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Sperm Methylation Status Predicts Embryo And Pregnancy Outcomes In Male Obesity
Funder
National Health and Medical Research Council
Funding Amount
$358,411.00
Summary
The incidence of male obesity in reproductively age men is epidemic and continually rising with close to 70% of men of reproductive age classified as overweight or obese. Male obesity is not only associated with sub fertility but also changes to pregnancy outcomes and influencing child health. This project will try to uncover the molecular changes in sperm, providing potential mechanisms for the abnormal foetal and pregnancy health seen as a result of male obesity.
What, When, And How To Treat Adolescents With Obesity: Generating Evidence For Clinical Dietetic Practice
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This fellowship will advance the treatment of obesity at a critical time in a person’s life, adolescence. Without effective treatment, obesity in adolescence will likely continue into adulthood, but adolescents are suffering from obesity related conditions such as type 2 diabetes now. By assessing a novel dietary treatment and investigating the most effective time and ways to intervene, this research will diminish the tidal wave of future disease burden that adolescent obesity entails.
The Genetic And Environmental Risk For Pregnancy Complications And Subsequent Metabolic Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$350,891.00
Summary
The major problems in late pregnancy are preeclampsia, gestational diabetes and babies who are small or are born prematurely. Women who develop these pregnancy complications and men who father them are at risk of later life coronary heart disease (CHD). The purpose of this study is to develop tests to identify couples at risk of CHD early in pregnancy. If we can predict this risk early, targeted interventions can be implemented to reduce the risk of pregnancy complications and subsequent CHD.
The first kernels of cardiovascular disease begin very early in life; in the womb and early infancy. These early indications are known to track into adulthood, eventually resulting in diseases such as heart attacks. Dr Huang has found that childhood obesity, high blood pressure, cholesterol and a "prediabetes" profile, cluster together and additionally are associated with many factors in the womb and first few years of life. She investigates how to give babies the optimal healthy start.
Molecular Profiling Of The Immunoglobulin Proteome In Primary Sjögren’s Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$322,460.00
Summary
Primary Sjögren’s syndrome is a common autoimmune disease. The patients have high levels of circulating immunoglobulins (Igs) in their blood-a hallmark of the disorder. The applicant proposes to sequence these Igs and identify their so-called variable region molecular signatures. These signatures can then be used in a mass spectrometric-based diagnostic platform to identify unique clones in patients as early markers of the disease process, and hopefully lead to more relevant diagnostic markers.
Polycystic ovary syndrome (PCOS) affects a striking 9-21% of women of reproductive age. PCOS is an important health problem and can affect menstrual cycles, fertility and increase risk of diabetes and mood disorders. There is a lack of longitudinal studies that women with PCOS over time to examine the key determinants of PCOS, long-term impact of obesity and factors contributing to PCOS complications.