Modelling TRPV4 Skeletal Disorders Using Human IPSCs
Funder
National Health and Medical Research Council
Funding Amount
$1,171,187.00
Summary
Inherited skeletal disorders are a significant disease burden. Many gene mutations have been defined but we only have limited understanding about how they cause the disease. We will use patient skin cells and new in vitro re-programing technology to induce them to form cartilage cells to produce “disease in a dish” models of human skeletal disorders. These models will allow us to answer questions about how specific mutations cause disease and identify potential therapies
High Strength Steel Protection Bollards. Terrorist attacks cost Australians much human grief and millions of dollars. Prevention of an attack is paramount. Passive road bollards are commonly used to stop a vehicle approaching and/or entering security sensitive infrastructure. Thin-walled tubes are used to manufacture such bollards. However there is a lack of knowledge about their behaviour, and in particular high strength alloy steel bollards, when subjected to impact loads. The investigators wi ....High Strength Steel Protection Bollards. Terrorist attacks cost Australians much human grief and millions of dollars. Prevention of an attack is paramount. Passive road bollards are commonly used to stop a vehicle approaching and/or entering security sensitive infrastructure. Thin-walled tubes are used to manufacture such bollards. However there is a lack of knowledge about their behaviour, and in particular high strength alloy steel bollards, when subjected to impact loads. The investigators will apply their extensive knowledge in thin-walled tubular structures to establish the most economical means of designing high strength bollards. This knowledge will be transferred into design standards and Australia's limited defence resources.Read moreRead less
Improving external validity of stated choice experiments. This project aims to deliver more accurate estimates of choice behaviour by reducing biases due to choice task complexity in surveys as well as design artefacts. Extracting 'true' preferences is challenging, not only due to possible hypothetical bias, but also due to increasingly complex choice tasks and the existence of design artefacts. This project will investigate the latter two in the context of marketing, transport, health, and envi ....Improving external validity of stated choice experiments. This project aims to deliver more accurate estimates of choice behaviour by reducing biases due to choice task complexity in surveys as well as design artefacts. Extracting 'true' preferences is challenging, not only due to possible hypothetical bias, but also due to increasingly complex choice tasks and the existence of design artefacts. This project will investigate the latter two in the context of marketing, transport, health, and environmental economics, and proposes new methodologies to extract preferences that more closely reflect true behaviour in real markets.Read moreRead less
Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Integrating Mobility on Demand in urban transport infrastructures. Australia’s major cities are substantially challenged for public transport services due to the dispersed and low population densities, and thus, roads are at or beyond their capacity. Smarter demand-responsive public transport services are therefore needed. This project studies the viability of such a service under a variety of scenarios.
iMATCH: Independent mobility, active travel and children's health. Policy interventions are used across Australia to improve children's independent mobility, to increase children's physical activity levels and social interaction, and to generate more sustainable travel behaviour, particularly for the journey to school. iMATCH provides a holistic and inter-disciplinary evaluation of policy interventions than is undertaken for most evaluations of school travel and children's travel behaviour polic ....iMATCH: Independent mobility, active travel and children's health. Policy interventions are used across Australia to improve children's independent mobility, to increase children's physical activity levels and social interaction, and to generate more sustainable travel behaviour, particularly for the journey to school. iMATCH provides a holistic and inter-disciplinary evaluation of policy interventions than is undertaken for most evaluations of school travel and children's travel behaviour policies and programs. By controlling for the influence of the built and social environment, the project will provide the necessary support to justify these policy interventions and to identify key improvements for their delivery, supporting more sustainable and healthy lifestyles for Australia's children.Read moreRead less
Multidrug Resistance Protein 1 Inhibitors To Sensitise Cancers To Chemotherapy
Funder
National Health and Medical Research Council
Funding Amount
$840,166.00
Summary
Multidrug resistance protein 1 (MRP1) is often present at high levels in cancer cells, where it pumps chemotherapy drugs back out, causing drug resistance. Inhibitors that block MRP1 would increase the effectiveness of chemotherapy. We have developed MRP1 inhibitors with promising activity in cancer cells and mouse tumours and will now develop these inhibitors for clinical application and commercialisation.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0228900
Funder
Australian Research Council
Funding Amount
$603,000.00
Summary
Testing facility for heavily loaded bridge and barrier systems. Government and industry are increasing truck masses from current single articulated 42.5 tonne trucks to 160 tonne multi-bogie trucks. This will provide Australia with over $1 billion of potential benefits and an efficient and competitive transport industry. To capture these benefits and further progress Australia's economy, considerable collaborative research on a number of fronts must be carried out investigating how bridges and b ....Testing facility for heavily loaded bridge and barrier systems. Government and industry are increasing truck masses from current single articulated 42.5 tonne trucks to 160 tonne multi-bogie trucks. This will provide Australia with over $1 billion of potential benefits and an efficient and competitive transport industry. To capture these benefits and further progress Australia's economy, considerable collaborative research on a number of fronts must be carried out investigating how bridges and barriers can perform safely when subjected to very heavy traffic and impact loads under laboratory and typical service conditions. This application seeks funds for establishing a unique hi-tech testing facility in Australia vital for advancing such infrastructure technology.Read moreRead less
The development and application of an evaluation framework to assess transport, health and economic impacts of new urban cycling infrastructure. This project will develop and apply a more accurate and simpler approach to measure the impacts of new cycling infrastructure, than is currently available. This methodology will be applied to a new bicycle path to be built by the City of Sydney, demonstrating the full transport, environmental, health, and economic impacts on the community.
The Effects of Nano and Ultrafine Particles from Traffic Emissions on Children's Health. The socio-economic benefits to Australia will include (i) quantitative knowledge of the exposure to nano and ultrafine particles, pollutants in the centre of current scientific, medical and policy debates and (ii) a breakthrough in the scientific understanding of the specific particle properties, which have impacts on health effects. The ultimate economic benefit will be improved urban design to lower, in pa ....The Effects of Nano and Ultrafine Particles from Traffic Emissions on Children's Health. The socio-economic benefits to Australia will include (i) quantitative knowledge of the exposure to nano and ultrafine particles, pollutants in the centre of current scientific, medical and policy debates and (ii) a breakthrough in the scientific understanding of the specific particle properties, which have impacts on health effects. The ultimate economic benefit will be improved urban design to lower, in particular, children's exposure to ultrafine particles, thus reducing life long impacts, health care cost and productivity losses. The research will also place Australia at the forefront of international progress towards better methods for achieving environmental and public health sustainability.Read moreRead less