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Inferring Global Regulatory Architecture Of Human Gene Expression In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$47,427.00
Summary
Our genome encodes ~25,000 genes that shape out an individual from head to toe. Malfunction of a particular gene could cause fatal health problem or disease. Nonetheless, the mis-regulation of functioning genes can also result in serious diseases. In this study, we are going to use large-scale gene regulation information and advanced computing techniques to clarify the regulation network of human genome on a global level. Hence, helping us to understand more about diseases of gene transcription.
Identifying Molecular Signatures Of Type 1 Diabetes.
Funder
National Health and Medical Research Council
Funding Amount
$49,442.00
Summary
Type 1 diabetes is caused by loss of the insulin-producing beta cells of the pancreas. Certain white blood cells of the immune system direct a damaging inflammatory response towards beta cells. Patients become ill once most of the beta cells are destroyed. This project aims to identify molecular signatures within subjects' blood which reflect the destruction. These markers will help predict diabetes risk, assess severity and response to treatment, as well as define targets for intervention.