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Modelling of Bypass Pneumatic Conveying Systems. Many of the physical items we use in our daily lives have at some point required transport and handling as powdered or granular materials during the manufacturing process. Be it food (sugar, flour), chemicals (soap powders, detergents) or power generation (coal and ash); each of these industries uses the flexibility of pipelines as a transport mechanism. However, not all materials will convey reliably in conventional pipelines. This project will ....Modelling of Bypass Pneumatic Conveying Systems. Many of the physical items we use in our daily lives have at some point required transport and handling as powdered or granular materials during the manufacturing process. Be it food (sugar, flour), chemicals (soap powders, detergents) or power generation (coal and ash); each of these industries uses the flexibility of pipelines as a transport mechanism. However, not all materials will convey reliably in conventional pipelines. This project will provide the fundamental understanding of how bypass systems can overcome this problem by conditioning the material along the pipeline length. The results will lead to better pipeline design outcomes that will ultimately expand the use of the cost effective process of pneumatic pipeline conveying. Read moreRead less
Efficient Strategies for Coordinating Autonomous Vehicles for Maximising Australia's Waterfront Productivity. This project will lift the productivity of container terminals by enabling the effective deployment of autonomous vehicles in large numbers. The project outcomes of practically deployable and scalable algorithms, realised as live software, will significantly enhance Patrick Stevedores Holdings' world leading technology and the potential of such automation systems to revolutionise materia ....Efficient Strategies for Coordinating Autonomous Vehicles for Maximising Australia's Waterfront Productivity. This project will lift the productivity of container terminals by enabling the effective deployment of autonomous vehicles in large numbers. The project outcomes of practically deployable and scalable algorithms, realised as live software, will significantly enhance Patrick Stevedores Holdings' world leading technology and the potential of such automation systems to revolutionise material handling around the globe. Beyond the benefits of technology commercialisation, the project will also benefit Australia economically through extending its leading role in developing autonomous systems for material handling, enhancing the frontier technologies for building Australian industries, and alleviating looming capacity constraints.Read moreRead less
The Social Impact of the Transformation of Asia-Pacific Ports. The Asia-Pacific is the fastest growing region of maritime trade. Globalisation has resulted in changed management and ownership structures for ports with implications for labour relations, dockland redevelopment and relations with their social and economic hinterlands. These changes have social and environmental consequences, that are especially stark in the developing countries in the Asia-Pacific. While environmental issues have b ....The Social Impact of the Transformation of Asia-Pacific Ports. The Asia-Pacific is the fastest growing region of maritime trade. Globalisation has resulted in changed management and ownership structures for ports with implications for labour relations, dockland redevelopment and relations with their social and economic hinterlands. These changes have social and environmental consequences, that are especially stark in the developing countries in the Asia-Pacific. While environmental issues have been thoroughly expolored, social transformations and impacts are poorly understood. We a suitable conceptual framework and methodology to anticipate, manage and assess the implication of change. This project seeks to conceptualise, compare and measure the social impact of changes to Asia-Pacific ports.Read moreRead less
Mechanisms Involved In Reduced Cardiac Contractility As A Consequence Of Growth Restriction During Fetal Development
Funder
National Health and Medical Research Council
Funding Amount
$317,810.00
Summary
Functional development of the heart muscle has been a focus of intense research over the last 40 years. Despite our current understanding of the changes in how excitation of the cardiomyocyte leads to contraction, a process broadly termed excitation-contrcation (E-C) coupling, a major model used to study paralells of human fetal development, the sheep, has not been examined in this context. As such, it remains unclear how E-C coupling evolves from the fetus to the adult. Understanding normal phy ....Functional development of the heart muscle has been a focus of intense research over the last 40 years. Despite our current understanding of the changes in how excitation of the cardiomyocyte leads to contraction, a process broadly termed excitation-contrcation (E-C) coupling, a major model used to study paralells of human fetal development, the sheep, has not been examined in this context. As such, it remains unclear how E-C coupling evolves from the fetus to the adult. Understanding normal physiology is imperative to subsequetly understand pathological states, such as interuterine growth restriction (IUGR). In Australia, the incidence of IUGR leading to low birth weight babies is 7%. IUGR is caused by maternal undernutrition, maternal smoking-drug use and placental insufficiency. It is associated with an increase in perinatal mortality, respiratory problems, SIDS and morbidity. Epidemiological studies show that low birth weight babies are also at an increased risk of cardiovascular disease, including heart failure, in adult life. To date, there is little information on the impact of fetal growth restriction on the normal development and function of the heart muscle. Understanding the impact of IUGR on heart muscle development will allow the elucidation of the underlying physiological mechanisms linking these two temporally distinct events. This mechanistic understanding will allow improved clinical management of those individuals at risk of cardiovascular disease in adult life arising from IUGR. It may also allow for early intervention strategies that can improve cardiovascular function. Therefore, we propose to examine both the normal developmental changes to E-C coupling so that we can understand how placental insufficiency leading to IUGR impairs normal heart muscle development. This will result in impaired function at a cellular level, which will ultimately manifest as an increased susceptibility of the heart to injury in later life.Read moreRead less
The Effect Of Dietary Fatty Acids On Cellular Calcium Handling Mechanisms In Cardiac Muscle
Funder
National Health and Medical Research Council
Funding Amount
$275,765.00
Summary
A major health problem in the developed countries is cardiovascular disease, which is manifest as high blood pressure, stroke, heart attack and abnormalities of heart rhythm, or cardiac arrhythmias. A western diet, ie. one high in animal fat, or saturated fats, may be to blame. Human epidemiological studies have shown that consumption of a diet high in saturated fats is correlated with a propensity to arrhythmias while a diet high in polyunsaturated fatty acids (PUFAs) can confer protection from ....A major health problem in the developed countries is cardiovascular disease, which is manifest as high blood pressure, stroke, heart attack and abnormalities of heart rhythm, or cardiac arrhythmias. A western diet, ie. one high in animal fat, or saturated fats, may be to blame. Human epidemiological studies have shown that consumption of a diet high in saturated fats is correlated with a propensity to arrhythmias while a diet high in polyunsaturated fatty acids (PUFAs) can confer protection from coronary heart disease and cardiac arrhythmias. The mechanisms underlying these effects are not fully understood. The contraction of the heart depends on changes in calcium inside the individual muscle cells. Abnormalities of the way calcium is handled in the cells leads to abnormalities of contraction and to a certain types of arrhythmia. Over the last 5 to 10 years, technological developments have enabled us to examine changes in calcium in living heart cells at microscopic level. It is possible to fill individual living cells with a fluorescent dye which changes either the magnitude or the wavelength of its fluorescence according to the ambient calcium concentration. Cells filled with these dyes are examined with a laser scanning confocal microscope, in which a very tightly focussed laser beam excites the dye and the resulting fluorescence is gathered by a computer controlled image analysis system. In this way we can measure the calcium concentration within the cells with a spatial resolution of about 1-1000 of a millimetre, and a time resolution of about 1-100 of a second. Using these techniques, we have found that supplementing the diet of rats with either PUFAs or saturated fats produces a dramatic change in the way that calcium is stored and released in their heart cells. This effect of dietary fats has not been reported before, and it may represent an important clue as to how these substances protect against many cardiac arrhythmias.Read moreRead less
Clinical trials and experimental investigations have demonstrated that a diet rich in fish oil, containing high levels of omega 3 fatty acids, provides protection against arrhythmias and sudden cardiac death associated with heart failure. Surprisingly little is known about how these dietary omega 3 lipids alter the electrical and mechanical function of cardiac muscle cells when incorporated into the membrane of these cells. The goal of this study is to examine how experimental omega 3 diet treat ....Clinical trials and experimental investigations have demonstrated that a diet rich in fish oil, containing high levels of omega 3 fatty acids, provides protection against arrhythmias and sudden cardiac death associated with heart failure. Surprisingly little is known about how these dietary omega 3 lipids alter the electrical and mechanical function of cardiac muscle cells when incorporated into the membrane of these cells. The goal of this study is to examine how experimental omega 3 diet treatment can modify the heart muscle cell structure and function. In particular we will determine which cellular mechanisms may be important in conferring selective benefit of dietary intervention on pre-failing heart function. For this study we will use mice which exhibit signs of heart failure induced by hormone overproduction (angiotensin II) and by elevation of blood pressure (by surgical constriction). Mice will be fed omega-3 and omega-6 diets and experiments to investigate cardiac muscle cell structure and function will be carried out using a variety of electrical recording, microscopic and molecular biology techniques. Diet-induced changes in the capacity of the heart cells to regulate calcium will be investigated using cells loaded with fluroescent indicators. Single cell electrical recording techniques (patch clamp) will also be used in combination with ECG measurement to evaluate how arrhythmic activity arising from electrically and mechanically unstable cells can be suppressed by omega-3 diet intervention. Finally we will take the first step towards validating the rodent experimental findings in a clinical setting with measurements of calcium transporters and channel expression in human specimens from cardiac surgery patients.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102784
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Water-swellable rubber with nanoparticle-enabled super capacity as smart water-leakage sealant. A novel water-swellable rubber (WSR) sealant with continuous hydrophobic phase and isolated hydrophilic phase is developed for stopping water leakage from gaps and cracks. Nanoparticle-enabled blocks and network channels in rubber matrix effectively improve the integrity and capability of WSR as smart water-leakage sealants in various applications.
Effect of processing on microstructure of 'Biocrete' organo-mortar. 'Biocrete' is a novel organo-mortar whose composition differs substantially from conventional Portland cement based polymer mortars. It is a relatively new product with significant commercial potential because of its acid resistance and ease of application. However, the microstructure of this material is extremely complex and not well understood nor is the way the microstructure develops during the processing and application of ....Effect of processing on microstructure of 'Biocrete' organo-mortar. 'Biocrete' is a novel organo-mortar whose composition differs substantially from conventional Portland cement based polymer mortars. It is a relatively new product with significant commercial potential because of its acid resistance and ease of application. However, the microstructure of this material is extremely complex and not well understood nor is the way the microstructure develops during the processing and application of the material known. This project will use advanced materials characterisation methods to elucidate the microstructure and to quantify the effects of processing parameters on the microstructure. Such information is critical for further formulation and application development in important areas such as sewer relining.Read moreRead less