Lively reproduction: do common molecules underlie all vertebrate live birth? Most animals lay eggs, but some (most mammals, including humans and some reptiles) give birth to live young. This project will reveal the molecules underlying the evolution of live birth and fundamental processes of early pregnancy, which potentially will lead to future developments in reproductive science.
Movement patterns and habitat utilisation of the endangered eastern freshwater cod, Maccullochella ikei Rowland. The project aims to quantify the movement patterns and habitat utilisation of the endangered eastern freshwater cod (Maccullochella ikei) at a larval, juvenile, adult and historical level. Most previous studies regarding the life-history of fish species have failed to adopt this holistic approach, with management often based on fragmented information. The project will also provide an ....Movement patterns and habitat utilisation of the endangered eastern freshwater cod, Maccullochella ikei Rowland. The project aims to quantify the movement patterns and habitat utilisation of the endangered eastern freshwater cod (Maccullochella ikei) at a larval, juvenile, adult and historical level. Most previous studies regarding the life-history of fish species have failed to adopt this holistic approach, with management often based on fragmented information. The project will also provide an insight into the biology of one of the most poorly understood coastal stream fishes of eastern-Australia and assist in ensuring the conservation of this endangered species, and offer a framework from which future studies into the life history of freshwater fish species worldwide can be based.Read moreRead less
Conservation genetics of the Endangered Oxleyan Pygmy Perch Nannoperca oxleyana. The aim of this study is to determine how isolation of populations of the endangered Oxleyan Pygmy Perch Nannoperca Oxleyana affects their genetic composition. The significance of the study is that it will enhance our ability to conserve the species, and enhance our understanding of the genetics of isolated populations of freshwater fish generally.
The link between the angiogenesis of live birth and cancer: a lizard model. The possible link between live birth and cancer will be tested in this project. Lizards that express a growth factor that helps the growth of human cancer tumours will be studied to determine the action of the factor in a whole animal and in human cancer cells.
The Origin and Evolution of the Animal Phyla inferred from Analysis of Multiple-Gene Data. Australia has recently begun an extensive research programme in the genomics of our flora and fauna. The enormous amounts of data that emerge from such research are highly complex, but they hold the key to understanding how biological organisms change over time. Our research will untangle that data to answer fundamental, unanswered questions in modern science: How did the animal groups originate? How are ....The Origin and Evolution of the Animal Phyla inferred from Analysis of Multiple-Gene Data. Australia has recently begun an extensive research programme in the genomics of our flora and fauna. The enormous amounts of data that emerge from such research are highly complex, but they hold the key to understanding how biological organisms change over time. Our research will untangle that data to answer fundamental, unanswered questions in modern science: How did the animal groups originate? How are they related to each other? How is biodiversity changing? The answers to these questions and the new analytical tools we will develop will put Australia firmly on the international "map" of Bioinformatics.Read moreRead less
Humane Chemical Methods for Population Management of Highly Valued Large Mammals. In many countries valued wild and feral animals are nonetheless too numerous. Their population numbers must be controlled through fertility. Examples are koalas in Australia, deer and seals in North America, cattle in India and dogs in Thailand. We aim to develop benign implants for castration based upon the gonadotrophin releasing hormone (GnRH). These implants are easily administered. The outcomes will be to ....Humane Chemical Methods for Population Management of Highly Valued Large Mammals. In many countries valued wild and feral animals are nonetheless too numerous. Their population numbers must be controlled through fertility. Examples are koalas in Australia, deer and seals in North America, cattle in India and dogs in Thailand. We aim to develop benign implants for castration based upon the gonadotrophin releasing hormone (GnRH). These implants are easily administered. The outcomes will be to protect Australia's ?green? image , worldwide market opportunities for the Australian companies involved in this application and valuable intellectual property for Macquarie. The methodology will in time allow us to apply it to the treatment of cancer.Read moreRead less
Genomic Basis of Resistance to Poisoning by Sodium Fluoroacetate (Compound 1080) in Australian Wildlife. In Australia agricultural conservation activities worth billions of dollars are protected by using sodium fluoroacetate (1080) against pest animals. Target species are Australian rabbits and foxes and New Zealand brushtail possums. Prolonged use of biocontrol agents causes genetic resistance. This occurs naturally in Western Australia in native animals living in areas with high levels of 1080 ....Genomic Basis of Resistance to Poisoning by Sodium Fluoroacetate (Compound 1080) in Australian Wildlife. In Australia agricultural conservation activities worth billions of dollars are protected by using sodium fluoroacetate (1080) against pest animals. Target species are Australian rabbits and foxes and New Zealand brushtail possums. Prolonged use of biocontrol agents causes genetic resistance. This occurs naturally in Western Australia in native animals living in areas with high levels of 1080 in native plants. As part of the Kangaroo Genome project our aim is to discover the genomic basis of this resistance. The outcomes will be improved ability to manage pest animal populations and understanding of the evolution of plant-animal interactions.Read moreRead less
Solving Darwin's dilemma: Molecular analysis of worker sterility in social insects. One of Darwin's greatest puzzles was how natural selection resulted in worker sterility in social insects. We now know from mathematical modelling that a gene that causes sterility in workers can be at a selective advantage if it increases the reproductive success of queens. This project will take the only known gene that causes sterility, 'Anarchy' from honey bees, and determine how this gene evolved. We will de ....Solving Darwin's dilemma: Molecular analysis of worker sterility in social insects. One of Darwin's greatest puzzles was how natural selection resulted in worker sterility in social insects. We now know from mathematical modelling that a gene that causes sterility in workers can be at a selective advantage if it increases the reproductive success of queens. This project will take the only known gene that causes sterility, 'Anarchy' from honey bees, and determine how this gene evolved. We will determine if Anarchy is the same gene that causes sterility in all social insects, or only in honey bees. The project will be at the forefront of international research by providing a molecular perspective to Darwin's greatest dilemma.
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Structural reorganization of the hymenopteran mitochondrial genome. This study will be the first detailed investigation of the evolution of mt genome reorganization, and as such it will identify the processes that shape the evolution of a molecule widely used to interpret phylogeny. A description of the processes that lead to mt genome reorganization will have a substantial impact on our understanding in two areas of mt biology; (1) the discovery of new molecular phenomena that impact on the or ....Structural reorganization of the hymenopteran mitochondrial genome. This study will be the first detailed investigation of the evolution of mt genome reorganization, and as such it will identify the processes that shape the evolution of a molecule widely used to interpret phylogeny. A description of the processes that lead to mt genome reorganization will have a substantial impact on our understanding in two areas of mt biology; (1) the discovery of new molecular phenomena that impact on the organization and evolution of this genome, and (2) the interpretation of its phylogenetic content. It will establish our research group as a leader in the field of evolutionary genetics. Training of high quality students, with exposure to international researchers, will be a significant component of this program.Read moreRead less
The evolution of insect genitalia: phallic reversal in Australian praying mantids. This project will enhance our knowledge of the evolutionary processes that drive biodiversity within species and speciation itself. These issues are fundamental to evolutionary biology, and are of great interest for the general public. We have been extraordinarily successful in communicating our research to the public via natural history articles and films. We will continue to generate high impact publications fro ....The evolution of insect genitalia: phallic reversal in Australian praying mantids. This project will enhance our knowledge of the evolutionary processes that drive biodiversity within species and speciation itself. These issues are fundamental to evolutionary biology, and are of great interest for the general public. We have been extraordinarily successful in communicating our research to the public via natural history articles and films. We will continue to generate high impact publications from this research that will increase the international research profile of Australia in the scientific community. This project will establish international collaborations between Australia and the University of Exeter in Cornwall (UK) and provide employment and high quality training to a research associate and a research assistant. Read moreRead less