Monomeric C-reactive Protein As Pathogenic Factor And Therapeutic Target In Athero-thrombotic Disease.
Funder
National Health and Medical Research Council
Funding Amount
$86,570.00
Summary
Vascular disease of the heart, brain and limbs affects many people in Australia and throughout the world. Current treatments assist in slowing the development and progression of established disease, but new developments are required. This project will investigate the role of C-reactive protein in vascular disease and evaluate its potential as a new therapeutic target in the future.
Hypertension Induced Inflammation In The Endothelium: The Signalling Pathways Involved
Funder
National Health and Medical Research Council
Funding Amount
$58,313.00
Summary
Patients with high blood pressure are at an increased risk of heart attack and stroke in western societies. It appears that increased pressure induces an inflammation response which leads to the development of atherosclerosis. The aim of this project is to understand the vascular inflammatory mechanisms induced by high blood pressure with the view to prevent blood pressure-related complications such as atherosclerosis.
The Effect Of Defective Iron Handling On Immune Function And Pseudomonas Aeruginosa Infection In The Cystic Fibrosis Lung
Funder
National Health and Medical Research Council
Funding Amount
$97,213.00
Summary
In this research higher degree I will study the effects of iron on airway sepsis in cystic fibrosis (CF), with a particular focus on the major pathogen Pseudomonas aeruginosa. Increased concentrations of iron have been described in the CF lung, and CF airway epithelial cells display abnormal iron handling which facilitates P. aeruginosa growth. I will explore imposed iron limitation combined with conventional antibiotics as a new therapeutic strategy for treatment of chronic airway infection.
Investigation Of The Beneficial Arm Of The Renin-Angiotensin System (RAS) To Formulate Potential Therapies In Liver Diseases
Funder
National Health and Medical Research Council
Funding Amount
$71,765.00
Summary
Severe liver damage due to chronic hepatitis and other common liver diseases is now a major cause of illness and death in Australia. This project will examine how a hormone system contributes to the development of liver damage in these diseases. We will study whether drugs targeting this system can be used to reduce liver scarring and prevent the development of severe liver damage and its complication.
A Study Of The Relationship Between Vitamin D Status And The Severity And Outcomes Of Chronic Non-cholestatic Liver Disease
Funder
National Health and Medical Research Council
Funding Amount
$133,351.00
Summary
Vitamin D deficiency is associated with common and severe conditions such as cancer, cardiovascular disease, autoimmune disease and diabetes. Recent studies suggest that vitamin D deficiency also worsens the severity and prognosis of chronic liver disease and that vitamin D replacement may improve outcomes. This research will further investigate the relationship of vitamin D deficiency to liver disease caused by the common conditions hepatitis B and C and non-alcoholic fatty liver disease and th ....Vitamin D deficiency is associated with common and severe conditions such as cancer, cardiovascular disease, autoimmune disease and diabetes. Recent studies suggest that vitamin D deficiency also worsens the severity and prognosis of chronic liver disease and that vitamin D replacement may improve outcomes. This research will further investigate the relationship of vitamin D deficiency to liver disease caused by the common conditions hepatitis B and C and non-alcoholic fatty liver disease and the impact of vitamin D replacement.Read moreRead less