Interaction Of TRP Channels And Inflammatory Mediators: A Critical Role In Visceral Pain
Funder
National Health and Medical Research Council
Funding Amount
$308,747.00
Summary
Transient receptor potential, or TRP channels, are involved in generating many of the sensations we feel, such as touch and pain. The function of these channels can be altered by substances released by the body during inflammation. Some TRP channels have specialized roles in signalling pain from the colon which can be enhanced during colonic inflammation. Understanding how TRP channels and inflammatory mediators function and interact is essential if we are to find treatments for colonic pain.
Higher Line Bundles in Geometry and Physics. This project seeks to develop a theory of geometric objects, `higher line bundles', which realise elements of higher dimensional cohomology groups. In particular this project will develop a theory of differential geometry for these objects, allowing one to interpret differential forms representing cohomology classes as the `curvature' of a higher line bundle. This will have applications in quantum field theory and string/brane theory.
Neourobiology Of Human Epilepsy: Genes, Cellular Mechanisms,network And Whole Brain
Funder
National Health and Medical Research Council
Funding Amount
$17,652,824.00
Summary
The team is comprised of neurologists, molecular geneticists, physiologists and brain imaging specialists and leads the world in the discovery of the genetic causes of epilepsy. They will continue to identify genes underlying epilepsy and study how genetic variations result in development of seizures. Advanced brain imaging will be used to understand the effects of genetic variation on brain structure and function. This study may lead to new diagnostic methods and treatments for epilepsy.
Global aspects of dualities in String Theory in the presence of background fluxes. String Theory, known to the general public as the "Theory of Everything', is currently an extremely active area of research internationally. It has not only stimulated considerable interaction between mathematical physicists and mathematicians, but also increased public interest in science through television programs and books. Unfortunately, the majority of the Australian scientific community has not yet caught ....Global aspects of dualities in String Theory in the presence of background fluxes. String Theory, known to the general public as the "Theory of Everything', is currently an extremely active area of research internationally. It has not only stimulated considerable interaction between mathematical physicists and mathematicians, but also increased public interest in science through television programs and books. Unfortunately, the majority of the Australian scientific community has not yet caught up with these developments. Our recent papers, all published in premier journals in this field, have not only received widespread international attention but have also increased the profile of String Theory amongst Australia's mathematicians and mathematical physicists. The proposed project is expected to continue this trend.Read moreRead less
Twisted K-theory and its application to String Theory and Conformal Field Theory. String Theory is, at present, the only consistent theory of quantum gravity. Recently, twisted K-theory was proposed as the algebraic structure underlying the classification of D-branes, i.e. solitonic extended objects, in certain closed string backgrounds. In this project we aim to advance our understanding of the properties of twisted K-theory in the context of String Theory and Conformal Field Theory. The ult ....Twisted K-theory and its application to String Theory and Conformal Field Theory. String Theory is, at present, the only consistent theory of quantum gravity. Recently, twisted K-theory was proposed as the algebraic structure underlying the classification of D-branes, i.e. solitonic extended objects, in certain closed string backgrounds. In this project we aim to advance our understanding of the properties of twisted K-theory in the context of String Theory and Conformal Field Theory. The ultimate goal is to find the appropriate K-theory classifying D-branes in arbitrary closed string backgrounds or, similarly, classifying boundary Conformal Field Theories. It has already emerged that the K-theory of C*-algebras will play an important role.Read moreRead less
Dualities in String Theory and Conformal Field Theory in the context of the Geometric Langlands Program. The Langlands program ties together seemingly unrelated areas of Mathematics. Recently, in the context of the Geometric Langlands correspondence, novel connections with Theoretical Physics have emerged, thus becoming one of the most active areas of research in both Mathematics and Theoretical Physics. Australia has a number of world-renowned experts, including the two CI's, in various aspect ....Dualities in String Theory and Conformal Field Theory in the context of the Geometric Langlands Program. The Langlands program ties together seemingly unrelated areas of Mathematics. Recently, in the context of the Geometric Langlands correspondence, novel connections with Theoretical Physics have emerged, thus becoming one of the most active areas of research in both Mathematics and Theoretical Physics. Australia has a number of world-renowned experts, including the two CI's, in various aspects of the Langlands program, and is therefore well-placed to make seminal contributions. Being involved in these new developments is of crucial importance to the health of Mathematics and Theoretical Physics in Australia. An integral part of this proposal is student involvement and postgraduate training.Read moreRead less
Fractional analytic index theory. Atiyah-Singer index theory, for which M.F. Atiyah and I.M. Singer received the 2004 Abel Prize, has stimulated considerable interaction between mathematicians and mathematical physicists. An extension of this theory is Fractional Index Theory, co-invented by R.B. Melrose, I.M. Singer and myself, which has received international attention, having solved a fundamental open problem. A central aim in my research project is to extend our theory to elliptic boundary ....Fractional analytic index theory. Atiyah-Singer index theory, for which M.F. Atiyah and I.M. Singer received the 2004 Abel Prize, has stimulated considerable interaction between mathematicians and mathematical physicists. An extension of this theory is Fractional Index Theory, co-invented by R.B. Melrose, I.M. Singer and myself, which has received international attention, having solved a fundamental open problem. A central aim in my research project is to extend our theory to elliptic boundary value problems. I will assist beginners to navigate to the cutting edge of research through workshops, spring-schools and supervision. Benefits include the enhancement of Australia's position in the forefront of international research.Read moreRead less
Epilepsy: Molecular Basis And Mechanisms In The Era Of Functional Genomics
Funder
National Health and Medical Research Council
Funding Amount
$12,062,533.00
Summary
The team comprises of neurologists with a special interest in epilepsy (both adult and child) molecular geneticists, physiologists and brain imaging specialists. The team leads the world in the discovery of the genetic causes of epilepsy and epilepsy associated with intellectual disability. The team will continue to identify the genes underlying epilepsy, and study how genetic variations result in the development of seizures and will continue to develop advanced imaging techniques for these stud ....The team comprises of neurologists with a special interest in epilepsy (both adult and child) molecular geneticists, physiologists and brain imaging specialists. The team leads the world in the discovery of the genetic causes of epilepsy and epilepsy associated with intellectual disability. The team will continue to identify the genes underlying epilepsy, and study how genetic variations result in the development of seizures and will continue to develop advanced imaging techniques for these studies. This will include extensive laboratory studies, including the development of mice with the exact mutations that we find in the human condition. Stateof-the-art imaging techniques with magnetic resonance and positron emission tomography are used in human subjects to further understand the effects of the mutations on the structure and function of the brain. This will allow deep understanding of how seizures develop and may lead to new diagnostic methods and treatments. The laboratory and clinical aspects of the research are tightly integrated in this internationally leading collaborative program.Read moreRead less
Chronic inflammation underlies common and debilitating diseases and causes pain by unknown mechanisms. There is an urgent need to gain a deeper understanding of the mechanisms of chronic pain, which will allow the development of improved therapies with fewer side-effects. Our research program investigates the mechanisms of pain that are associated with inflammatory bowel disease and irritable bowel syndrome, with the goal of developing more effective and selective therapies.
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.