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  • Funded Activity

    Assessing The Benefit Of Low Dose Aspirin In The Prevention Of Severe Sepsis.

    Funder
    National Health and Medical Research Council
    Funding Amount
    $391,880.00
    Summary
    Recent discoveries suggest that low doses of aspirin may save lives in patients with infection by limiting its severity. We will conduct a large-scale primary prevention study using daily low-dose aspirin to explore whether this widely used drug can safely prevent severe infection. This study is made possible by collaborative involvement in an existing Australian and USA funded study called ASPREE. Finding a treatment that helps prevent severe effects and outcomes of infection would be a major h .... Recent discoveries suggest that low doses of aspirin may save lives in patients with infection by limiting its severity. We will conduct a large-scale primary prevention study using daily low-dose aspirin to explore whether this widely used drug can safely prevent severe infection. This study is made possible by collaborative involvement in an existing Australian and USA funded study called ASPREE. Finding a treatment that helps prevent severe effects and outcomes of infection would be a major health advance.
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    Funded Activity

    Re-EValuating The Inhibition Of Stress Erosions (REVISE): Gastrointestinal Bleeding Prophylaxis In ICU

    Funder
    National Health and Medical Research Council
    Funding Amount
    $2,955,164.00
    Summary
    Around 50,000 patients in Australian Intensive Care Units receive a drug called pantoprazole each year with the aim of preventing bleeding from the gut. Recent research suggests this practice is ineffective and may harm patients by increasing their risk of serious infections. We will perform a definitive study to determine whether the widespread use of pantoprazole is beneficial or harmful.
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    Funded Activity

    Treatment Of Invasively Ventilated Adults With Early Activity And Mobilisation

    Funder
    National Health and Medical Research Council
    Funding Amount
    $1,467,137.00
    Summary
    The sickest patients in intensive care units (ICUs) receive prolonged, invasive support for their breathing. This is currently managed with complete bed rest, and results in severe muscle weakness, increased duration of hospital stay and poor recovery. We have found that early activity and mobilisation during invasive breathing support is safe and may improve survival and recovery. We will test early activity and mobilisation in a large randomised controlled trial of 750 ICU patients.
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    Funded Activity

    A Cluster Randomised Controlled Trial Of Selective Decontamination Of The Digestive Tract In Critically Ill Patients

    Funder
    National Health and Medical Research Council
    Funding Amount
    $4,113,393.00
    Summary
    Sepsis is the most common cause of death in intensive care patients. Selective Decontamination of the Digestive Tract (SDD) is a treatment to reduce the risk of infection and improve survival for these patients. Many trials suggest SDD works but there has not been widespread uptake due to concerns that SDD will increase antibiotic resistance.rates. This trial will provide a definitive answer. If SDD reduces mortality without increasing antibiotic resistance, the study will have a global impact.
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    Funded Activity

    Neuroprotective Role Of Sulphate Among Preterm Babies (SuPreme Study)

    Funder
    National Health and Medical Research Council
    Funding Amount
    $749,338.00
    Summary
    Magnesium sulphate administered to mothers shortly before preterm birth, reduces the risk of cerebral palsy. The mechanism of its neuroprotective effect is unknown, and our studies suggest sulphate is the protective element. Preterm babies rapidly become sulphate deficient, and magnesium sulphate mitigates this deficiency in most infants. In this study we will investigate whether low blood sulphate levels at 1 week of age correlate with cerebral palsy.
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    Funded Activity

    Organizational Change And Treatment Of Depression And Dementia In Aged Care Facilities

    Funder
    National Health and Medical Research Council
    Funding Amount
    $567,052.00
    Summary
    Mental health disorders are common in aged care settings. However, these problems are not well managed. This situation results in distress for residents and family members, as well as high levels of burnout and turnover among staff. This project will address the organizational barriers with the aim of better managing and treating depression and behavioural problems associated with dementia.
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    Funded Activity

    Telehealth In Residential Aged Care Facilities: Improving Access To Specialist Care

    Funder
    National Health and Medical Research Council
    Funding Amount
    $972,606.00
    Summary
    People in long term residential care have complex and chronic care issues. The staff may be able to provide more focused care if they have the support of specialists for advice on the care of residents. This project considers the value of a geriatric specialist assessment for all new residents via video conferencing, directly to the residential care facility. This will be supplemented by access to a wide range of other specialists coordinated through a telehealth service model on an "as needs" b .... People in long term residential care have complex and chronic care issues. The staff may be able to provide more focused care if they have the support of specialists for advice on the care of residents. This project considers the value of a geriatric specialist assessment for all new residents via video conferencing, directly to the residential care facility. This will be supplemented by access to a wide range of other specialists coordinated through a telehealth service model on an "as needs" basis.
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    Funded Activity

    A Sequential Multiple Assignment Randomised Trial (SMART) Of Nursing Interventions To Reduce Pain Associated With Chemotherapy Induced Peripheral Neuropathy

    Funder
    National Health and Medical Research Council
    Funding Amount
    $713,418.00
    Summary
    Modern chemotherapy treatments can result in damage to the peripheral nerves, resulting in a condition called peripheral neuropathy. This condition is characterised by a range of sensory and functional changes that can cause pain and reduced ability to perform daily activities. This project will test various non-pharmacological pain management measures to determine if they are effective in improving the quality of life of patients who experience this problem.
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    Funded Activity

    Predictors Of Home Telehealth Adoption In The Aging Population: Consumer Perspectives

    Funder
    National Health and Medical Research Council
    Funding Amount
    $325,255.00
    Summary
    Care of the aging population will place a huge burden on the Australian healthcare system. It is now possible for health services to be provided across the Internet (telehealth) into the aged person’s home. The problem is there has been a slow uptake of telehealth services. What is needed is a clear understanding of aged consumers’ perspectives on telehealth and why they would engage in such services. These findings will assist in planning health care services for the aged into the future.
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    Funded Activity

    Investigating The Relationship Between Depression, Anxiety And Nausea And Vomiting During Pregnancy: Causation Or Shared Liability?

    Funder
    National Health and Medical Research Council
    Funding Amount
    $600,874.00
    Summary
    Recent studies showing women who experience severe Nausea and vomiting during pregnancy (NVP) have higher rates of Anxiety and Depression prior to pregnancy have revived earlier hypotheses that NVP may have a psychogenic component. We hypothesize that Anxiety and Depression do not play a causal role in NVP but rather, the relationship is due to shared risk from genetic effects that influence both traits. We will test this hypothesis using genetic and epidemiological approaches.
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