Porous silicon biosensor for rapid detection of water-borne contaminants. We have recently demonstrated the rapid degradation of porous silicon by certain transition metal complexes known as biomimetic catalysts. The catalysed degradation forms the basis of a new sensor principle where the porous layer serves as matrix, transducer and signal amplification stage. Using this mechanism, we will develop a biosensor for the rapid detection of contaminants (toxins etc.) in water resources. Reservoir w ....Porous silicon biosensor for rapid detection of water-borne contaminants. We have recently demonstrated the rapid degradation of porous silicon by certain transition metal complexes known as biomimetic catalysts. The catalysed degradation forms the basis of a new sensor principle where the porous layer serves as matrix, transducer and signal amplification stage. Using this mechanism, we will develop a biosensor for the rapid detection of contaminants (toxins etc.) in water resources. Reservoir water treatment today is reactive rather than preventive because current analysis is slow. Our biosensor can be turned into a field kit to improve water quality management and prevent acts of deliberate sabotage to the water supply.Read moreRead less
Development of an interferometric nanoscale silicon biosensor. Voelcker et al. have recently demonstrated the rapid degradation of porous silicon by certain supramolecular transition metal complexes known as functional mimics of metalloproteins. The catalyzed degradation forms the basis of a new sensor principle where the porous layer serves as matrix, transducer and signal amplification stage. This project uses porous silicon degradation to develop a biosensor platform capable of detecting a ra ....Development of an interferometric nanoscale silicon biosensor. Voelcker et al. have recently demonstrated the rapid degradation of porous silicon by certain supramolecular transition metal complexes known as functional mimics of metalloproteins. The catalyzed degradation forms the basis of a new sensor principle where the porous layer serves as matrix, transducer and signal amplification stage. This project uses porous silicon degradation to develop a biosensor platform capable of detecting a range of analytes with high sensitivity. The project includes detection of an water-borne toxin, a plant virus and a cancer antigen as demonstrators of its wide applicability. Multiplexing of the biosensor to demonstrate its potential as high-throughput chip sensors is also included.Read moreRead less
Development of a Bioassay to Measure Xenoestrogens in Environmental Water Samples. Xenoestrogens in water can cause feminization of fish, amphibians and other wildlife, interfere with reproduction and increase cancer. This research aims to develop a new test to measure xenoestrogens in water, based on a measure of the estrogen-activated genes that are switched on when cells are exposed to estrogens. If the research is successful, it will produce the best test in the world for measuring the effe ....Development of a Bioassay to Measure Xenoestrogens in Environmental Water Samples. Xenoestrogens in water can cause feminization of fish, amphibians and other wildlife, interfere with reproduction and increase cancer. This research aims to develop a new test to measure xenoestrogens in water, based on a measure of the estrogen-activated genes that are switched on when cells are exposed to estrogens. If the research is successful, it will produce the best test in the world for measuring the effects of xenoestrogens on mammalian cells. The test can be used to develop better xenoestrogen removal processes, and to set limits for the levels of xenoestrogens permitted in rivers and creeks.Read moreRead less