The Transgenerational Epigenetic Inheritance Of Parental Obesity
Funder
National Health and Medical Research Council
Funding Amount
$362,431.00
Summary
The current global epidemic of obesity and diabetes has partly been fuelled by the propagation of these diseases from parent to child across multiple generations. Successful completion of this study will provide hard evidence that there is an inborn but non-genetic component to the risk of obesity and provide insights into the mechanisms by which that risk is created and transmitted from both the mother and the father to the child.
The Role Of Exercise Intervention In The Management And Prevention Of Insulin Resistance In Reproductive Aged Women
Funder
National Health and Medical Research Council
Funding Amount
$57,342.00
Summary
Research will focus on the use of exercise intervention in two insulin resistant groups of reproductive aged women including women at high risk of gestational diabetes and with polycystic ovary syndrome. Insulin resistance, if left unmanaged has long term health implications and information gained from the research would provide valuable information on the efficacy of exercise intervention and its role in treatment-prevention of complications of these common conditions.
Intermittent Fasting Versus Daily Energy Restriction For Improved Human Health
Funder
National Health and Medical Research Council
Funding Amount
$987,048.00
Summary
Intermittent fasting (IF) is a nutritional strategy consisting of a period where food is freely available, followed by periods where food is withheld. This proposal will build on our past findings and assess the long term effects of IF on metabolic health, and weight in individuals with pre-diabetes. This study will have significant implications for informing current dietary practice, and provide a legitimate strategy to managing the metabolic sequelae of obesity.
Will A Reduction In Dietary AGEs Improve Insulin Sensitivity And Secretion In Overweight Individuals?
Funder
National Health and Medical Research Council
Funding Amount
$240,931.00
Summary
Advanced Gycation end-products (AGE) are formed when foods brown during heating, processing or long term storage. This study will examine the AGE content of a typical Australian diet. Also, an intervention study will be undertaken to determine whether an 75% reduction in AGE intake can reduce blood markers of chronic inflammation, improve insulin secretion and action and thus reduce diabetes and heart disease risk.
Preventing Impaired Beta-cell Plasticity, Insulin Secretion And Diabetes After IUGR
Funder
National Health and Medical Research Council
Funding Amount
$760,611.00
Summary
Babies who are born small are at increased risk of later diabetes, partly because restricting growth before birth also impairs development of insulin-secreting cells in the pancreas, impairing later insulin secretion and contributing to diabetes. We will define the mechanisms underlying impaired insulin secretion in a well-established animal model of fetal growth restriction. Importantly, we will also test interventions to improve insulin secretion after intrauterine growth restriction.
Obesity and insulin resistance are an escalating health problem in Australian adolescents. Unmanaged, they are likely to progress to type 2 diabetes and early atherosclerosis and which may pose a major burden on health care resources. However, treatment strategies are currently limited because of the lack of evidence. This PhD research aims to identify, summarise and test an effective and evidence-based approach of dietary management for overweight/obese adolescents and older children with clini ....Obesity and insulin resistance are an escalating health problem in Australian adolescents. Unmanaged, they are likely to progress to type 2 diabetes and early atherosclerosis and which may pose a major burden on health care resources. However, treatment strategies are currently limited because of the lack of evidence. This PhD research aims to identify, summarise and test an effective and evidence-based approach of dietary management for overweight/obese adolescents and older children with clinical insulin resistance or prediabetes.Read moreRead less
Can Reducing Sitting Time Influence Sustained Glycaemic Control In Middle-Aged And Older Office Workers With Type 2 Diabetes?
Funder
National Health and Medical Research Council
Funding Amount
$1,367,213.00
Summary
Sitting for too long, which is routine for most adults with type 2 diabetes, contributes to the serious and disabling complications of living with diabetes. In a controlled experimental trial among middle-aged and older workers with type 2 diabetes, this world-first study will determine the long-term benefits of reducing and breaking up sitting time. It will identify further practical ways to reduce the burden of serious complications among those living with type 2 diabetes.
Maximising The Population Impact Of Digital Self-management Programs To Improve Type 2 Diabetes Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$64,713.00
Summary
My PhD research will determine how user engagement with a digital diabetes program improves sustained diabetes outcomes and which program features contribute most to this improvement within disadvantaged people with diabetes. In addition to ensuring that such programs are equitable and optimise health gains of all Australians with T2DM, findings from my research will also help realise the potential of this technology to be used to address other chronic illness management.