Safe Koori Kids: Community Based Approaches To Indigenous Injury Prevention
Funder
National Health and Medical Research Council
Funding Amount
$671,905.00
Summary
The study will involve the development of an intervention targeting Indigenous children, schools and families and schools in urban environments. Specifically, over a three year period, the proposed research aims to: explore the incidence and impact of intentional and unintentional injury in selected urban Indigenous communities in NSW and identify factors contributing to positive and negative consequences relating to injury; develop and evaluate initiatives in Indigenous communities aimed at inc ....The study will involve the development of an intervention targeting Indigenous children, schools and families and schools in urban environments. Specifically, over a three year period, the proposed research aims to: explore the incidence and impact of intentional and unintentional injury in selected urban Indigenous communities in NSW and identify factors contributing to positive and negative consequences relating to injury; develop and evaluate initiatives in Indigenous communities aimed at increasing resiliency in at-risk children, youth and families; and make recommendations for changes to policy and practice across a range of government portfolios and non-government organisations. Injury, which has received almost no research attention among Indigenous populations, is the leading cause of death, illness and disability for young Australians with the burden of injury for Indigenous Australians significantly higher than for the non-Indigenous population. Indigenous children and youth are over-represented in both intentional (eg. suicide, domestic violence and abuse, assaults and self-harm) and unintentional (eg. burns, road injury, falls and drowning) injury statistics. The complexity of injury to Indigenous people and its 'downstream' impact on families and communities has been documented in recent studies and reports. Although Indigenous children and youth are particularly vulnerable to the impact of injury, there have been few studies that have documented the incidence and impact of injury on Indigenous children or which have offered sustainable and culturally acceptable solutions to the problem of injury. The proposed research focuses on the development of effective, sustainable and culturally acceptable interventions for Indigenous children and youth based on an Indigenous perspective.Read moreRead less
Risk Factors For Serious Farm-work Related Injury Among Adult Males
Funder
National Health and Medical Research Council
Funding Amount
$665,930.00
Summary
This study addresses occupational injury among male adult farm workers. The health and safety performance of agricultural industries is among the worst in Australia. A recently published study of work-related fatalities from 1989 to 1992 found that rural industries ranked third, with a fatality rate 3-4 times that for all industries. The rural industries accounted for 80 deaths annually. Best estimates place the cost of farm injury between $0.5 and $1.29 billion per year. This study is designed ....This study addresses occupational injury among male adult farm workers. The health and safety performance of agricultural industries is among the worst in Australia. A recently published study of work-related fatalities from 1989 to 1992 found that rural industries ranked third, with a fatality rate 3-4 times that for all industries. The rural industries accounted for 80 deaths annually. Best estimates place the cost of farm injury between $0.5 and $1.29 billion per year. This study is designed to contribute to farm injury prevention by: (1) identifying factors associated with a higher risk of serious injury among adult farm workers and (2) determining the proportions of the farm workforce who are exposed to various injury risks. The study will recruit 300 seriously injured or killed farm workers from regional Victoria and collect information about themselves, their working life and the property on which they work. This information will be compared with 600 randomly selected farm workers who are not seriously injured to determine which personal, work and environmental factors place farm workers at higher risk of injury. The study will lead to the development of new or more refined prevention strategies and programs. A study of this kind has not been conducted before in Australia and would contribute to a continuing scientific basis for selection of interventions for farm injury and targeting of prevention programs, at a time of increasing momentum in agricultural health and safety.Read moreRead less
The Neural Reaction To Injury: Clues To The Cause And Prevention Of Acquired Brain Damage And Alzheimer's Disease.
Funder
National Health and Medical Research Council
Funding Amount
$390,326.00
Summary
The cellular mechanism underlying neuronal degeneration following head trauma and Alzheimer?s disease is not known and represents the major impediment to developing therapeutic strategies to protect nerve cells. This grant application will utilise a variety of modern research methods to determine the key changes in the brain that are associated with the response of nerve cells to physical trauma. These include not only the structural alterations that immediately follow such injury, but the compl ....The cellular mechanism underlying neuronal degeneration following head trauma and Alzheimer?s disease is not known and represents the major impediment to developing therapeutic strategies to protect nerve cells. This grant application will utilise a variety of modern research methods to determine the key changes in the brain that are associated with the response of nerve cells to physical trauma. These include not only the structural alterations that immediately follow such injury, but the complex cellular and gene expression changes that determine the ultimate fate of the cell. Both acquired brain injury and degenerative conditions such as Alzheimer?s disease represent an enormous health, social and economic burden. Furthermore, with predictions that Alzheimer?s disease will increase by 3-4 times by the middle of the next century due to the Oaging? of the population, it is becoming even more crucial to establish effective therapeutic interventions. The animal models investigated in this project can be used to unravel the crucial neuronal alterations associated with head trauma and the early stages of Alzheimer?s disease and, more importantly, may be the key to discovering novel strategies to prevent neuronal degeneration in these conditions.Read moreRead less
Characterisation Of Substance P Antagonists As A Novel Therapeutic Intervention For Use In Traumatic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$241,650.00
Summary
Traumatic brain injury (TBI) is responsible for more deaths in Australians under 45 years of age than any other cause. The economic and social cost of head injury to the community is enormous with billions of dollars spent each year on the management and rehabilitation of trauma patients. Despite the enormity of this public health problem, no effective treatment currently exists. A number of studies have demonstrated that much of the morbidity following TBI is associated with the development of ....Traumatic brain injury (TBI) is responsible for more deaths in Australians under 45 years of age than any other cause. The economic and social cost of head injury to the community is enormous with billions of dollars spent each year on the management and rehabilitation of trauma patients. Despite the enormity of this public health problem, no effective treatment currently exists. A number of studies have demonstrated that much of the morbidity following TBI is associated with the development of a secondary injury process that occurs between hours to days after the insult. This delayed progression of injury suggests that appropriate pharmacologic intervention can prevent, or at least attenuate, this secondary injury process with a resultant improvement in outcome. Over the past 15 years, a number of groups, including ours, have been investigating the secondary mechanisms associated with the development of functional deficits after TBI. Our previous studies have demonstrated that decline in brain free magnesium is associated with functional deficits after experimental brain injury, and that magnesium administration after injury can improve outcome. Magnesium is now on clinical trial as a pharmacologic intervention. Recent studies have suggested that magnesium decline facilitates neurogenic inflammation, which has been associated with oedema formation, oxidative damage and cell death. Although a number of neuropeptides have been implicated in this process, it is thought that substance P release is closely associated with these pathophysiological processes. Therefore, inhibiting neuropeptide release, or inhibiting substance P binding, may offer a novel therapeutic approach for the attenuation of oedema and development of neurologic deficits after TBI. This proposal will use a combined biochemical, pharmacologic and behavioural approach to characterise the role of neuropeptides in brain trauma, and attempt to develop a novel therapy for use in clinical trauma.Read moreRead less
Neuroprotection By Ndfip1 In Brain Injury - Identifying Targets And Understanding Mechanisms
Funder
National Health and Medical Research Council
Funding Amount
$836,225.00
Summary
Brain injury from trauma and motor vehicle accidents is a serious health issue, affecting approximately 30,000 Australians per year. About 10% of the victims suffer serious long term consequences, including mental, physical and behavioural impairment. We have discovered a new brain protein capable of preventing neurons from dying following injury. This grant will improve our understanding of how this protein works, and provide a scientific foundation for devising therapies.
Interactions Between Injured Neurons, Astrocytes And Metallothionein
Funder
National Health and Medical Research Council
Funding Amount
$478,067.00
Summary
We have found that the protein, metallothionein, which protects the brain after injury or during neurodegenerative disease acts in a more complex way than previously thought, including a direct action on injured neurons as well as on the originating cell, astrocytes. Elucidating each component of metallothionein action will help us understand how cells interact in the brain after injury, and excitingly, offers an opportunity to develop an enhanced therapeutic strategy based on this protein.
A Prospective Study Of Concussion In Children And Adolescents: Diagnosis, Recovery And Risk Factors For Poor Outcome.
Funder
National Health and Medical Research Council
Funding Amount
$277,000.00
Summary
Concussion is one of the most common neurological injuries and represents a significant public health issue in Australia. The most common consequences of concussive injuries are reduced attention, slowed response speeds and memory impairment. These cognitive processes are critical for performing common day-to-day activities in childhood and adolescence (e.g. acquiring new knowledge and skills, attending to school work). Approximately 20% of concussive injuries occur during participation in organ ....Concussion is one of the most common neurological injuries and represents a significant public health issue in Australia. The most common consequences of concussive injuries are reduced attention, slowed response speeds and memory impairment. These cognitive processes are critical for performing common day-to-day activities in childhood and adolescence (e.g. acquiring new knowledge and skills, attending to school work). Approximately 20% of concussive injuries occur during participation in organised sport. In adult populations, there are now evidence-based guidelines for the diagnosis and management of concussion in sport. Few well-controlled studies exist to identify the frequency and outcome of such injuries in child and adolescent populations, and there are currently no guidelines for diagnosis and management of concussion in children. Further, the academic and social consequence of concussion for the child remains unknown. This study will investigate the cognitive and behavioural outcomes of concussion in young children and adolescents and will use this information to modify and validate currently available adult concussion diagnosis and management paradigms for application with this population. This study will also investigate risk factors for poor outcome following concussion in children and adolescents, and provide age-appropriate data for use in the medical, behavioural and educational management of concussed children and adolescents. A total of 3000 children aged between 10 and 18 years will be recruited to participate in this study. All participants will undergo a baseline evaluation consisting of memory and attention tests, a behavioural rating scale, and measures of educational ability. Participants parents will also provide general health and demographic information. Children who are concussed during the year will be re-assessed within 48 hours of injury and again at 5 days, 10 days and 30 days post-injury to track recovery.Read moreRead less
How Does The LRP Receptor Megalin Promote Regenerative Neuronal Growth?
Funder
National Health and Medical Research Council
Funding Amount
$408,739.00
Summary
Promoting the regenerative growth of neurons to allow recovery from traumatic brain injury or Alzheimer's disease is a major goal of neuroscientists. This project continues the Chief Investigators' work in which they have discovered the regenerative potential of a protein and focuses on how this protein interacts with a key neuronal receptor, megalin, which appears to drive the regenerative process. This work will identify new targets for therapies for a range of nervous system disorders.
Cohort Study Of Risk Factors For Young Driver Injuries
Funder
National Health and Medical Research Council
Funding Amount
$689,830.00
Summary
Injuries impose a substantial burden on young people, both in Australia and internationally. In 1998, 70% of all deaths among young men, and 57% of deaths among young women, aged 15-24 years in Australia were due to injuries. The single largest cause of injury-related fatalities, hospital admissions and emergency department presentations among this age group is transport-related incidents. Technological advances in motor vehicle engineering and road design, and the implementation of various road ....Injuries impose a substantial burden on young people, both in Australia and internationally. In 1998, 70% of all deaths among young men, and 57% of deaths among young women, aged 15-24 years in Australia were due to injuries. The single largest cause of injury-related fatalities, hospital admissions and emergency department presentations among this age group is transport-related incidents. Technological advances in motor vehicle engineering and road design, and the implementation of various road safety measures, such as random breath testing, have led to an overall decline in the incidence of motor vehicle-related injuries in Australia in the past three decades. However, young people still have substantially higher rates of motor vehicle-related mortality than older people. This suggests that if the burden of injuries among young drivers is to be reduced to levels that are at least as comparable with those in other age-groups, then the identification of factors that are specifically associated with an increased risk of motor vehicle injury among young people, must be a priority. The current study aims to determine the role of several postulated risk factors in the incidence of young driver injuries. The specific risk factors to be examined include pre-licence road and driving exposure-experience; type, quality and quantity of driver training; and road risk perceptions and engagement in sensation seeking behaviours. The study also seeks to determine whether factors associated with increased risk of driver injury are the same for different socio-economic groups and for different ethnic and cultural groups. Information obtained in this study should provide reliable evidence about causal factors for motor vehicle crash injury among young drivers. Such information should be useful to licensing and road safety professionals, in the design of practical road safety strategies aimed at reducing the burden of young driver injuries.Read moreRead less