New Imaging Instrumentation and Algorithms for the Simultaneous Measurement of Multiple Radio-labelled Probes in vivo. Medical imaging plays an increasingly important role in basic biological research and health care. This project will lead to new imaging technologies that allow the simultaneous measurement of more than one biological process at a time in living subjects, providing new insights into disabling diseases, such as cancer and mental illness. An immediate benefit will be to strengthen ....New Imaging Instrumentation and Algorithms for the Simultaneous Measurement of Multiple Radio-labelled Probes in vivo. Medical imaging plays an increasingly important role in basic biological research and health care. This project will lead to new imaging technologies that allow the simultaneous measurement of more than one biological process at a time in living subjects, providing new insights into disabling diseases, such as cancer and mental illness. An immediate benefit will be to strengthen the expertise in biomedical engineering and instrumentation development in Australia, where we have international leadership. The technologies developed will provide advanced tools for making fundamental biological discoveries and translating them into biotechnological or clinical applications.Read moreRead less
Simultaneous measurement of brain function and behaviour in fully conscious laboratory animals. MicroPET is an advanced imaging technology that measures important biochemical processes, such as enzyme activity rates and receptor binding, in the living rodent brain. However, the requirement for the animal to be anaesthetised precludes the study of behavioural changes in response to sensory or drug stimulus during the imaging study. In this research, we will develop novel motion tracking and compu ....Simultaneous measurement of brain function and behaviour in fully conscious laboratory animals. MicroPET is an advanced imaging technology that measures important biochemical processes, such as enzyme activity rates and receptor binding, in the living rodent brain. However, the requirement for the animal to be anaesthetised precludes the study of behavioural changes in response to sensory or drug stimulus during the imaging study. In this research, we will develop novel motion tracking and computational algorithms that enable microPET to non-invasively image the brains of conscious, freely moving animals while simultaneously observing their behaviour. These new technologies will, for the first time, allow neuroscientists to study the genetic, behavioural and neurochemical correlates of brain disease.Read moreRead less
Novel Transmission Scanning and Computational Strategies for Quantitative microPET Imaging. Advances in detector technologies have led to the development and commercialisation of small animal imaging systems such as microPET which provide high resolution images of radioactive compounds in live animals, but the images can only be interpreted qualitatively. Our aim is to develop quantitative technologies for these new imaging systems. Major outcomes will include novel methods of measuring and corr ....Novel Transmission Scanning and Computational Strategies for Quantitative microPET Imaging. Advances in detector technologies have led to the development and commercialisation of small animal imaging systems such as microPET which provide high resolution images of radioactive compounds in live animals, but the images can only be interpreted qualitatively. Our aim is to develop quantitative technologies for these new imaging systems. Major outcomes will include novel methods of measuring and correcting for signal loss due to photon interactions in the body and integrated image reconstruction algorithms. This will lead to a new generation of quantitative imaging devices; the new technologies will be directly translatable to clinical imaging systems and will broaden the range of microPET applications in the life sciences.Read moreRead less
The Origin and Evolution of Cosmic Magnetism. This research will significantly advance our understanding of structure and evolution in the Universe, in keeping with Australia's outstanding track record of astronomical discovery. This program will also train students and build research capacity in the frontier area of X-ray astronomy, in which Australia currently has limited expertise. The instrumentation and techniques to be developed will lead to innovative transfers of technology to fields su ....The Origin and Evolution of Cosmic Magnetism. This research will significantly advance our understanding of structure and evolution in the Universe, in keeping with Australia's outstanding track record of astronomical discovery. This program will also train students and build research capacity in the frontier area of X-ray astronomy, in which Australia currently has limited expertise. The instrumentation and techniques to be developed will lead to innovative transfers of technology to fields such as telecommunications and medical imaging. These new facilities will also serve as vital stepping stones to the Square Kilometre Array, a billion-dollar international project which promises enormous economic, engineering and scientific opportunities for Australia.Read moreRead less
Special Research Initiatives - Grant ID: SR0567334
Funder
Australian Research Council
Funding Amount
$125,748.00
Summary
A Grid-Enabled National Archive of Nanostructural Imagery (GRANI). The Nanostructural Analysis Network Organization (NANO) is an Australian Major National Research Facility that provides access to a grid of advanced microscopic instruments for the nanostructural analysis of both physical materials and biological systems. The aim of this initiative is to provide the NANO community with a set of common, interoperable tools and services to enable more efficient, cost-effective storage, management, ....A Grid-Enabled National Archive of Nanostructural Imagery (GRANI). The Nanostructural Analysis Network Organization (NANO) is an Australian Major National Research Facility that provides access to a grid of advanced microscopic instruments for the nanostructural analysis of both physical materials and biological systems. The aim of this initiative is to provide the NANO community with a set of common, interoperable tools and services to enable more efficient, cost-effective storage, management, analysis and sharing of generated microscopic images, video and analytical data. The significance of the proposed middleware is that it will improve collaboration and reduce duplication across many disciplines, through a shareable, distributed national scientific image/video database.Read moreRead less
Multi-modal, Multi-dimensional Virtual Microscopy for Diagnostic Quantitative Pathology. This project will contribute to the development of a new generation of virtual microscopy (VM) systems that provide new and innovative features capable of significantly increasing the adoption of digital imaging technology throughout the field of pathology. These systems have the potential to significantly enhance the efficiency and efficacy of not only primary diagnostic workflows, but also aspects of profi ....Multi-modal, Multi-dimensional Virtual Microscopy for Diagnostic Quantitative Pathology. This project will contribute to the development of a new generation of virtual microscopy (VM) systems that provide new and innovative features capable of significantly increasing the adoption of digital imaging technology throughout the field of pathology. These systems have the potential to significantly enhance the efficiency and efficacy of not only primary diagnostic workflows, but also aspects of proficiency testing and continuing education vital for a vibrant, well regulated discipline. In addition, the project will contribute to our knowledge of the pathology assessed in the screening and diagnosis of cancers such as cervical, lung and bladder cancers.Read moreRead less
Enabling Technologies for Motion Corrected Positron Emission Tomography (PET) of Unanaesthetized Laboratory Animals. Small animal molecular imaging is a powerful tool in biological research and drug discovery. Anaesthesia is routinely used to avoid motion distortion, but can profoundly alter the biological process studied. This research will enable quantitative imaging of neurobiological phenomena in awake laboratory animals. It will create new opportunities for Australian basic researchers to ....Enabling Technologies for Motion Corrected Positron Emission Tomography (PET) of Unanaesthetized Laboratory Animals. Small animal molecular imaging is a powerful tool in biological research and drug discovery. Anaesthesia is routinely used to avoid motion distortion, but can profoundly alter the biological process studied. This research will enable quantitative imaging of neurobiological phenomena in awake laboratory animals. It will create new opportunities for Australian basic researchers to use innovative technology with expected high economic potential, and benefit small biotech companies by facilitating pre-clinical and clinical development of new pharmaceuticals. The new motion tracking and image reconstruction technologies developed will strengthen Australia's leading position in engineering and biomedical systems development.Read moreRead less
Advanced Processing for Through-the-Wall Radar Imaging. There is currently considerable interest around the world in imaging systems that can 'see' through-the-walls. This project is at the cutting edge of through-the-wall radar imaging research and technology. It will benefit both the defence and security industries, and position Australia among the leading countries in this technology, as only a handful of research teams around the world have the necessary background and expertise in this area ....Advanced Processing for Through-the-Wall Radar Imaging. There is currently considerable interest around the world in imaging systems that can 'see' through-the-walls. This project is at the cutting edge of through-the-wall radar imaging research and technology. It will benefit both the defence and security industries, and position Australia among the leading countries in this technology, as only a handful of research teams around the world have the necessary background and expertise in this area. The research outcomes will enhance the capability of the military, law enforcement, counter-terrorism, and search and rescue personnel. It will play a vital role in protecting and safeguarding Australia from terrorism and crime.Read moreRead less
Novel Motion Correction Technologies for Simultaneous Positron Emission Tomography and Magnetic Resonance Imaging. The recent development of the world's first prototype combined MR-PET scanner for human use has prompted immense interest. MR-PET is likely to revolutionize clinical diagnosis and basic research, by providing exquisite structural images co-registered with simultaneous functional PET images. We will exploit the as yet unexplored potential for motion information derived from the MR sy ....Novel Motion Correction Technologies for Simultaneous Positron Emission Tomography and Magnetic Resonance Imaging. The recent development of the world's first prototype combined MR-PET scanner for human use has prompted immense interest. MR-PET is likely to revolutionize clinical diagnosis and basic research, by providing exquisite structural images co-registered with simultaneous functional PET images. We will exploit the as yet unexplored potential for motion information derived from the MR system to be used to correct the simultaneously acquired PET data for patient motion. This research is an excellent opportunity for Australian researchers to make important contributions to an emerging technology with high economic potential, and will strengthen Australia's international position in engineering and biomedical systems development.Read moreRead less
The physics of planetary creation with the James Webb Space Telescope. This project aims to investigate the physics of solar system assembly. Understanding the origins of the Earth and our Solar System is one of the challenges for contemporary astronomy. By understanding the diverse chemistry and physical conditions on exoplanets, the project aims to directly address the question of if and where life is harbored around distant stars. This project will participate in the 2018 launch of the James ....The physics of planetary creation with the James Webb Space Telescope. This project aims to investigate the physics of solar system assembly. Understanding the origins of the Earth and our Solar System is one of the challenges for contemporary astronomy. By understanding the diverse chemistry and physical conditions on exoplanets, the project aims to directly address the question of if and where life is harbored around distant stars. This project will participate in the 2018 launch of the James Webb Space Telescope (JWST), which will carry an Australian-designed interferometer.Read moreRead less