Modelling TRPV4 Skeletal Disorders Using Human IPSCs
Funder
National Health and Medical Research Council
Funding Amount
$1,171,187.00
Summary
Inherited skeletal disorders are a significant disease burden. Many gene mutations have been defined but we only have limited understanding about how they cause the disease. We will use patient skin cells and new in vitro re-programing technology to induce them to form cartilage cells to produce “disease in a dish” models of human skeletal disorders. These models will allow us to answer questions about how specific mutations cause disease and identify potential therapies
A Scenario Planning Tool - Improving the Bikeability of Our Cities. This project aims to produce a data framework and interactive planning support tool, in collaboration with Australian government agencies, to explore various bicycle infrastructure scenarios and assess their potential impacts. This will be a game changer for the transport sector, as the lack of data-driven approaches focused on active mobility has restricted the development of evidence-based business cases for cycling infrastruc ....A Scenario Planning Tool - Improving the Bikeability of Our Cities. This project aims to produce a data framework and interactive planning support tool, in collaboration with Australian government agencies, to explore various bicycle infrastructure scenarios and assess their potential impacts. This will be a game changer for the transport sector, as the lack of data-driven approaches focused on active mobility has restricted the development of evidence-based business cases for cycling infrastructure investment, when compared to motorised transport. Benefits from this project to the nation include more informed and optimised investment in cycling, increase in cycling modal share, reduction of emissions and congestion, and improvement of safety and health outcomes from cycling.Read moreRead less
High Strength Steel Protection Bollards. Terrorist attacks cost Australians much human grief and millions of dollars. Prevention of an attack is paramount. Passive road bollards are commonly used to stop a vehicle approaching and/or entering security sensitive infrastructure. Thin-walled tubes are used to manufacture such bollards. However there is a lack of knowledge about their behaviour, and in particular high strength alloy steel bollards, when subjected to impact loads. The investigators wi ....High Strength Steel Protection Bollards. Terrorist attacks cost Australians much human grief and millions of dollars. Prevention of an attack is paramount. Passive road bollards are commonly used to stop a vehicle approaching and/or entering security sensitive infrastructure. Thin-walled tubes are used to manufacture such bollards. However there is a lack of knowledge about their behaviour, and in particular high strength alloy steel bollards, when subjected to impact loads. The investigators will apply their extensive knowledge in thin-walled tubular structures to establish the most economical means of designing high strength bollards. This knowledge will be transferred into design standards and Australia's limited defence resources.Read moreRead less
Improving external validity of stated choice experiments. This project aims to deliver more accurate estimates of choice behaviour by reducing biases due to choice task complexity in surveys as well as design artefacts. Extracting 'true' preferences is challenging, not only due to possible hypothetical bias, but also due to increasingly complex choice tasks and the existence of design artefacts. This project will investigate the latter two in the context of marketing, transport, health, and envi ....Improving external validity of stated choice experiments. This project aims to deliver more accurate estimates of choice behaviour by reducing biases due to choice task complexity in surveys as well as design artefacts. Extracting 'true' preferences is challenging, not only due to possible hypothetical bias, but also due to increasingly complex choice tasks and the existence of design artefacts. This project will investigate the latter two in the context of marketing, transport, health, and environmental economics, and proposes new methodologies to extract preferences that more closely reflect true behaviour in real markets.Read moreRead less
Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Integrating Mobility on Demand in urban transport infrastructures. Australia’s major cities are substantially challenged for public transport services due to the dispersed and low population densities, and thus, roads are at or beyond their capacity. Smarter demand-responsive public transport services are therefore needed. This project studies the viability of such a service under a variety of scenarios.
Predictive Analytics and Real-time Traffic Control for Urban Corridors. This project aims to develop predictive data analytics and real-time traffic control and safety models for multimodal management of urban corridors, serving two salient objectives: (1) optimising person-throughput of multimodal traffic; while (2) minimising safety risks for all modes. The outcome will be an automated, sensor-based platform to monitor traffic flows from all modes and make proactive and coordinated control dec ....Predictive Analytics and Real-time Traffic Control for Urban Corridors. This project aims to develop predictive data analytics and real-time traffic control and safety models for multimodal management of urban corridors, serving two salient objectives: (1) optimising person-throughput of multimodal traffic; while (2) minimising safety risks for all modes. The outcome will be an automated, sensor-based platform to monitor traffic flows from all modes and make proactive and coordinated control decisions in real-time. The expected benefits are profound; the developed algorithms and platform will significantly reduce traffic congestion, travel delays and safety risks for all modes of transport, especially for vulnerable road users (e.g. pedestrians and cyclists).Read moreRead less
iMATCH: Independent mobility, active travel and children's health. Policy interventions are used across Australia to improve children's independent mobility, to increase children's physical activity levels and social interaction, and to generate more sustainable travel behaviour, particularly for the journey to school. iMATCH provides a holistic and inter-disciplinary evaluation of policy interventions than is undertaken for most evaluations of school travel and children's travel behaviour polic ....iMATCH: Independent mobility, active travel and children's health. Policy interventions are used across Australia to improve children's independent mobility, to increase children's physical activity levels and social interaction, and to generate more sustainable travel behaviour, particularly for the journey to school. iMATCH provides a holistic and inter-disciplinary evaluation of policy interventions than is undertaken for most evaluations of school travel and children's travel behaviour policies and programs. By controlling for the influence of the built and social environment, the project will provide the necessary support to justify these policy interventions and to identify key improvements for their delivery, supporting more sustainable and healthy lifestyles for Australia's children.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100118
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
The National Cycling Data and Analysis Platform (NCDAP) . A National Cycling Data and Analytics Platform to collect, integrate and communicate new and historic data on cycling infrastructure, attitudes, and behaviours. This project will address the significant issue of data fragmentation, pilot a national cycling survey, and develop a cycling toolkit to allow exploring and testing various cycling infrastructure scenarios. The platform will provide an open access e-Infrastructure to enable tracki ....The National Cycling Data and Analysis Platform (NCDAP) . A National Cycling Data and Analytics Platform to collect, integrate and communicate new and historic data on cycling infrastructure, attitudes, and behaviours. This project will address the significant issue of data fragmentation, pilot a national cycling survey, and develop a cycling toolkit to allow exploring and testing various cycling infrastructure scenarios. The platform will provide an open access e-Infrastructure to enable tracking social and cultural changes that influence transport choices, create effective behaviour change programs and prioritise cycling infrastructure investment. This project will contribute to healthier lifestyles, reduced traffic congestion and emissions and energy efficiency of Australia’s transport sector.Read moreRead less
Multidrug Resistance Protein 1 Inhibitors To Sensitise Cancers To Chemotherapy
Funder
National Health and Medical Research Council
Funding Amount
$840,166.00
Summary
Multidrug resistance protein 1 (MRP1) is often present at high levels in cancer cells, where it pumps chemotherapy drugs back out, causing drug resistance. Inhibitors that block MRP1 would increase the effectiveness of chemotherapy. We have developed MRP1 inhibitors with promising activity in cancer cells and mouse tumours and will now develop these inhibitors for clinical application and commercialisation.