Provable elimination of information leakage through timing channels. This project aims to develop techniques to solve the issue in information security of unauthorised information flow resulting from competition for shared hardware resources. The project will combine operating systems design, formal hardware models, information-flow reasoning and theorem proving to achieve a goal that is widely considered infeasible. The project is expected to result in a system that prevents leakage of critical ....Provable elimination of information leakage through timing channels. This project aims to develop techniques to solve the issue in information security of unauthorised information flow resulting from competition for shared hardware resources. The project will combine operating systems design, formal hardware models, information-flow reasoning and theorem proving to achieve a goal that is widely considered infeasible. The project is expected to result in a system that prevents leakage of critical information, such as encryption keys, through timing channels. This should prevent sophisticated attacks on public clouds, mobile devices and military-grade cross-domain devices.Read moreRead less
Grey literature, policy innovation and access to knowledge: realising the value of informal publishing. This project examines the growth of informal research publishing, 'grey literature' in Australia, and the policies and practices that shape it. The project will make recommendations for producers, collecting institutions and policy-makers on how to maximise the considerable social and cultural benefit of 'grey literature'.
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
Humanisation And Pre-clinical Validation Of A Therapeutic Anti-cancer Antibody
Funder
National Health and Medical Research Council
Funding Amount
$699,136.00
Summary
This grant will develop a novel antibody against a protease expressed on cancer cells. Preclinical studies, and antibody humanisation, will be performed. This project will also provide vital information on optimal therapeutic approaches with the antibody that can be ultimately taken into human trials.
Amplifying public value: Scholarly contributions’ impact on public debate. Amplifying public value: Scholarly contributions’ impact on public debate. This project aims to improve the international evidence base for the public impact and value of publicly funded scholarly research, using mixed-methods analysis. Publicly funded researchers and agencies are increasingly expected to provide more detailed and transparent information about how their research is publicly valuable, contributes to public ....Amplifying public value: Scholarly contributions’ impact on public debate. Amplifying public value: Scholarly contributions’ impact on public debate. This project aims to improve the international evidence base for the public impact and value of publicly funded scholarly research, using mixed-methods analysis. Publicly funded researchers and agencies are increasingly expected to provide more detailed and transparent information about how their research is publicly valuable, contributes to public debate, and forms opinions.Read moreRead less
ADAM Metalloprotease Inhibition For Treatment Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$770,925.00
Summary
Colorectal cancer (CRC) causes over 4000 deaths/year, typically from developing drug resistance and spreading to other organs (metastasis). These processes involve tumour cells called cancer stem cells (CSCs), which rely on specific cell surface proteins for survival and function. We are developing antibodies against one of these type of proteins, to test in mouse models of CRC. These already show promise in targeting CSCs and inhibiting drug-resistance and metastasis in mice.
A Randomised Trial Of The Augmentation Of Cognitive Behaviour Therapy With Fluoxetine For Anxious School Refusing Youth
Funder
National Health and Medical Research Council
Funding Amount
$539,191.00
Summary
School refusing youth consistently suffer from anxiety and sometimes depression. They become severely emotionally distressed when taken to school and experience social and academic difficulties in the short and long term as well as psychiatric illness in adulthood. Our program investigates whether treatment can be improved by enhancing psychotherapy (cognitive behaviour therapy) which helps over half of anxious school refusing children, with antidepressant-anxiety medication compared to placebo.
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revol ....ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revolutionizing diagnosis and therapy in many diseases. The CoE will be the focus of bio-nano research activity in Australia, uniting universities, research agencies, institutes and companies. The expected outcomes are better diagnostic and therapeutic tools designed via an enhanced understanding of the bio-nano-interface.Read moreRead less