Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560685
Funder
Australian Research Council
Funding Amount
$451,000.00
Summary
Scanning Probe Microscopy for Bioelectrochemistry. New methods to study the fundamental properties of biological samples, in particular proteins, are continuing to advance and impact on society. We will establish a leading edge facility for high-resolution imaging of biomolecules with redox functions. This will enable the continued development of new enzyme based diagnostic tests by understanding the dynamic nature of coupled electron and molecular interactions with redox enzymes in solution. Th ....Scanning Probe Microscopy for Bioelectrochemistry. New methods to study the fundamental properties of biological samples, in particular proteins, are continuing to advance and impact on society. We will establish a leading edge facility for high-resolution imaging of biomolecules with redox functions. This will enable the continued development of new enzyme based diagnostic tests by understanding the dynamic nature of coupled electron and molecular interactions with redox enzymes in solution. The bioelectrochemical imaging facility will be unique in Australia and establish an important cross-disciplinary approach within the international community.Read moreRead less
Solving the problem of detecting small molecules in complex samples: A Label-Free Electrochemical Immuno-biosensor for drugs and pesticides. Biosensors are portable analytical devices which can be used by the general public without specialist training. The proposed research will develop a biosensor for the detection of small molecules such as pesticides, poisons and drugs; a class of analytes where there is currently no viable biosensor technology. The simple to use device will benefit the Aus ....Solving the problem of detecting small molecules in complex samples: A Label-Free Electrochemical Immuno-biosensor for drugs and pesticides. Biosensors are portable analytical devices which can be used by the general public without specialist training. The proposed research will develop a biosensor for the detection of small molecules such as pesticides, poisons and drugs; a class of analytes where there is currently no viable biosensor technology. The simple to use device will benefit the Australian community by providing technology which will allow rapid and inexpensive monitoring of water as well as biomedical diagnosis. The research will also benefit Australia via providing the training of scientists to establish the new generation of Australia's bionanotechnology industry. Read moreRead less
The photonic immunochip: retrieving individual Enzyme-linked Immuno Sorbent Assay (ELISA) array-units using optical waveguide multicolour fluorescence. Improving the sensitivity and availability of in-vitro immuno-diagnostic tests is a critical goal towards developing real time efficient tools for the detection of infectious diseases, cancers, allergies and auto-immune diseases. The goal is to increase the sensitivity of these tests by reducing background noise that has been a feature of the com ....The photonic immunochip: retrieving individual Enzyme-linked Immuno Sorbent Assay (ELISA) array-units using optical waveguide multicolour fluorescence. Improving the sensitivity and availability of in-vitro immuno-diagnostic tests is a critical goal towards developing real time efficient tools for the detection of infectious diseases, cancers, allergies and auto-immune diseases. The goal is to increase the sensitivity of these tests by reducing background noise that has been a feature of the commonly used ELISA technology. This will be achieved by developing a novel optical integrated waveguide array supporting a large range of distributed tests, including several based on a novel multi-colour detection scheme. This massively parallel approach will underpin a new generation of low-cost, efficient diagnostic tests.Read moreRead less
Liquid light: aqueous bio-sensing in microstructured polymer optical fibres. This project builds on Australia's world-leading position in the development of microstructured polymer optical fibres, and applies the unique benefits they provide to for ultra- sensitive bio-sensing. By using the microstructure to simultaneously confine light and liquid, microstructured optical fibres provide a unique platform for ultra-sensitive spectroscopy and structural studies of biomolecules in solution. The wor ....Liquid light: aqueous bio-sensing in microstructured polymer optical fibres. This project builds on Australia's world-leading position in the development of microstructured polymer optical fibres, and applies the unique benefits they provide to for ultra- sensitive bio-sensing. By using the microstructure to simultaneously confine light and liquid, microstructured optical fibres provide a unique platform for ultra-sensitive spectroscopy and structural studies of biomolecules in solution. The work has profound implications both for fundamental science and applications, particularly in medical diagnostics.Read moreRead less
A Generic Solution for Interfacing Electrodes with Biological Media. Electrodes are the critical element of stimulating implantable devices such as cardiac pacemakers, bionic eyes and cochlear implants, the most commercially successful biosensors, and are emerging as key to new technologies for testing new drug leads using cells. In all these applications of electrodes in biology there has never been a solution to stopping unwanted adsorption of biological material onto the electrode that does ....A Generic Solution for Interfacing Electrodes with Biological Media. Electrodes are the critical element of stimulating implantable devices such as cardiac pacemakers, bionic eyes and cochlear implants, the most commercially successful biosensors, and are emerging as key to new technologies for testing new drug leads using cells. In all these applications of electrodes in biology there has never been a solution to stopping unwanted adsorption of biological material onto the electrode that does not dramatically decrease electrode performance. The proposed research finally provides a solution via surface modification. This strategy will enhance the performance of all the devices above and will open doors to new applications of electrochemistry within biology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454207
Funder
Australian Research Council
Funding Amount
$311,381.00
Summary
New Technology to Fight Crime and Terrorism: Laser Ablation Inductively Coupled Plasma Mass Spectrometer Facilities (LA-ICP-MS). Australia urgently needs new technologies to prevent and fight crime and terrorism. This equipment will address current outstanding problems in forensic science and related disciplines, namely the requirement to (1) analyse minute quantities of samples, (2) differentiate samples with similar matrices but trace differences, (3) analyse solid samples that are difficult t ....New Technology to Fight Crime and Terrorism: Laser Ablation Inductively Coupled Plasma Mass Spectrometer Facilities (LA-ICP-MS). Australia urgently needs new technologies to prevent and fight crime and terrorism. This equipment will address current outstanding problems in forensic science and related disciplines, namely the requirement to (1) analyse minute quantities of samples, (2) differentiate samples with similar matrices but trace differences, (3) analyse solid samples that are difficult to analyse by current techniques. This equipment is also vital for research which will improve the justice system, the quality of food and health products and increase industry competitiveness through novel industrial and environmental testing. Acquiring this infrastructure will safeguard and ensure Australia's continuing prosperity.Read moreRead less
Plasmon nanobiosensor for whole blood analysis. The new method will be able to detect specific disease markers or to identify subtle differences in protein content in complex dense analytes such as blood and other body fluids, of practical utility in diagnostic and clinical situations. It will also be relevant in other areas such as medical diagnostics of viral diseases, and for unsolved environmental monitoring problems such as the presence of specific microorganisms in industrial waste. Owing ....Plasmon nanobiosensor for whole blood analysis. The new method will be able to detect specific disease markers or to identify subtle differences in protein content in complex dense analytes such as blood and other body fluids, of practical utility in diagnostic and clinical situations. It will also be relevant in other areas such as medical diagnostics of viral diseases, and for unsolved environmental monitoring problems such as the presence of specific microorganisms in industrial waste. Owing to their design simplicity and low cost of components, the devices developed in this program will lend themselves well to the development of new commercial technologies for Australia.Read moreRead less