Evolution And Function Of A Novel Lateral Flagellar Locus, Flag-2, In Pathogenic Escherichia Coli
Funder
National Health and Medical Research Council
Funding Amount
$465,158.00
Summary
This project will study how the bacteria that cause infant diarrhoea colonize the intestine and induce disease. We have identified a novel genetic region that allows E. coli to survive and persist in the intestine. Similar genes are also present in closely related organisms. This project will help us to undestand how new diseases evolve and emerge and may lead to the development of new vaccines to protect against infant diarrhoea.
Barrett's oesophagus (BO) is a condition that arises in some patients with chronic reflux (heartburn) and increases the risk of developing cancer of the oesophagus. However, the exact mechanisms involved in its development are unknown. This project aims to investigate how a protein called sonic hedgehog might be involved using novel cell culturing techniques that allow us to model the growth of oesophageal tissue in the laboratory. This could lead to development of new therapies for treating BO.
Explaining biodiversity. Why are there many species in some places and not in others? The aim of this project is to understand this in order to protect species, understand invasion and restore ecological systems. Using published food webs, this project will determine what factors underlie biodiversity, then use experiments to understand effects of habitat loss and climate change on food web structure.
Islands of rocks: geckos as a model system to understand patterns of biodiversity, endemism and speciation in the Kimberley. Australia is renowned for its diversity of lizards, yet a plethora of new "cryptic" gecko species continue to be discovered. The project will densely sample the complex Kimberley to understand the evolution of its geckos, which will shed light on true levels of species diversity and the geological and environmental history of this biodiversity hotspot.
Restoring resilience in wildlife populations. This project will be the first to develop landscape models of habitat quality for wildlife that are based on a mechanistic, animal-centric approach to quantifying habitat. This will be an important step in understanding the habitat elements that wildlife need to live in altered landscapes, with implications central to restoration and revegetation.
Biotic connectivity within the temperate Australian marine protected area network at three levels of biodiversity, communities, populations and genes. Project outcomes will improve management of coastal biodiversity through a multi-state collaboration of managers, marine ecologists, population geneticists and taxonomists. Sites most needed within marine protected area (MPA) networks for maintaining resilience of populations across seascapes will be identified, including sites with exceptional en ....Biotic connectivity within the temperate Australian marine protected area network at three levels of biodiversity, communities, populations and genes. Project outcomes will improve management of coastal biodiversity through a multi-state collaboration of managers, marine ecologists, population geneticists and taxonomists. Sites most needed within marine protected area (MPA) networks for maintaining resilience of populations across seascapes will be identified, including sites with exceptional endemism or key roles in dispersal of larvae. The ecological efficacy of the temperate Australian MPA network will be assessed through analysis of long-term ecological datasets and further development of a novel 'remote sensing' methodology, whereby surveys are undertaken by volunteer divers across much greater spatial and temporal scales than could be studied by dedicated scientific dive teams.Read moreRead less
Vegetation change in coastal Parks and Reserves: risk assessment and management of woody invaders. Coastal heath ecosystems contain some of the highest diversity of plant species for any vegetation type within temperate Australia. These communities exist within and outside the Reserve system, but even those within Parks and Reserves may be undergoing rapid change in structure and composition as a result of invading environmental weeds, resulting in a significant loss of biological diversity. As ....Vegetation change in coastal Parks and Reserves: risk assessment and management of woody invaders. Coastal heath ecosystems contain some of the highest diversity of plant species for any vegetation type within temperate Australia. These communities exist within and outside the Reserve system, but even those within Parks and Reserves may be undergoing rapid change in structure and composition as a result of invading environmental weeds, resulting in a significant loss of biological diversity. As agriculture, tourism and other developments place increasing pressure on these diminishing ecosystems, the maintenance of their biodiversity takes on increasing importance. This project will identify threatening processes and devise cost-effective, practicable management strategies in a context of competing stakeholder interests.Read moreRead less
Developing Assisted Reproductive Technologies for the Conservation of Critically Endangered Australian Amphibians. Unprecedented rates of species extinction are of global concern. Although high extinction rates are reported for all vertebrate classes, amphibians are the most severely affected. Captive-breeding programs play a key role in maintaining populations of endangered amphibian species, but in most cases reproductive rates are too low to support long term re-introduction programmes. This ....Developing Assisted Reproductive Technologies for the Conservation of Critically Endangered Australian Amphibians. Unprecedented rates of species extinction are of global concern. Although high extinction rates are reported for all vertebrate classes, amphibians are the most severely affected. Captive-breeding programs play a key role in maintaining populations of endangered amphibian species, but in most cases reproductive rates are too low to support long term re-introduction programmes. This study aims to develop sophisticated Assisted Reproductive Technologies (ART) to enhance the propagation and genetic management of endangered Australian frog species. ART is a powerful new approach to ex situ conservation that, if integrated into existing captive breeding programs, will ensure the preservation of Australia’s unique amphibian biodiversity.Read moreRead less
Genetic rescue of Australian wildlife. Genetic rescue of Australian wildlife. This project aims to test genetic rescue as an efficient recovery technique for threatened plants and animals. Genetic rescue is under-utilised, even though it is overwhelmingly beneficial. This project will convert management actions on five Endangered/Critically Endangered species into rigorous experiments that measure the fitness benefits of genetic rescue, and demonstrate genome-wide consequences. Anticipated outco ....Genetic rescue of Australian wildlife. Genetic rescue of Australian wildlife. This project aims to test genetic rescue as an efficient recovery technique for threatened plants and animals. Genetic rescue is under-utilised, even though it is overwhelmingly beneficial. This project will convert management actions on five Endangered/Critically Endangered species into rigorous experiments that measure the fitness benefits of genetic rescue, and demonstrate genome-wide consequences. Anticipated outcomes include innovative genetic rescue protocols, a framework for genetic rescue, and leading-edge conservation training. Expected benefits are increased persistence of species that are otherwise unresponsive to management, and a new path to saving endangered species.Read moreRead less
Onsets not offsets for real biodiversity gains. This project addresses the profound challenge of reconciling development and biodiversity conservation by developing an alternative to the pervasive, yet unsuccessful, biodiversity offsetting approach. It will generate new knowledge in the areas of novel ecosystem function, land use optimisation and conservation attitudes. Key project outcomes will be a new framework for biodiversity onsetting, tested against environmental and social feasibility me ....Onsets not offsets for real biodiversity gains. This project addresses the profound challenge of reconciling development and biodiversity conservation by developing an alternative to the pervasive, yet unsuccessful, biodiversity offsetting approach. It will generate new knowledge in the areas of novel ecosystem function, land use optimisation and conservation attitudes. Key project outcomes will be a new framework for biodiversity onsetting, tested against environmental and social feasibility metrics, and new biodiversity evaluation methods for novel habitats. The project will provide environmental and economic benefits by reversing the ongoing decline in biodiversity from habitat loss and driving innovation in environmentally destructive industries that are vulnerable to climate change.Read moreRead less