Evolution And Function Of A Novel Lateral Flagellar Locus, Flag-2, In Pathogenic Escherichia Coli
Funder
National Health and Medical Research Council
Funding Amount
$465,158.00
Summary
This project will study how the bacteria that cause infant diarrhoea colonize the intestine and induce disease. We have identified a novel genetic region that allows E. coli to survive and persist in the intestine. Similar genes are also present in closely related organisms. This project will help us to undestand how new diseases evolve and emerge and may lead to the development of new vaccines to protect against infant diarrhoea.
Barrett's oesophagus (BO) is a condition that arises in some patients with chronic reflux (heartburn) and increases the risk of developing cancer of the oesophagus. However, the exact mechanisms involved in its development are unknown. This project aims to investigate how a protein called sonic hedgehog might be involved using novel cell culturing techniques that allow us to model the growth of oesophageal tissue in the laboratory. This could lead to development of new therapies for treating BO.
Glucose is a critical fuel for living organisms and its presence in the gut triggers nerves that slow stomach emptying. However, little is known of how glucose is actually detected in the gut. We have established that sweet taste molecules of the tongue are also present in the gut, where they may detect glucose. This research will measure the expression and function of these molecules in the gut of humans and mice, and reveal key information on their potential as targets in health and disease.