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This research proposal will identify changes in liver-secreted proteins during the development of fatty liver, and in the transition from fatty liver to the more advanced form of liver disease, non-alcoholic steatohepatitis (NASH). Understanding the differences in protein secretion between NASH patients and patients with normal/fatty liver will provide the opportunity to identify disease biomarkers that could be determined from a blood sample. This will provide a major shift in clinical care.
Control Of Musculoskeletal Function And Glucose Metabolism By Androgens In Men
Funder
National Health and Medical Research Council
Funding Amount
$245,031.00
Summary
Male sex hormone or androgen deficiency (AD) is a common, but under-diagnosed condition. AD decreases general well being and contributes to muscle weakness, bone fragility and weight gain. By using cutting edge imaging and molecular technologies, we will help to explain the underlying mechanisms of how AD leads to these negative effects. This should ultimately lead to reduction of adverse outcomes of AD, which include fractures and cardiovascular events.
Mitochondrial Energy Metabolism And Insulin Action
Funder
National Health and Medical Research Council
Funding Amount
$380,558.00
Summary
Obesity and type 2 diabetes are two major health conditions associated with abnormal energy metabolism. In this proposal I will investigate the role of important metabolic proteins in regulating energy expenditure and insulin action in skeletal muscle and adipose tissue, two crucial tissues for whole-body energy metabolism. These studies will provide critical insight into the factors leading to obesity and type 2 diabetes and will assist in identifying possible therapeutic targets.
Restoration Of Diabetes Associated Cognitive Deficits Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$430,998.00
Summary
Diabetes is known to increase the risk of dementia. Although the mechanisms are currently unknown, a recently emerging body of evidence suggest that damaged blood vessels of the brain may be central to onset and progress of cognitive dysfunction. Consistently, the dysfunction of brain blood vessels is often observed in the brain of diabetes subjects. Therefore, this project will investigate whether the amelioration of disrupted brain blood vessels restores the cognitive function in diabetes.
An Integrated Approach To Identify The Molecular Mechanisms Contributing To The Pathogenesis Of Insulin Resistance: Targeting The Liver And Skeletal Muscle
Funder
National Health and Medical Research Council
Funding Amount
$415,218.00
Summary
The inability of muscle and liver to utilise sugar from the blood is a major problem that contributes to the development of obesity and diabetes. How these problems occur is unknown. The goal of my research is to identify what causes the muscle and liver problem, and whether fixing these problems will reduce obesity and diabetes. Since the number of people with obesity and diabetes is predicted to double over the next decade, we need to understand the cause of these diseases.
The Prevention And Optimal Treatment Of Type II Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$227,332.00
Summary
Lifestyle related metabolic disease including obesity and diabetes, represent a disease continuum and present an increasing public health challenge. This research focuses on mechanisms underpinning lifestyle diseases and on prevention and treatment covering the spectrum from health related behaviours (barriers to change and behavioural modification), to mechanisms of action of exercise-diet and medications, to public health interventions to improve prevention and treatment of lifestyle diseases.