Evaluating the impact of obesity on knee load over time in those who have undergone optimal surgical re-alignment after total knee replacement . This project investigates the impact of obesity on alignment and knee load over time in those who have undergone total knee replacement. This information is critical for understanding whether obesity results in increasing knee load after surgery which can lead to more rapid wearing of the knee surfaces and an earlier need for revision surgery.
Integrated Futures for the use of Motorised Mobility Devices. People using Motorised Mobility Devices (MMDs) face increased regulation. A pessimism exists about the future of MMDs because of the lack of evidence and explanation of MMD use in transport decision making. This project aims to fundamentally change knowledge about the everyday meanings and experiences of MMDs. The project seeks to provide comparative, trustworthy and in-depth baseline empirical data about how people who are reliant u ....Integrated Futures for the use of Motorised Mobility Devices. People using Motorised Mobility Devices (MMDs) face increased regulation. A pessimism exists about the future of MMDs because of the lack of evidence and explanation of MMD use in transport decision making. This project aims to fundamentally change knowledge about the everyday meanings and experiences of MMDs. The project seeks to provide comparative, trustworthy and in-depth baseline empirical data about how people who are reliant upon MMDs negotiate the current transport infrastructure. Expected outcomes with our Partner Organisation, Assistive Technology Services Australia, include a database of deliberative strategies. This project will benefit Australia’s urban and regional communities through a better understanding of transport. Read moreRead less
Evaluating the impact of information and communication technologies on organisational processes and outcomes: a multi-disciplinary, multi-method approach. Investment in new information and communication technologies (ICT) is a high-risk business. There is poor understanding of why so many ICTs fail in complex organisations This project will develop and test a Multi-method Evaluation Model (MEM) to measure the impact of ICT on organisational processes and outcomes in such organisations. The mod ....Evaluating the impact of information and communication technologies on organisational processes and outcomes: a multi-disciplinary, multi-method approach. Investment in new information and communication technologies (ICT) is a high-risk business. There is poor understanding of why so many ICTs fail in complex organisations This project will develop and test a Multi-method Evaluation Model (MEM) to measure the impact of ICT on organisational processes and outcomes in such organisations. The model addresses the practical complexity and political fragmentation of human practice in determining ICT use and outcomes, by considering organisational and socio-cultural factors. Key factors that predict acceptance, effective use and improvement in processes and outcomes will be identified. The generic predictive model will highlight factors which improve organisational processes and outcomes.Read moreRead less
Blood component interactions with polysaccharide biomaterials for vascular applications. Heart disease is the major killer of people in Australia and the Western world. It is due mainly to the blockage of vessels supplying the muscle of the heart with blood and nutrients, which can be replaced or by-passed but the supply of native vessels in the body is limited. Tissue engineering laboratories have been trying to develop blood vessels for this use for many years without significant success. T ....Blood component interactions with polysaccharide biomaterials for vascular applications. Heart disease is the major killer of people in Australia and the Western world. It is due mainly to the blockage of vessels supplying the muscle of the heart with blood and nutrients, which can be replaced or by-passed but the supply of native vessels in the body is limited. Tissue engineering laboratories have been trying to develop blood vessels for this use for many years without significant success. This application plans to understand the molecular signals contained within the sugar sequences used in a commonly used biomaterial chitosan that may be used in the construction of synthetic vascular grafts. If we can understand how blood cells interact with this biomaterial, we may be able to develop a blood vessel in the laboratory.Read moreRead less
Socio-cultural Factors and the Use of Therapeutic Opioids in Indonesia. This project aims to determine how legal, policy and socio-cultural factors influence the use of therapeutic opioids in Indonesia. The project expects to generate a nuanced understanding of the impact of non-medical considerations in contested areas of health policy through its multidisciplinary and multi-scalar approach. We expect outcomes to include a robust model of influences on decision-making that can be applied in Ind ....Socio-cultural Factors and the Use of Therapeutic Opioids in Indonesia. This project aims to determine how legal, policy and socio-cultural factors influence the use of therapeutic opioids in Indonesia. The project expects to generate a nuanced understanding of the impact of non-medical considerations in contested areas of health policy through its multidisciplinary and multi-scalar approach. We expect outcomes to include a robust model of influences on decision-making that can be applied in Indonesia and adapted for use in other national contexts. This should provide significant benefits, including an innovative training program to empower doctors and pharmacists to make evidence-based decisions about the potential risks and benefits, both medical and social, of opioid-based treatment options.Read moreRead less
Understanding Tendon Response to Sport and Exercise: Implications for Optimising Training, Injury Prevention and Accelerated Rehabilitation. This research will use frontier technologies to establish the effect of physical activity on tendon adaptation and injury. It will address National Research Priorities and lead to contemporary evidence-based physical activity practices to optimise health and fitness, prevent injury, and expedite rehabilitation after injury. Given the significant national in ....Understanding Tendon Response to Sport and Exercise: Implications for Optimising Training, Injury Prevention and Accelerated Rehabilitation. This research will use frontier technologies to establish the effect of physical activity on tendon adaptation and injury. It will address National Research Priorities and lead to contemporary evidence-based physical activity practices to optimise health and fitness, prevent injury, and expedite rehabilitation after injury. Given the significant national investment in sport, the rise in obesity, and the immense cost of sedentary behaviour and sport-related injuries, this research will have applications for enhancing physical activity recommendations that maintain health for all Australians. It will enhance Australia's leading position in international sport and sport science research and have beneficial applications for occupational health.Read moreRead less
New Conus-derived alpha-conotoxin analgesics for the treatment of chronic pain: structure, mode of action, delivery and disposition. Current product deficiencies in the area of pain management are forcing the pharmaceutical industry to develop new strategies for achieving analgesia and reduce their dependence on traditional, addictive opiate-based products. Structural modification of cone snail derived peptides will provide exciting new leads for achieving effective analgesia.
The application and consequences of e-governance for India’s fight against urban poverty. This project studies the deployment of biometric registration and social data bases for the delivery of welfare in India. It examines how social processes, local cultures and survival strategies shape these initiatives. What can be learned from the implementation phase of these path-finding social security schemes in third world conditions?
Improving the success of hybrid living shorelines for coastal protection. This project aims to improve the success of hybrid living shorelines that combine the restoration of mangroves and oysters with engineered structures to enhance restoration outcomes and coastal hazard resilience. It expects to generate new knowledge on the effectiveness of innovative coastal-manager-led solutions that have not yet been robustly evaluated. Expected outcomes of this project include delivery of the technical ....Improving the success of hybrid living shorelines for coastal protection. This project aims to improve the success of hybrid living shorelines that combine the restoration of mangroves and oysters with engineered structures to enhance restoration outcomes and coastal hazard resilience. It expects to generate new knowledge on the effectiveness of innovative coastal-manager-led solutions that have not yet been robustly evaluated. Expected outcomes of this project include delivery of the technical guidelines needed to practically design and implement nature-based coastal protection at scale. This should provide significant socio-economic and environmental benefits through improving Australia’s capacity to adapt to increased erosion and flood risk caused by climate change and coastal urbanisation.Read moreRead less
Going for gold: safe livelihoods for informal gold miners in South and Southeast Asia. Informal gold mining by the rural poor is transforming contemporary rural Asian economies. This project will focus on the community level, and on mineral-rich tracts in South and Southeast Asia, to explore how the livelihoods of the rural poor are changing in response to high gold prices.