Re-evaluating forager-farmer plant use in Anatolia’s neolithic transition. This project aims to apply new techniques of archaeological residue analysis to artefacts, sediments, tools and skeletal remains from early Turkish forager-farmer and critically evaluate the role of crops and wild plant foods in the earliest development of farming outside southwest Asia’s Fertile Crescent. Results will allow a new understanding of how cropping came to dominate ancient economies and evaluate the validity o ....Re-evaluating forager-farmer plant use in Anatolia’s neolithic transition. This project aims to apply new techniques of archaeological residue analysis to artefacts, sediments, tools and skeletal remains from early Turkish forager-farmer and critically evaluate the role of crops and wild plant foods in the earliest development of farming outside southwest Asia’s Fertile Crescent. Results will allow a new understanding of how cropping came to dominate ancient economies and evaluate the validity of existing methods and understandings of this phenomenon. Drawing on and developing international collaborations, the project will enhance Australia's visibility in agricultural origins research, increase research capacity in this field and develop cultural, education and economic opportunities with and in Turkey.Read moreRead less
Seth, God of Confusion: the archaeology of a cult centre in Egypt. This project aims to examine the growth and survival of the cult of Seth in Egypt's Western Desert against the background of the cult's suggested proscription elsewhere in the ancient state. Through detailed excavation and radiometric dating of the cult centre in Dakhleh Oasis, it aims to explore the proposition that the continued veneration of Seth can be read as a sign of regional independence. This is intended to challenge the ....Seth, God of Confusion: the archaeology of a cult centre in Egypt. This project aims to examine the growth and survival of the cult of Seth in Egypt's Western Desert against the background of the cult's suggested proscription elsewhere in the ancient state. Through detailed excavation and radiometric dating of the cult centre in Dakhleh Oasis, it aims to explore the proposition that the continued veneration of Seth can be read as a sign of regional independence. This is intended to challenge the orthodox view that Egypt operated as a monolithic state; reshaping how we approach ancient Egyptian religion and administration. In doing so, the study is expected to position an Australian research team at the forefront of contemporary scholarship on Egypt, enhancing our national reputation in the promotion and preservation of global heritage.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100300
Funder
Australian Research Council
Funding Amount
$430,912.00
Summary
Novel gestural technologies for musicians with physical disability. This project aims to address the under-representation of people with disability in the Australian music industry by developing innovative, accessible gestural instruments. Teaming up with key industry partner, YourDNA Creative Arts, an accessibler arts organisation, this interdisciplinary project expects to generate new knowledge in instrument design, inclusive technology and creative artificial intelligence. Using mixed-methodo ....Novel gestural technologies for musicians with physical disability. This project aims to address the under-representation of people with disability in the Australian music industry by developing innovative, accessible gestural instruments. Teaming up with key industry partner, YourDNA Creative Arts, an accessibler arts organisation, this interdisciplinary project expects to generate new knowledge in instrument design, inclusive technology and creative artificial intelligence. Using mixed-methodologies, expected outcomes include music and performance which is socially inclusive, economic participation, and the health and well-being of musicians with disability. This should provide significant benefits to Australian society by breaking down barriers that hinder their effective participation in society.Read moreRead less
Shedding light on Neanderthal histories using luminescence chronologies. This project aims to develop unprecedented reconstructions of Neanderthal evolution, cultural and extinction histories at previously undatable or understudied European archaeology sites using a versatile luminescence dating toolkit. It will integrate multiple dating methods, palaeoclimate proxies and palaeoecological data to provide comprehensive knowledge of the timing, context and nature of Neanderthal evolution. Expected ....Shedding light on Neanderthal histories using luminescence chronologies. This project aims to develop unprecedented reconstructions of Neanderthal evolution, cultural and extinction histories at previously undatable or understudied European archaeology sites using a versatile luminescence dating toolkit. It will integrate multiple dating methods, palaeoclimate proxies and palaeoecological data to provide comprehensive knowledge of the timing, context and nature of Neanderthal evolution. Expected outcomes include unravelling past human responses to climate change, elucidating regional occupation patterns, emergence of complex behaviours, and causes of Neanderthal demise; with benefits for refining our own species deep-time evolutionary trajectory and global expansion across different regions, including Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100964
Funder
Australian Research Council
Funding Amount
$443,869.00
Summary
Statistical approaches for spatial genomics at single cell resolution. Cells cooperate to form complex, dynamic and varied tissue structures. This project aims to develop statistical and computational approaches to analyse spatial genomics data, a novel technology that retains vital spatial information at single cell resolution while detecting RNA molecules for hundreds of genes. Observing the molecular activity of cells in their spatial context is critical for tackling key biological questions, ....Statistical approaches for spatial genomics at single cell resolution. Cells cooperate to form complex, dynamic and varied tissue structures. This project aims to develop statistical and computational approaches to analyse spatial genomics data, a novel technology that retains vital spatial information at single cell resolution while detecting RNA molecules for hundreds of genes. Observing the molecular activity of cells in their spatial context is critical for tackling key biological questions, such as how tumour cells behave during malignancy or how stem cells determine their fate. Expected outcomes also include techniques to fully harmonise spatial and non-spatial genomics datasets, and methods toward understanding the complex relationships among cells in their environment, revealing novel cell biology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100133
Funder
Australian Research Council
Funding Amount
$657,987.00
Summary
An Open Access Native Mass Spectrometry Facility. This project aims to create a world-class Native Mass Spectrometry Facility to allow measurement of proteins, protein complexes and other biomolecules, in a way such that key structural information is maintained. This instrumentation will be the first of its type in Australia allowing measurement of very high mass ions with high precision and accuracy. A better understanding of protein structure will enable new discoveries in chemistry, biotechn ....An Open Access Native Mass Spectrometry Facility. This project aims to create a world-class Native Mass Spectrometry Facility to allow measurement of proteins, protein complexes and other biomolecules, in a way such that key structural information is maintained. This instrumentation will be the first of its type in Australia allowing measurement of very high mass ions with high precision and accuracy. A better understanding of protein structure will enable new discoveries in chemistry, biotechnology and medicinal research. Read moreRead less
Viral capsids as high-efficiency nanoreactors. This project aims to develop state-of-the-art single-molecule imaging to visualise DNA synthesis inside authentic retroviral capsids in real time. The project expects to generate new knowledge in the fields of virology, synthetic biology, and nanotechnology by utilising cutting-edge fluorescent labelling reagents and microscopy technology. Expected outcomes include a comprehensive description of retrovirus reverse transcription, development of innov ....Viral capsids as high-efficiency nanoreactors. This project aims to develop state-of-the-art single-molecule imaging to visualise DNA synthesis inside authentic retroviral capsids in real time. The project expects to generate new knowledge in the fields of virology, synthetic biology, and nanotechnology by utilising cutting-edge fluorescent labelling reagents and microscopy technology. Expected outcomes include a comprehensive description of retrovirus reverse transcription, development of innovative biophysical techniques for the study of viruses, and an understanding of the engineering principles at play in natural nano-reactors. This project anticipates contributing advanced capabilities in bionanotechnology, benefiting therapeutic, biotechnology and synthetic biology applications.Read moreRead less
“Beacons in the Night” unveiling how galaxies light up dark matter. How dark matter influences the formation and evolution of galaxies is to this day an outstanding question in astrophysics. To answer it, world-class facilities and a unique combination of observations and theory are required. This DP team, a world-class team of observers and theorists, will tackle this question by leveraging on two multi-million dollar projects: the MAGPI galaxy survey and the hydrodynamical simulations suite EA ....“Beacons in the Night” unveiling how galaxies light up dark matter. How dark matter influences the formation and evolution of galaxies is to this day an outstanding question in astrophysics. To answer it, world-class facilities and a unique combination of observations and theory are required. This DP team, a world-class team of observers and theorists, will tackle this question by leveraging on two multi-million dollar projects: the MAGPI galaxy survey and the hydrodynamical simulations suite EAGLE-XL. MAGPI will deliver exquisite kinematics for hundreds of galaxies in the middle ages of the Universe, providing a view to the effect of dark matter on galaxies at this critical time, while EAGLE-XL represents the technological frontier in simulations and provides the best interpretative framework for MAGPI.Read moreRead less
The physiological importance of GLP-1R and GIPR dimerisation. Cell surface receptors are vital for relaying information from hormones to the cell to influence cell function, and ultimately physiological responses. Receptors can form oligomers with other receptors, but whether this can influence cellular and physiological responses is not yet defined. This biology-based project aims to bridge this knowledge gap by studying the dimerisation between two related receptors involved in whole body meta ....The physiological importance of GLP-1R and GIPR dimerisation. Cell surface receptors are vital for relaying information from hormones to the cell to influence cell function, and ultimately physiological responses. Receptors can form oligomers with other receptors, but whether this can influence cellular and physiological responses is not yet defined. This biology-based project aims to bridge this knowledge gap by studying the dimerisation between two related receptors involved in whole body metabolic homeostasis. Our team will deliver new knowledge into the disciplines of pharmacology, cellular biology, metabolism and physiology, and provide interdisciplinary research training to students and junior scientists, and strengthen research collaboration within and outside of Australia.Read moreRead less
Molecular mechanisms of mechanosensation and shape regulation in cells. This project aims to explore how cells physically sense and respond to the surrounding environment on a molecular level. Physical distortion of erythrocytes doubles their glucose consumption and increases cation membrane flux five-fold. This mechanism involves opening of the mechanosenstive ion channel Piezo1. This project will include a kinetic description of these phenomena, with a goal to establish a predictive mathematic ....Molecular mechanisms of mechanosensation and shape regulation in cells. This project aims to explore how cells physically sense and respond to the surrounding environment on a molecular level. Physical distortion of erythrocytes doubles their glucose consumption and increases cation membrane flux five-fold. This mechanism involves opening of the mechanosenstive ion channel Piezo1. This project will include a kinetic description of these phenomena, with a goal to establish a predictive mathematical model of the regulation of cell-shape and volume. The project will provide an understanding of mechanisms operating when cells and tissues are succumbing to trauma and invasion, and how to control these processes on a molecular level.Read moreRead less