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The Regulation Of Monocyte Derived Dendritic Cells (moDCs) During Allograft Rejection
Funder
National Health and Medical Research Council
Funding Amount
$110,218.00
Summary
Islet transplantation can cure type 1 diabetes, but the required drugs for immunosuppressing graft rejection have side effects. Therefore understanding how immune rejection occurs so that we can suppress in a more discreet selective way is our goal. A type of cell that is prominent during graft rejection is the monocyte derived dendritic cell. We propose that this cell is critical for orchestrating immune responses during rejection. Therefore we wish to determine how such cells are controlled.
Closed-loop Insulin Delivery Compared With Islet Cell Transplantation For Adults With Type 1 Diabetes And Impaired Awareness Of Hypoglycaemia
Funder
National Health and Medical Research Council
Funding Amount
$92,745.00
Summary
Hypoglycaemia in adults with type 1 diabetes is common. Evaluation of therapies – the ‘artificial pancreas’ and islet cell transplantation - is warranted in a cohort with repeated episodes of hypoglycaemia. This proposal will assess whether the ‘artificial pancreas’ and islet cell transplantation, compared with usual insulin therapy, will reduce hypoglycaemia and improve other clinical outcomes over 6 months. This has potential to expand therapies used in current clinical practice.
Improving Outcomes Of Transplantation By Targeting Retrieval, Care And Complications
Funder
National Health and Medical Research Council
Funding Amount
$70,750.00
Summary
Our aim is to find out what the problems related to organ transplantation are in order to suggest ways of intervening to help reduce these problems for patients and the health care system. We will work closely with the team at one of Australia's leading transplant centres at Westmead Hospital to try and find safe and economic ways to tackle issues of organ shortage, those that come up during the organ donation and in the wider care of patients improve the practice.
The Role Of Th17 And Tregs In The Development Of Tolerance And Rejection In A Murine Model Of Renal Allograft Rejection
Funder
National Health and Medical Research Council
Funding Amount
$110,068.00
Summary
In clinical transplantation, rejection remains the greatest problem in determining both short and long-term patient outcomes. Tolerance, the ability of the body to accept a transplant without immunosuppressive drugs, remains an as yet unattained goal. The aim of this project is to examine the mechanisms by which the initial immune response (innate immunity) affects the development of tolerance or rejection in a mouse model of kidney transplantation.
Eye Banks, Exports, And Australian Opinion: Exploring National Utility Of Human Corneal Tissue Donation
Funder
National Health and Medical Research Council
Funding Amount
$111,973.00
Summary
Human corneal tissue donations from the deceased can outstrip the demand of eye tissue from ophthalmologists to perform a corneal transplantation, a surgical procedure to treat blindness. This research will determine the quantity of surplus eye tissue, and community understanding of donation and support for exportation. This will help the sector with decision-making on management of oversupply and potential exporte to other countries in need.
The Impact Of The Identification And Inclusion Of Acceptable HLA-mismatches On The Transplant Potential Of Highly-sensitised Renal Transplant Candidates.
Funder
National Health and Medical Research Council
Funding Amount
$100,323.00
Summary
In Australia, allocation of donor kidneys are currently weighted largely on the degree of donor-recipient HLA compatibility. However, not all HLA mismatches leads to negative outcomes. Acceptable HLA-mismatches are antigen mismatches that can be considered compatible at a structural and functional level and have been applied to circumvent the problem of difficulty finding suitable donors for highly-sensitised transplant candidates. We apply this concept to the Australian kidney transplant popula ....In Australia, allocation of donor kidneys are currently weighted largely on the degree of donor-recipient HLA compatibility. However, not all HLA mismatches leads to negative outcomes. Acceptable HLA-mismatches are antigen mismatches that can be considered compatible at a structural and functional level and have been applied to circumvent the problem of difficulty finding suitable donors for highly-sensitised transplant candidates. We apply this concept to the Australian kidney transplant population.Read moreRead less
The Menstrual Cycle, Menopause And Gender Specific Health Needs Of Women With Complex Medical And Psychiatric Conditions.
Funder
National Health and Medical Research Council
Funding Amount
$149,982.00
Summary
The great advances in medical science mean that women are living longer, sometimes with very complex conditions.The aim of this study is to determine how common women’s health issues are in women who have had a lung or bone marrow transplant and in women with severe mental illness. The study will involve face to face interview with women and then a survey of a larger number of women. The study will help improve the care and quality of life of women who already face significant health challenges.
The Role Of Mucosal-associated Invariant T (MAIT) Cells And Gut Micro-biota In The Pathogenesis Of Paediatric Autoimmune Liver Disease (AILD).
Funder
National Health and Medical Research Council
Funding Amount
$124,676.00
Summary
Liver disease can develop when a faulty immune system attacks the liver, occasionally leading to significant liver scarring and liver transplantation. Children who develop this condition need life-long treatment, but not every child responds. I intend to study immune cells and their activity in the blood and liver of affected children. By identifying the role of the immune system in liver inflammation, we hope to find out why children develop this disease and how best to treat them.
Investigating The Function Of Natural Killer Cells During Immunological Responses Following Human Lung Transplantation
Funder
National Health and Medical Research Council
Funding Amount
$71,766.00
Summary
The immune system is critical in controlling common viral infections in healthy individuals. When transplanting foreign solid organs into patients with end-stage lung disease the immune systemÍs activity is decreased via the immunosuppressive drugs to enable graft acceptance. In some patients the immune response can detect similarities between previously encountered viruses and the foreign organ, leading to life-threatening health problems through either rejection episodes and/or graft loss.