One of the current challenges in public health is to translate the progress from the Human Genome Project into reduced morbidity and mortality from disease. Once genetic defects are characterised, knowledge about the variability in severity of disease in mutation carriers, is important from a public health perspective. Hereditary Haemochromatosis (HH) is a common genetic disorder of iron overload that results in a wide spectrum of disease, varying from non-specific symptoms to severe damage to l ....One of the current challenges in public health is to translate the progress from the Human Genome Project into reduced morbidity and mortality from disease. Once genetic defects are characterised, knowledge about the variability in severity of disease in mutation carriers, is important from a public health perspective. Hereditary Haemochromatosis (HH) is a common genetic disorder of iron overload that results in a wide spectrum of disease, varying from non-specific symptoms to severe damage to liver, heart, pancreas and joints from iron deposition. It is easily treatable by regular blood donation, and population-based screening for HH has therefore been advocated. In this study we aim to address gaps in the existing data on HH regarding dietary and lifestyle factors that contribute to the variable clinical picture of HH. The study will be based on the Melbourne Collaborative Cohort Study, a cohort of 31,500 men and women who have been followed for approximately 10 years. Information on dietary and lifestyle factors was collected at initial enrollment, along with a blood specimen. We will test all non-Southern European participants (31,176) for the common HH mutations in the HFE gene and then select a subgroup of 1150 people, including all people with the main genetic defect as well as a comparison group, for further clinical followup. Participants will have genetic counselling and informed consent will be obtained. Participants will complete a short questionnaire and give a blood sample for measurement of iron overload, liver function, and other relevant blood tests, then undergo a brief clinical examination. Results of all tests will be given at a followup visit by genetic counsellor or physician. This study will provide important data on natural history of HH risk factors that influence variability in clinical presentation and the association of HFE mutations with chronic diseases and all cause mortality.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH140100035
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Research Hub for Computational Particle Technology. ARC Research Hub for Computational Particle Technology. This research hub aims to develop and apply advanced theories and mathematical models to design and optimise particulate and multiphase processes that are widely used in the minerals and metallurgical industries. This should be achieved through detailed analysis of the fundamentals governing fluid flow, heat and mass transfer at different time and length scales, facilitated by various ....ARC Research Hub for Computational Particle Technology. ARC Research Hub for Computational Particle Technology. This research hub aims to develop and apply advanced theories and mathematical models to design and optimise particulate and multiphase processes that are widely used in the minerals and metallurgical industries. This should be achieved through detailed analysis of the fundamentals governing fluid flow, heat and mass transfer at different time and length scales, facilitated by various novel research techniques. Research outcomes including theories, computer models and simulation techniques, as well as well-trained young researchers, should have a significant impact across a range of industries of vital importance to Australia’s economic and technological future, including the minerals, metallurgical, materials, chemical, energy, pharmaceutical and environment sectors.Read moreRead less
Automated On-Line Analysis and Contaminant Detection in Mineral Ore Processing. On-belt analysis is a key to efficient functioning of several
industries involved in the mining and use of minerals. It provides
chemical analysis of the minerals as they run through the instrument
on a conveyer belt. It permits quality control and detection of
impurities. The Scantech on-line analyser is at the forefront of this
technology. Our aim is to produce novel techniques to significantly
improve and m ....Automated On-Line Analysis and Contaminant Detection in Mineral Ore Processing. On-belt analysis is a key to efficient functioning of several
industries involved in the mining and use of minerals. It provides
chemical analysis of the minerals as they run through the instrument
on a conveyer belt. It permits quality control and detection of
impurities. The Scantech on-line analyser is at the forefront of this
technology. Our aim is to produce novel techniques to significantly
improve and make more efficient the processing of data from the
analyser. A particular focus will be quicker and improved calibration
of the instrument. These techniques will increase the accuracy and
speed while reducing the costs of such analysers, thus retaining and
enhancing their competitiveness in the global market.
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Dynamics of woody vegetation and water in the central Pilbara - understanding and managing for environmental change. The development and application of technologies and knowledge for enhancing sustainable management of semi-arid environments are of high priority and significant economic, social and environmental benefit. The value of iron ore exports from the Pilbara is expected to grow by nearly 30% in the next year, while the projected production of iron ore over the next 4 years is expected t ....Dynamics of woody vegetation and water in the central Pilbara - understanding and managing for environmental change. The development and application of technologies and knowledge for enhancing sustainable management of semi-arid environments are of high priority and significant economic, social and environmental benefit. The value of iron ore exports from the Pilbara is expected to grow by nearly 30% in the next year, while the projected production of iron ore over the next 4 years is expected to be valued in excess of 60 billion dollars. However, continued and rapid expansion in the development of these resources is contingent on environmental oversight and adoption of an adaptive management approach. This research will thus make a major contribution to understanding the Pilbara ecosystems that provide tremendous economic wealth for all Australians.Read moreRead less