Using Nanotechnology To Improve The Therapeutic Efficacy Of Iron Chelators
Funder
National Health and Medical Research Council
Funding Amount
$692,769.00
Summary
Iron loading disorders (such as thalassaemia) represent an important class of human disease. As part of the treatment for these diseases, the iron needs to be removed and this is often done using iron-binding drugs known as iron chelators. Current chelators are not ideal due to side effects or onerous delivery methods. The goal of this project is to use nanotechnology to develop more effective ways of delivering chelators to improve their effectiveness and reduce toxicity.
Iron-Infection Interactions: Studies Of The Link Between Iron Metabolism And Infectious Diseases Of Global Significance
Funder
National Health and Medical Research Council
Funding Amount
$383,244.00
Summary
Anaemia, malaria and HIV affect millions of people worldwide, but interactions between these conditions are poorly understood. A haematologist with training in public health, my interest is in finding ways to control the enormous global burden of anaemia. My research will focus on how iron status influences infection with malaria and HIV. It will provide evidence for anaemia control guidelines and help improve global policies for controlling iron deficiency where these infections coexist.
Defining The Impact Of Universal Iron Interventions In Young Children: A Randomized Controlled Trial In Rural Bangladesh
Funder
National Health and Medical Research Council
Funding Amount
$2,794,373.00
Summary
Although nearly half of the world's young children are anaemic, evidence regarding the best approaches to correct this problem are limited. New data even suggests that the conventional approaches (iron supplements, multiple micronutrient powders) may even be harmful. We will perform the definitive trial which will confirm the existence and magnitude of any benefit (and harm) from these interventions in young Bangladeshi children. This trial will inform global policy on anaemia control.
Benefits And Safety Of IRon Supplementation With MAlaria Chemoprevention To Children In Malawi (IRMA) - A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$3,064,309.00
Summary
Anaemia and malaria frequently coexist in low income settings e.g. sub-Saharan Africa and Asia. Iron interventions aim to reduce anaemia but exacerbate malaria. We aim to test whether iron is made safe by coadministering malaria prevention, and whether these interventions improve child health outcomes especially cognitive development, while ensuring malaria resistance does not emerge.
Understanding The Contribution Of Iron In Traumatic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$601,263.00
Summary
Our group has discovered a novel role of amyloid precursor protein (APP) in cellular iron balance similar to another protein called ceruloplasmin (CP). Both, prevalently found in the brain, convert a damaging iron variety into the safer form. Disruption in either protein leads to cell death. We aim to establish how failure in APP and CP response may be detrimental to traumatic brain injury recovery. Understanding the iron role of APP and CP will lead to therapeutics to counter traumatic injury.
One of the current challenges in public health is to translate the progress from the Human Genome Project into reduced morbidity and mortality from disease. Once genetic defects are characterised, knowledge about the variability in severity of disease in mutation carriers, is important from a public health perspective. Hereditary Haemochromatosis (HH) is a common genetic disorder of iron overload that results in a wide spectrum of disease, varying from non-specific symptoms to severe damage to l ....One of the current challenges in public health is to translate the progress from the Human Genome Project into reduced morbidity and mortality from disease. Once genetic defects are characterised, knowledge about the variability in severity of disease in mutation carriers, is important from a public health perspective. Hereditary Haemochromatosis (HH) is a common genetic disorder of iron overload that results in a wide spectrum of disease, varying from non-specific symptoms to severe damage to liver, heart, pancreas and joints from iron deposition. It is easily treatable by regular blood donation, and population-based screening for HH has therefore been advocated. In this study we aim to address gaps in the existing data on HH regarding dietary and lifestyle factors that contribute to the variable clinical picture of HH. The study will be based on the Melbourne Collaborative Cohort Study, a cohort of 31,500 men and women who have been followed for approximately 10 years. Information on dietary and lifestyle factors was collected at initial enrollment, along with a blood specimen. We will test all non-Southern European participants (31,176) for the common HH mutations in the HFE gene and then select a subgroup of 1150 people, including all people with the main genetic defect as well as a comparison group, for further clinical followup. Participants will have genetic counselling and informed consent will be obtained. Participants will complete a short questionnaire and give a blood sample for measurement of iron overload, liver function, and other relevant blood tests, then undergo a brief clinical examination. Results of all tests will be given at a followup visit by genetic counsellor or physician. This study will provide important data on natural history of HH risk factors that influence variability in clinical presentation and the association of HFE mutations with chronic diseases and all cause mortality.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH140100035
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Research Hub for Computational Particle Technology. ARC Research Hub for Computational Particle Technology. This research hub aims to develop and apply advanced theories and mathematical models to design and optimise particulate and multiphase processes that are widely used in the minerals and metallurgical industries. This should be achieved through detailed analysis of the fundamentals governing fluid flow, heat and mass transfer at different time and length scales, facilitated by various ....ARC Research Hub for Computational Particle Technology. ARC Research Hub for Computational Particle Technology. This research hub aims to develop and apply advanced theories and mathematical models to design and optimise particulate and multiphase processes that are widely used in the minerals and metallurgical industries. This should be achieved through detailed analysis of the fundamentals governing fluid flow, heat and mass transfer at different time and length scales, facilitated by various novel research techniques. Research outcomes including theories, computer models and simulation techniques, as well as well-trained young researchers, should have a significant impact across a range of industries of vital importance to Australia’s economic and technological future, including the minerals, metallurgical, materials, chemical, energy, pharmaceutical and environment sectors.Read moreRead less
Discrete particle modelling and analysis of complex particle-fluid flows. Multiphase processes are widely used in both conventional and modern industries in Australia and worldwide, however rarely reach more than 60% of design capacity because of a poor understanding of their fundamental characteristics. This project aims to overcome this problem using an extensive combined fundamental and applied approach. The resulting theories, computer models and simulation techniques will be applied to imp ....Discrete particle modelling and analysis of complex particle-fluid flows. Multiphase processes are widely used in both conventional and modern industries in Australia and worldwide, however rarely reach more than 60% of design capacity because of a poor understanding of their fundamental characteristics. This project aims to overcome this problem using an extensive combined fundamental and applied approach. The resulting theories, computer models and simulation techniques will be applied to improve process design, control and optimisation. Consequentially, productivity and Australian competitiveness will be significantly enhanced in its most important industries such as minerals, metallurgical, chemical, energy, and materials.Read moreRead less
Flow field evaluation of AusIron top submerged injection system. The top submerged gas injection system is widely used in the metallurgical industry in many metal refining processes. The AusIron process, which uses dual top submerged lances injection, has been developed recently for direct smelting of iron ore to produce pig iron using low quality coal as fuel and reductant. Successful implementation of the process requires optimum furnace design. This project aims to study fluid flow within the ....Flow field evaluation of AusIron top submerged injection system. The top submerged gas injection system is widely used in the metallurgical industry in many metal refining processes. The AusIron process, which uses dual top submerged lances injection, has been developed recently for direct smelting of iron ore to produce pig iron using low quality coal as fuel and reductant. Successful implementation of the process requires optimum furnace design. This project aims to study fluid flow within the furnace using a laboratory scale model, plant trials and numerical analysis. The project will enhance our fundamental understanding of the top submerged injection processes and assist in optimising AusIron furnace design.Read moreRead less
Multiscale modelling of the transport phenomena of liquid iron and slag in ironmaking blast furnace. Blast furnace ironmaking is a key operation in the steel industry which, with an annual turnover around $11 billion, is a significant manufacturing sector in Australia. This project, focused on the behaviour of liquid iron and slag, can generate computer models that can reliably describe the complicated multiphase flow and thermochemical processes in the furnace. The implementation of the resulta ....Multiscale modelling of the transport phenomena of liquid iron and slag in ironmaking blast furnace. Blast furnace ironmaking is a key operation in the steel industry which, with an annual turnover around $11 billion, is a significant manufacturing sector in Australia. This project, focused on the behaviour of liquid iron and slag, can generate computer models that can reliably describe the complicated multiphase flow and thermochemical processes in the furnace. The implementation of the resultant models and the new understanding should lead to long life campaigns, better operational control, decreased fuel consumption, improved productivity and reduced environmental impact. This, together with the proposed research training, is important to the development of Australia's competitive steel industry.Read moreRead less