope to determine if changes in the blood vessels in these infants' eyes correspond to changes in the growing kidney- we are trying to determine if the eyes are the windows to the growing kidneys.
We have shown that premature birth leads to abnormalities in kidney structure and function. This project will determine in human infants, whether premature birth when combined with poor growth in the womb leads to an increase in these kidney abnormalities. Using animal studies we will examine specific factors which may adversely impact on kidney growth before and after premature birth. The findings are very relevant to the long-term kidney health of indigenous Australians.
Non-invasive Methods Of Measuring Work Of Breathing In Children
Funder
National Health and Medical Research Council
Funding Amount
$41,267.00
Summary
Sleep-disordered breathing such as obstructive sleep apnoea, is currently diagnosed if a child stops breathing more than once per hour. For children with asthma or cystic fibrosis, who may not stop breathing during the night, how hard their breathing muscles work can have a significant impact on their health. A non-invasive method of measuring respiratory effort, and incorporating this measurement into how sleep-disordered breathing is diagnosed, can revolutionize how sleep-disordered breathing ....Sleep-disordered breathing such as obstructive sleep apnoea, is currently diagnosed if a child stops breathing more than once per hour. For children with asthma or cystic fibrosis, who may not stop breathing during the night, how hard their breathing muscles work can have a significant impact on their health. A non-invasive method of measuring respiratory effort, and incorporating this measurement into how sleep-disordered breathing is diagnosed, can revolutionize how sleep-disordered breathing in children are managed world-wide.Read moreRead less