Correction Of Friedreich Ataxia Induced Pluripotent Stem Cells By Non-viral Gene Therapy
Funder
National Health and Medical Research Council
Funding Amount
$63,270.00
Summary
Friedreich ataxia (FRDA) is an inherited progressive disorder of the nervous system and heart. Stem cell therapy has the potential to repair or replace damaged tissues and restore organ function in FRDA patients. The defect inherent in stem cells obtained from FRDA patients will be corrected by a gene therapy approach that will restore normal FRDA gene expression and addresses major safety concerns for the clinical use of corrected stem cells in transplantation medicine.
Improving The Treatment Of Neonatal Sepsis Through Vancomycin Pharmacokinetic And Pharmacodynamic Modelling
Funder
National Health and Medical Research Council
Funding Amount
$71,458.00
Summary
Our study will assess whether vancomycin, a key antibiotic used to treat severe infections in young infants, is best given as a continuous infusion or as multiple doses per day. We will determine which is the most effective method to achieve the target blood level of vancomycin and if current recommended target levels for vancomycin are appropriate for infants. Findings will be used to develop a bedside tool that will enable clinicians to tailor the dose of vancomycin to individual children.
A Novel Approach To Cytokine Blockade For The Treatment Of Systemic Lupus Erythematosus
Funder
National Health and Medical Research Council
Funding Amount
$137,700.00
Summary
Lupus is a disease of the immune system which can cause inflammation and damage to many organs and even death, often affecting young people in their prime of life. Current treatments are limited and often have undesirable side effects. Certain cells and molecules are thought to be responsible for causing lupus. This project will examine the effect of blocking one of these molecules as a means of treating lupus. It will also use gene and protein analysis of samples from lupus patients to see if r ....Lupus is a disease of the immune system which can cause inflammation and damage to many organs and even death, often affecting young people in their prime of life. Current treatments are limited and often have undesirable side effects. Certain cells and molecules are thought to be responsible for causing lupus. This project will examine the effect of blocking one of these molecules as a means of treating lupus. It will also use gene and protein analysis of samples from lupus patients to see if response to treatments can be predicted.Read moreRead less
Optimising Management Of Injection-related Infections In People Who Inject Drugs
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
People who inject drugs are a vulnerable group who are at increased risk of bacterial infections, which can lead to serious illness and death. This project aims to optimize management of bacterial infections in people who inject drugs. Measuring the current burden of infections, analysing different management strategies employed in hospitals and discussing attitudes and barriers to care with both healthcare workers and people who inject drugs will provide the evidence to optimize ongoing care.
Optimisation Of Beta-lactam Antibiotic Therapy As A Strategy To Improve Efficacy And Combat The Emergence Of Resistance
Funder
National Health and Medical Research Council
Funding Amount
$122,714.00
Summary
Antibiotic resistance is a global health priority that threatens to compromise advances in modern medicine to return practices to the pre-antibiotic era. Critically ill and patients with impaired immune function represent a vulnerable group who struggle to fight infections and who rely heavily on lifesaving antibiotics. This project aims to investigate how the efficacy of antibiotics can be optimised to prevent the emergence of resistance and preserve their effectiveness for the future.
Gene Therapy And Bone Marrow Transplantation For Treatment Of Experimental Autoimmune Uveitis
Funder
National Health and Medical Research Council
Funding Amount
$78,445.00
Summary
Bone marrow stem cells modified to express self antigen is proposed as a treatment for experimental autoimmune uveitis. A major goal of this research is to investigate the impact and possible mechanism of gene therapy on the development and progression of autoimmune disease in the eye to prevent or reduce the severity of disease.
Antibody Targeted Virus Particles For A Gene Therapy Approach To Inhibiting Atheroschlerosis Development
Funder
National Health and Medical Research Council
Funding Amount
$95,313.00
Summary
I am a Biotechnologist and my research looks into ways of preventing Atherosclerosis. Atherosclerosis is the build up of plaques in artery walls, and is the major precursor condition to stroke and myocardial infarction (heart attack). My project focuses on a preventative gene therapy which will be delivered specifically to early stage plaques. The gene will inhibit one of the earliest developmental stages of atherosclerosis: recruitment of immune cells to these sites, and so prevent their growth ....I am a Biotechnologist and my research looks into ways of preventing Atherosclerosis. Atherosclerosis is the build up of plaques in artery walls, and is the major precursor condition to stroke and myocardial infarction (heart attack). My project focuses on a preventative gene therapy which will be delivered specifically to early stage plaques. The gene will inhibit one of the earliest developmental stages of atherosclerosis: recruitment of immune cells to these sites, and so prevent their growth.Read moreRead less
Antimicrobial Stewardship – Establishing An Effective Model For Australian Private Hospitals
Funder
National Health and Medical Research Council
Funding Amount
$55,807.00
Summary
Inappropriate and overuse of antibiotics in hospitals has accelerated world-wide antimicrobial resistance. Strategies to improve antibiotic prescribing have been effective in slowing down antibiotic resistance, however there has been little uptake of these strategies in Australian private hospitals. Needs, resources, and current barriers for these strategies will be investigated in the private hospital setting and results will be used to construct a program model that can be adopted by private h ....Inappropriate and overuse of antibiotics in hospitals has accelerated world-wide antimicrobial resistance. Strategies to improve antibiotic prescribing have been effective in slowing down antibiotic resistance, however there has been little uptake of these strategies in Australian private hospitals. Needs, resources, and current barriers for these strategies will be investigated in the private hospital setting and results will be used to construct a program model that can be adopted by private hospitals in AustraliaRead moreRead less
Improving Health-related Quality Of Life In Patients Receiving Home Mechanical Ventilation
Funder
National Health and Medical Research Council
Funding Amount
$121,793.00
Summary
Home mechanical ventilation (HMV) is a treatment that assists someone to breathe using a machine. People may need HMV when their breathing has failed due to conditions such as chronic obstructive pulmonary disease (COPD), neuromuscular disease (NMD) or severe obesity. This project will examine the quality of life of patients receiving HMV in Australia and Canada. It will also determine if we can improve the treatment by using a sleep study to monitor breathing when patients first start HMV.