This program will investigate the strategies used by pathogenic bacteria to cause human diseases. The research will focus on how bacteria initiate infections, how they invade, cause cell and tissue damage and respond to their human host. It will also examine how the host’s innate immune system interacts with these bacteria. The results will provide new insights into host-pathogen interactions and reveal new targets for the development of novel antibacterial drugs and vaccines.
Mechanism Of Action Of Sec1p-like Proteins In Membrane Trafficking
Funder
National Health and Medical Research Council
Funding Amount
$234,936.00
Summary
One of the most important evolutionary changes that has occurred is the development of intracellular compartments. All eukaryotic cells possess numerous membrane-encased structures which provide the basis for intracellular specialisation. For example, in order to degrade unwanted components cells have developed degradative enzymes. It is vital for the cell that these enzymes are sequestered away from other cellular components to avoid destruction of valuable molecules. In addition, the cell has ....One of the most important evolutionary changes that has occurred is the development of intracellular compartments. All eukaryotic cells possess numerous membrane-encased structures which provide the basis for intracellular specialisation. For example, in order to degrade unwanted components cells have developed degradative enzymes. It is vital for the cell that these enzymes are sequestered away from other cellular components to avoid destruction of valuable molecules. In addition, the cell has developed a complex assembly line of modifications that are added to proteins in a specific order as they travel to their final destination within the cell. This necessitates the accurate passage of molecules between compartments, a process known as vesicle transport. To orchestrate the complex network of vesicular transport steps between all of the various intracellular compartments it is necessary to employ complex machinery to guide and check that these steps occur with high fidelity. The goal of our research proposal is to define the function of one of the molecules involved in this control process, the so-called Sec1p proteins. The strength of our proposal lies in the diversity of our approach. We intend to explore the molecular advantages of a relatively simple eukaryotic organism, a yeast cell, and apply the findings obtained from this cell to a more complex but highly related vesicular transport process; that of the insulin-regulated movement of a glucose transporter in mammalian fat and muscle cells. While we intend to apply our findings to the treatment of patients with diabetes, it is our ultimate goal to be able to learn more about this fundamental cell biological process so that we can apply our knowledge to understanding many different disease states.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101233
Funder
Australian Research Council
Funding Amount
$454,386.00
Summary
Addressing the Crisis of Local Visual News in Regional and Remote Australia. This project aims to measure the volume and quality of visual content on regional news platforms by diverse publishers in eight key geographic areas. It is the first in Australia to examine the full cycle from production through presentation to consumption for local visual news in a regional context. Expected project outcomes include enhanced relationships between journalists and communities, stronger regional news ecos ....Addressing the Crisis of Local Visual News in Regional and Remote Australia. This project aims to measure the volume and quality of visual content on regional news platforms by diverse publishers in eight key geographic areas. It is the first in Australia to examine the full cycle from production through presentation to consumption for local visual news in a regional context. Expected project outcomes include enhanced relationships between journalists and communities, stronger regional news ecosystems, and a more representative local visual news product. These outcomes boost the academic understanding of an understudied area, help regional Australia, including regional Indigenous Australia, see itself in the journalism that is produced in the regions, and provide commercial benefits to hard-hit news providers.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100148
Funder
Australian Research Council
Funding Amount
$460,000.00
Summary
TrISMA - Tracking Infrastructure for Social Media Analysis. Tracking infrastructure for social media analysis: The tracking infrastructure for social media analysis (TrISMA) project establishes state-of-the-art technical and organisational infrastructure for the tracking of public communication by Australian users of social media, at large scale, in real time, and for the long term, addressing a significant gap in national research infrastructure. Social media are increasingly embedded in the Au ....TrISMA - Tracking Infrastructure for Social Media Analysis. Tracking infrastructure for social media analysis: The tracking infrastructure for social media analysis (TrISMA) project establishes state-of-the-art technical and organisational infrastructure for the tracking of public communication by Australian users of social media, at large scale, in real time, and for the long term, addressing a significant gap in national research infrastructure. Social media are increasingly embedded in the Australian media ecology, and systematic analyses of how public communication takes place via social media provide rich insights into a range of issues and debates of high importance to our society.Read moreRead less
New Media and Public Communication: Mapping Australian User-Created Content in Online Social Networks. Understanding the ways people contribute to and use the Internet for a wide range of purposes is important to Australia's future from both a social and an economic perspective. Effective, evidence-based policy depends on developing a vastly improved understanding of the current level of Australians' online activities and interests. This project provides crucial, detailed baseline data on the so ....New Media and Public Communication: Mapping Australian User-Created Content in Online Social Networks. Understanding the ways people contribute to and use the Internet for a wide range of purposes is important to Australia's future from both a social and an economic perspective. Effective, evidence-based policy depends on developing a vastly improved understanding of the current level of Australians' online activities and interests. This project provides crucial, detailed baseline data on the social, cultural and technological dynamics of Australian online public communication, which can inform further government initiatives to strengthen the country's digital economy and to maximise civic engagement through media participation.Read moreRead less
Soft Infrastructure, New Media and Creative Clusters: Developing Capacity in China and Australia. The project will position Australia at the forefront of the creative industries internationally and enhance national capacities in the rejuvenation and design of creative urban precincts. A greater appreciation of, and strong links with China, particularly its design and urban sectors, will result. Australian firms will benefit through greater trade opportunities as a result.
The uses of romance for new demographics and multimedia platforms: A model of media innovation in international women's fiction publishing. The national benefit of this project is both economic and socio-cultural. Economically, it investigates new ways to produce and distribute Australian creative content for local and export markets. It identifies how branch offices of global firms can be creative offices. Culturally, it develops scenarios for maximizing the acceptance, uptake and use of digita ....The uses of romance for new demographics and multimedia platforms: A model of media innovation in international women's fiction publishing. The national benefit of this project is both economic and socio-cultural. Economically, it investigates new ways to produce and distribute Australian creative content for local and export markets. It identifies how branch offices of global firms can be creative offices. Culturally, it develops scenarios for maximizing the acceptance, uptake and use of digital technologies by both large-scale publishers and young Australians. It investigates agents along the length of the creative value chain - from authors to audiences - to determine the uses of creative fiction, identifying the features that attract / repel users of published fiction in these genres. Finally it extends the capabilities of users to create their own romance content.Read moreRead less
Social media in times of crisis: learning from recent natural disasters to improve future strategies. This project will analyse and evaluate how social media was used by emergency authorities, media organisations and citizens during recent natural disasters, including the January 2011 Queensland floods and Tropical Cyclone Yasi. The project will develop a framework for longer-term strategies for public communication during emergencies.
Swarms in Urban Villages: New Media Design to Augment Social Networks of Residents in Inner-City Developments. This study will develop advanced knowledge of how urban neighbourhood communities can be assisted to grow in healthy ways by the use of new media and ICTs. By careful attention to cultural and social assets in the community, innovations will be engendered which enhance economic and social development. This will lead to greater social inclusion, fair access to and smart use of informatio ....Swarms in Urban Villages: New Media Design to Augment Social Networks of Residents in Inner-City Developments. This study will develop advanced knowledge of how urban neighbourhood communities can be assisted to grow in healthy ways by the use of new media and ICTs. By careful attention to cultural and social assets in the community, innovations will be engendered which enhance economic and social development. This will lead to greater social inclusion, fair access to and smart use of information and services, urban sustainability and healthier local economies. Understanding the opportunities afforded by digital augmentation of social networks will help Australians negotiate the complex web of daily choices, access a greater social safety net and participate in the socio-cultural and socio-economic life of their neighbourhood and city.Read moreRead less
Young People, Technology, and Wellbeing Research Facility. Large numbers of initiatives now mobilise technology to support the wellbeing of young Australians. However, amongst communities undertaking this work, there is currently significant duplication and insufficient sharing of research and best practice models. A Research Facility that consolidates existing research, and guides new research and initiatives will improve service delivery to young Australians by: reducing duplication between or ....Young People, Technology, and Wellbeing Research Facility. Large numbers of initiatives now mobilise technology to support the wellbeing of young Australians. However, amongst communities undertaking this work, there is currently significant duplication and insufficient sharing of research and best practice models. A Research Facility that consolidates existing research, and guides new research and initiatives will improve service delivery to young Australians by: reducing duplication between organizations working with young people; providing an accessible interface with research that can help address the community’s concerns about the role of technology in young people’s lives, and inform future policy and programs; and model effective cross-sector knowledge brokering to Australian industry. Read moreRead less