The Australian Research Data Commons (ARDC) invites you to participate in a short survey about your
interaction with the ARDC and use of our national research infrastructure and services. The survey will take
approximately 5 minutes and is anonymous. It’s open to anyone who uses our digital research infrastructure
services including Reasearch Link Australia.
We will use the information you provide to improve the national research infrastructure and services we
deliver and to report on user satisfaction to the Australian Government’s National Collaborative Research
Infrastructure Strategy (NCRIS) program.
Please take a few minutes to provide your input. The survey closes COB Friday 29 May 2026.
Complete the 5 min survey now by clicking on the link below.
Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest: A Phase III Multi-Centre Randomised Controlled Trial (The TAME Cardiac Arrest Trial)
Funder
National Health and Medical Research Council
Funding Amount
$2,069,878.00
Summary
The TAME Cardiac Arrest trial will study the ability of higher carbon dioxide (CO2) levels to reduce brain damage, comparing giving patients ‘normal’ to ‘slightly higher than normal’ blood CO2 levels and assessing their ability to return to normal life-tasks. It will be the largest trial ever conducted in heart attack patients in the ICU. This therapy is cost free and, if shown to be effective, will improve thousands of Australian lives, transform clinical practice, and yield major savings.
Breathing In Chronic Heart Failure: Is There Novel Pulmonary Compensation?
Funder
National Health and Medical Research Council
Funding Amount
$312,021.00
Summary
Chronic heart failure (CHF) is a growing modern epidemic and therefore a costly health burden in Australia. Not only is it associated with a high mortality rate, symptoms of CHF are a major cause of patient suffering. Shortness of breath and exercise intolerance are both indicators of a link between CHF and lung function. There are a number of different ways in which CHF may be impacting on breathing and in this project we will be utilising an animal model to examine some of them. Firstly, the l ....Chronic heart failure (CHF) is a growing modern epidemic and therefore a costly health burden in Australia. Not only is it associated with a high mortality rate, symptoms of CHF are a major cause of patient suffering. Shortness of breath and exercise intolerance are both indicators of a link between CHF and lung function. There are a number of different ways in which CHF may be impacting on breathing and in this project we will be utilising an animal model to examine some of them. Firstly, the lung secretes a substance called surfactant which assists in normal breathing by decreasing surface tension in the lung. Previous studies in our laboratory have suggested an increase in surfactant production during CHF. In this project we will further examine this process to see if increased surfactant can aid breathing by decreasing surface tension during CHF. Secondly, we will examine the contribution made by the chest wall, increased heart size, lung volume and blood pressure during CHF on breathing. Thirdly, one of the problems thought to inhibit breathing in CHF patients is an increase in fluid in the lungs. The final stage of this project will examine the trasport of fluid into and out of the lung during CHF. This project will not only increase our understanding of the processes affecting breathing in response to CHF, but will also provide information for the development of potential therapeutic targets.Read moreRead less
The RINSE Trial: The Rapid Infusion Of Cold Normal SalinE By Paramedics During CPR
Funder
National Health and Medical Research Council
Funding Amount
$708,241.00
Summary
Sudden cardiac arrest is a common event in the community. Therapeutic hypothermia decreases the brain injury caused by the cardiac arrest and is currently used in the hospital after successful resuscitation. However, there may be better outcomes if the brain is cooled by paramedics during resuscitation. We will compare survival rates for those patients cooled early by paramedics using an infusion of ice-saline during cardiac arrest with those patients who are later cooled by the hospital.
Performance And Delivery Of Cardiovascular Health Services
Funder
National Health and Medical Research Council
Funding Amount
$389,860.00
Summary
Heart disease is an important cause of death and disability. The treatments received by patients hospitalised with common heart conditions can vary considerably. At present, there are no systematic methods in place to routinely assess the quality of care or patient outcomes following hospitalisation. This proposal keeps developing quality indicators to measure care experienced by patients admitted following a heart attack or those with heart failure as well for those undergoing common cardiac pr ....Heart disease is an important cause of death and disability. The treatments received by patients hospitalised with common heart conditions can vary considerably. At present, there are no systematic methods in place to routinely assess the quality of care or patient outcomes following hospitalisation. This proposal keeps developing quality indicators to measure care experienced by patients admitted following a heart attack or those with heart failure as well for those undergoing common cardiac procedures.Read moreRead less
Value-Based Healthcare In Elective Coronary Stenting
Funder
National Health and Medical Research Council
Funding Amount
$1,236,881.00
Summary
Coronary stents are wire mesh tubes inserted into cholesterol blockages in heart blood vessels (arteries) thus improving coronary blood flow and alleviating chest pain. Although life saving in acute heart attacks, their value is limited in stable patients and may be associated with severe complications. In partnership with the health department, this project will evaluate how many patients continue to experience chest pain after elective coronary stenting so that can be used more effectively.
Quadruple UltrA-low-dose TReamenT For HypErTension - QUARTET
Funder
National Health and Medical Research Council
Funding Amount
$1,242,865.00
Summary
High blood pressure is common and a major cause of heart disease and stroke. While many people with hypertension are on some treatment, in over half blood pressure targets are not reached and their high blood pressure is hence uncontrolled. In this research we investigate whether an approach that combines 4 types of blood pressure lowering medications at quarter doses into one pill, may be a more effective way of controlling blood pressure and doing this with few side effects.
Translating Science Into Treatment For Ischemic Stroke
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
My team has pioneered research in Australia that has advanced knowledge in the delivery of safer and more effective stroke therapies. I have developed software for the automated processing of multimodal CT imaging to better select patients for stroke therapies. In order to move this cutting-edge imaging technology into routine clinical practice several processes will occur: Implementation, validation and demonstration of patient benefits, and cost effectiveness of CT imaging selection in routine
Improving The Prevention, Treatment And Management Of Cardiovascular & Chronic Disease In The Community
Funder
National Health and Medical Research Council
Funding Amount
$774,540.00
Summary
The identification, prevention and management of cardiovascular and chronic disease risk factors and understanding impact on clinical outcomes is fundamental to improving health and well-being. The program of work encapsulated in this application utilises modern epidemiological research methods involving large scale clinical trials, registries and epidemiological modelling to advance our understanding and provide new directions for cardiovascular disease prevention and management.
An Integrated General Practice And Pharmacy-based Intervention To Promote The Prescription And Use Of Appropriate Preventive Medications Among Individuals At High Cardiovascular Risk.
Funder
National Health and Medical Research Council
Funding Amount
$2,380,071.00
Summary
We will conduct a randomised controlled trial that combines three methods to reduce risk factors and improve outcomes for people with cardiovascular disease (CVD). The methods include administration of a polypill, a GP-focused point-of-care intervention, and a pharmacy-led intervention to improve commencement and persistence with taking medications. We expect that integrating these three approaches will lead to large reductions in CVD risk factor levels for participants.