Evolution And Function Of A Novel Lateral Flagellar Locus, Flag-2, In Pathogenic Escherichia Coli
Funder
National Health and Medical Research Council
Funding Amount
$465,158.00
Summary
This project will study how the bacteria that cause infant diarrhoea colonize the intestine and induce disease. We have identified a novel genetic region that allows E. coli to survive and persist in the intestine. Similar genes are also present in closely related organisms. This project will help us to undestand how new diseases evolve and emerge and may lead to the development of new vaccines to protect against infant diarrhoea.
Barrett's oesophagus (BO) is a condition that arises in some patients with chronic reflux (heartburn) and increases the risk of developing cancer of the oesophagus. However, the exact mechanisms involved in its development are unknown. This project aims to investigate how a protein called sonic hedgehog might be involved using novel cell culturing techniques that allow us to model the growth of oesophageal tissue in the laboratory. This could lead to development of new therapies for treating BO.
Tracking the molecular dynamics of adaptation with horizontal gene transfer. This project aims to track the dynamics of adaptation with gene exchange by building the first experimental evolution model that can directly observe this process. The acquisition of genes from other strains and species (horizontal gene transfer) frequently underlies bacterial adaptation, but it is unknown how this occurs. This project aims to shift understanding of how microbial populations respond to environmental cha ....Tracking the molecular dynamics of adaptation with horizontal gene transfer. This project aims to track the dynamics of adaptation with gene exchange by building the first experimental evolution model that can directly observe this process. The acquisition of genes from other strains and species (horizontal gene transfer) frequently underlies bacterial adaptation, but it is unknown how this occurs. This project aims to shift understanding of how microbial populations respond to environmental challenges. There are significant benefits to be gained from understanding how microbes adapt in response to climate change and the widespread application of antibiotics, given that microbial populations form intimate associations with humans and sustain all of the world’s ecosystems.Read moreRead less
An integrated mechanistic model of species' responses to environmental change: from individual responses to range shifts and beyond. To effectively adapt to future environmental change, reliable forecasts are needed of how human alterations to climate and habitat will affect species. This project integrates cutting-edge methods in nutritional, physiological and spatial ecology to develop new tools for predicting and understanding how species will respond to environmental change.
Experimental co-evolution of Yeast and E. coli. This project aims to measure the rates and genetic mechanisms of adaptation for individual species within a microbial community. Expected outcomes of this interdisciplinary project include the first genomic and phenotypic dataset of a model microbial community, and novel tools for the analysis of meta-genomic datasets. This project has the potential to transform understanding of microbial adaptation.
Fires, black carbon, greenhouse gas emissions and the carbon balance of southern sclerophyll forests. Ecologically sustainable forest management requires an understanding of the role of fire in the carbon balance of native forests, and in Australia's overall carbon balance. Fires are crucial to both this carbon balance and to the ecology of the forests. This project will help forest managers make decisions about using prescribed fire to manage fuels while at the same time managing carbon. An ....Fires, black carbon, greenhouse gas emissions and the carbon balance of southern sclerophyll forests. Ecologically sustainable forest management requires an understanding of the role of fire in the carbon balance of native forests, and in Australia's overall carbon balance. Fires are crucial to both this carbon balance and to the ecology of the forests. This project will help forest managers make decisions about using prescribed fire to manage fuels while at the same time managing carbon. An aim of management is to identify fire regimes that will optimise the carbon outcome as well as provide protection to life and property. This project will help managers meet that aim by developing a quantitative understanding of how much stable, black carbon (charcoal) is produced and how it affects other soil processes.Read moreRead less
Predicting adaptive responses to climate change in Australian native bees. This project aims to understand how insects will adapt to climate change by examining a largely overlooked but economically important group of species: Australian native bees. Native bees are important pollinators of both crops and native plants, but their sensitivity to changes in climate are unknown. Expected outcomes include new knowledge of the resilience of native bees to climate change, and new effective tools for p ....Predicting adaptive responses to climate change in Australian native bees. This project aims to understand how insects will adapt to climate change by examining a largely overlooked but economically important group of species: Australian native bees. Native bees are important pollinators of both crops and native plants, but their sensitivity to changes in climate are unknown. Expected outcomes include new knowledge of the resilience of native bees to climate change, and new effective tools for predicting climate change resilience that can be applied to many species. The intended benefits include increasing our understanding of the potential for native bees to act as future pollinators in Australia’s natural and agro-ecosystems, and guide policy and management decisions to better protect and conserve our bee fauna.Read moreRead less
Evolutionary limits. This project aims to understand the processes that limit adaptation to rapid environmental change. Adaption to rapid environmental change determines population persistence. Species with restricted distributions may lack the genetic variation necessary to adapt to changing environments, although they represent the vast majority of biodiversity. Understanding why they lack the necessary genetic variation for adaptation is important for identifying and managing vulnerable biolo ....Evolutionary limits. This project aims to understand the processes that limit adaptation to rapid environmental change. Adaption to rapid environmental change determines population persistence. Species with restricted distributions may lack the genetic variation necessary to adapt to changing environments, although they represent the vast majority of biodiversity. Understanding why they lack the necessary genetic variation for adaptation is important for identifying and managing vulnerable biological systems. This project will empirically determine the contribution of mutations to key traits to better understand what limits evolutionary adaptation. Better prediction of extinction risk should inform conservation and biodiversity management.Read moreRead less
Integrating evolution and plasticity into predictions of population persistence in a changing climate: adaptation or extinction? To effectively manage biodiversity at a time of rapid environmental change, Australia needs accurate predictions of how human alterations to climate and habitat will affect species. This project integrates evolution and spatial ecology to develop new tools for predicting and understanding how species will respond to environmental change.
Evolution in tooth and claw: exploring the relationship between the radiation of marsupial herbivores and late Cenozoic climate change. Establishing how animals responded to past environmental changes is essential for understanding the ecology of modern species and managing them in light of contemporary climatic trends. By applying several novel analytical methods this project will unravel the links between the radiation of Australian marsupials and key stages in climatic evolution.