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Chronic pain afflicts 1 in 5 Australians; it is one of our most expensive health care problems. Prof Moseley's research asks: (1) Why do some people get chronic pain but others don't? (ii) How can we treat chronic pain so sufferers can return to a meaningful, productive and comfortable life? (iii) How can we stop chronic pain from developing in the first place? His research involves behavioural and physiological experiments in humans, that lead to new treatments, which are tested in clinical tri ....Chronic pain afflicts 1 in 5 Australians; it is one of our most expensive health care problems. Prof Moseley's research asks: (1) Why do some people get chronic pain but others don't? (ii) How can we treat chronic pain so sufferers can return to a meaningful, productive and comfortable life? (iii) How can we stop chronic pain from developing in the first place? His research involves behavioural and physiological experiments in humans, that lead to new treatments, which are tested in clinical trials.Read moreRead less
The Role Of Endometrial Stem Cells In Women’s Reproductive Health And Disease, And Their Use In Cell Based Therapies
Funder
National Health and Medical Research Council
Funding Amount
$727,765.00
Summary
The endometrial lining of the uterus rapidly grows and sheds each month in reproductive age women. My discovery of 2 types of endometrial stem cells has changed our understanding of how endometrium grows and how abnormalities in this process lead to gynaecological disease. This project will characterise the role of endometrial stem cells in endometriosis and examine how endometrial mesenchymal stem cells can be used as a cell-based therapy for pelvic organ prolapse.
Clinically Severe Obesity: A Better Understanding Of A Complex Condition, Improving Health Outcomes Through Effective Therapies, And Delivering A Comprehensive Clinical Pathway.
Funder
National Health and Medical Research Council
Funding Amount
$701,539.00
Summary
Clinically severe obesity impacts on the health of 7-8% or 1.5 million Australians, yet poor access to integrated effective care. This challenging area of healthcare is distorted by perceptions and beliefs that are frequently contrary to clinical and physiological research findings. Professor Dixon’s plan is to: 1) To learn more about clinically severe obesity, 2) improve the assessment and delivery of effective care, and 3) improve clinical capacity to better care for these Australians.
Germinal Centres, Rogue B Cells And The Genesis Of Immunological Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$753,300.00
Summary
This study will determine how the immune system is normally prevented from producing autoantibodies that target the body's own cells and how this fails in autoimmune diseases such as lupus. Targeted studies of a newly discovered "rogue" white blood cell will also provide new clues on how autoimmune diseases arise. In addition, modeling of human immunological disease in mice via CRISPR/Cas9 mutagenesis will provide valuable new insights into their causes and potential treatments.
We aim to grow body tissues for surgery, including heart muscle, liver and pancreatic islets (for diabetes) and will investigate using stem cells to repair the brain after stroke. We will attempt to boost the expansion of blood vessels in growing tissues using molecular tools we have found crucial for cell signaling. In growing heart tissues and in stroke we will improve drugs that might boost the potential of stem cells to regenerate damaged tissues
Molecular Approaches To Cardiac Development, Disease And Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$863,910.00
Summary
Prof Harvey’s work explores the molecular and cellular networks that underpin heart development in the embryo and heart regeneration in the adult, and how these networks unravel in heart disease. Based on this knowledge, his work seeks to develop novel approaches for alleviating suffering in babies with congenital heart defects and adults enduring the devastating consequences of heart attack or heart failure.
The Role Of Maternal Asthma In The Health Of Mother, Fetus And Child
Funder
National Health and Medical Research Council
Funding Amount
$621,458.00
Summary
A/Prof Clifton is a world leader in the area of maternal asthma and pregnancy. Her strengths relate to the fact that she can interface between basic science and the clinic in order to change clinical practice and policy. She consistently publishes her work and is regularly invited as a plenary speaker. She is a recognised leader in her field by her many prestigious appointments. She was awarded an outstanding mentor award 2011 in recognition of her contribution to student supervision and staff m ....A/Prof Clifton is a world leader in the area of maternal asthma and pregnancy. Her strengths relate to the fact that she can interface between basic science and the clinic in order to change clinical practice and policy. She consistently publishes her work and is regularly invited as a plenary speaker. She is a recognised leader in her field by her many prestigious appointments. She was awarded an outstanding mentor award 2011 in recognition of her contribution to student supervision and staff mentoring.Read moreRead less
The transplantation of healthy stem cells from a donor into a recipient with blood cancer (stem cell transplantation) is the most effective curative therapy for the majority of patients. Unfortunately this process results in unwanted, often fatal, side effects including infection, a rejection process known as graft-versus-host disease and in some patients, the leukaemia still recurs. This research will refine new treatments focused on overcoming these limitations and improving transplant outcome
My goal is to boost the immune system against cancer to develop new therapies. I aim to do this by genetically engineering the immune system and using drugs to help strengthen white blood cells of the immune system. Tumors can actively fight immunity by producing suppressive molecules. I am seeking to identify and understand these molecules in order to block them and help the immune system fight cancer. Using this knowledge, I aim to start new clinical trials for cancer.
Prevention And Management Of Chronic Disease In Primary Health Care
Funder
National Health and Medical Research Council
Funding Amount
$898,008.00
Summary
Over the past 10 years, Mark Harris has developed and led an innovate program of research on better ways to prevent and manage chronic disease in primary health care. This has included research on early intervention to assess and reduce the risk factors for these conditions involving innovative approaches to patient education; team based care; information and decision support systems. This research is now being extended to focus on disadvantaged groups and communities.