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Actions Of The Polyphenol Epigallocatechin 3-gallate On Insulin Sensitivity
Funder
National Health and Medical Research Council
Funding Amount
$409,746.00
Summary
This project will determine whether the bioactive compound in green tea (called EGCG) can reduce insulin resistance by enhancing the ability of insulin to open very small blood vessels (called capillaries) in muscle. Opening more capillaries will help glucose to be stored in muscle, thus alleviating insulin resistance. Findings from these studies may have important impact on the management of insulin resistance and type 2 diabetes.
Novel Therapeutic Interventions To Increase Blood Flow To Skeletal Muscle
Funder
National Health and Medical Research Council
Funding Amount
$360,750.00
Summary
Over the past decade it has become clear that the cytokine interleukin (IL)-6 is produced in and released from tissues such as fat and muscle to mediate metabolic processes. In this respect, it acts in a hormone like manner. During this period it has also become apparent that the hormone insulin increases blood flow to skeletal muscle. There is emerging evidence that IL-6 plays a role, not only in metabolic and signalling processes within skeletal muscle, but also in blood flow. This project wil ....Over the past decade it has become clear that the cytokine interleukin (IL)-6 is produced in and released from tissues such as fat and muscle to mediate metabolic processes. In this respect, it acts in a hormone like manner. During this period it has also become apparent that the hormone insulin increases blood flow to skeletal muscle. There is emerging evidence that IL-6 plays a role, not only in metabolic and signalling processes within skeletal muscle, but also in blood flow. This project will determine whether the cytokine IL-6 is a viable therapeutic target in the treatment of blood flow disorders in patients with type 2 diabetes. This has major ramifications since type 2 diabetes has reached pandemic levels in Australia and is estimated to cost the community approximately 800 million dollars per year.Read moreRead less
Early Origins, Progression And Aetiology Of Obesity, Metabolic Syndrome And Diabetes: A 30 Years Follow-up Study
Funder
National Health and Medical Research Council
Funding Amount
$1,194,979.00
Summary
This research proposal aims to use the unique existing Mater University Study of Pregnancy (MUSP) and its offspring data and conduct a 30-year follow-up of MUSP children to investigate the early origins, progression and causal pathways of obesity, metabolic syndrome and diabetes for young Australian. Findings of this study will extend our understanding of the factors driving these health problems with the ultimate aim of being able to reverse the obesity epidemic and improve public health.
Childhood Precursors Of Adult Cardiovascular Disease, Obesity And Diabetes- 16 Year Follow Up Of A Longitudinal Cohort
Funder
National Health and Medical Research Council
Funding Amount
$835,631.00
Summary
There is a world wide 'epidemic' of obesity and diabetes with rates tripling in young adults in the last twenty years. This is likely to lead to an upsurge in heart attack and stroke and to reverse many of the gains seen in this area in Australia. This project aims to study the childhood and antenatal precursors for the risk of adult obesity, diabetes, heart disease and stroke. The study involves The Perth longitudinal childrens 'Raine' cohort, a unique group of just under 3000 children, first m ....There is a world wide 'epidemic' of obesity and diabetes with rates tripling in young adults in the last twenty years. This is likely to lead to an upsurge in heart attack and stroke and to reverse many of the gains seen in this area in Australia. This project aims to study the childhood and antenatal precursors for the risk of adult obesity, diabetes, heart disease and stroke. The study involves The Perth longitudinal childrens 'Raine' cohort, a unique group of just under 3000 children, first monitored in the womb before mid pregnancy and then repeatedly through to the age of 13 years. Every 2 to 3 years the study children have been carefully assessed for changes in fatness, blood pressure and more recently, nutrition, physical activity and fitness, blood cholesterol and tendency to diabetes. Families have also been carefully monitored for a range of social characteristics and mental health. We already have evidence that about a fifth of the children at age 8 are particularly at risk of obesity, diabetes and cholesterol problems and high blood pressure. We now plan to study the children after puberty at age 16, when they will be adopting a range of more adult behaviours which may profoundly affect these risks. This study will provide comprehensive information on the children from before birth to adolescence and help pinpoint ways in which growth in the womb, and subsequent childhood behaviour interacts with influences of family, social factors, environment and mental health to affect long term risk of obesity, premature diabetes or heart disease. The study will also provide a basis for future examination of the links between genes, environment and health.Read moreRead less
JDRF/NHMRC Diabetes Complications Centre Of Research Excellence
Funder
National Health and Medical Research Council
Funding Amount
$2,607,291.00
Summary
Despite intensive intervention some individuals with type 1 diabetes develop complications. There remains an urgent need for means to identify patients at risk of complications and new targets and therapies for preventing, arresting, treating and reversing them. The primary objective of the Diabetes Complications Centre of Research Excellence (DC-CRE) is to translate novel experimental findings into preventive/treatment strategies for the management of diabetes and its complications.
Identifying The Epigenomic Fingerprint Of Coronary Heart Disease In Chinese Adults With Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$596,663.00
Summary
Once people get diabetes, even good glucose control may be insufficient to prevent its complications. Diabetes results in molecular imprinting contributing to an increased risk of heart disease. We believe it is possible to identify this imprinted risk by a sophisticated analysis of a standard blood sample. Validating this hypothesis will lead to new biomarkers to identify individuals at increased risk of heart attacks as well as new strategies for the prevention and treatment of heart disease.
Contribution Of The Peri-renal Environment To Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$335,008.00
Summary
This proposal will investigate the peri-renal adipose tissue phenotype and if factors derived from this local adipose tissue depot can influence kidney function
Reversing Oxidative Inhibition Of The Na-K Pump By Beta3 Adrenergic Agonists: Implications For Heart Failure Therapy
Funder
National Health and Medical Research Council
Funding Amount
$533,541.00
Summary
Heart failure is a debilitating condition characterised by a decreased heart pump function. Raised Na+ levels and increased oxidative stress in cardiac cells are important in its causation. While traditional antioxidants are not useful in treatment, we have found that a group of drugs designed to induce weight loss can reverse oxidative inhibition of the mechanism that pumps Na+ out of heart cells. The effect of these drugs on the Na+ pumping mechanism and heart failure will be examined.