Why certain viruses don't get along in mosquitoes. The molecular mechanism. The overall goal of this project is to obtain an understanding of how certain insect-only viruses make mosquitoes incapable of transmitting diseases. These viruses, called insect-specific flaviviruses, can be employed as biocontrol agents for mosquito-borne human and veterinary diseases. However as it is currently unknown how exactly they affect mosquitoes, the safety and efficacy of their use can't be predicted. The pro ....Why certain viruses don't get along in mosquitoes. The molecular mechanism. The overall goal of this project is to obtain an understanding of how certain insect-only viruses make mosquitoes incapable of transmitting diseases. These viruses, called insect-specific flaviviruses, can be employed as biocontrol agents for mosquito-borne human and veterinary diseases. However as it is currently unknown how exactly they affect mosquitoes, the safety and efficacy of their use can't be predicted. The proposed project will dissect the very intricate mechanisms of interactions between insect-specific flaviviruses and mosquitoes and explain how exactly they prevent disease transmission. It should generate novel fundamental knowledge, implement innovative methodologies and provide training for students and junior scientist. Read moreRead less
Breaking through the Gram-negative cell barrier. This project aims to develop fundamental knowledge of the cell envelope in Gram-negative bacteria, which functions as a permeability barrier to small molecules. Combining innovative functional genomics with biochemistry, this project will determine how small molecules can pass across the cell envelope, and the chemical properties that they need to do so. Some Gram-negative bacteria are human pathogens and cause serious infections, whereas others a ....Breaking through the Gram-negative cell barrier. This project aims to develop fundamental knowledge of the cell envelope in Gram-negative bacteria, which functions as a permeability barrier to small molecules. Combining innovative functional genomics with biochemistry, this project will determine how small molecules can pass across the cell envelope, and the chemical properties that they need to do so. Some Gram-negative bacteria are human pathogens and cause serious infections, whereas others are used in biotechnology for biosynthetic chemical production or bioremediation. This project expects to help the future development of new antibiotics and assist in the design of strains to be used in biotechnological applications.Read moreRead less
Peptides and Proteins for Fighting Pests and Protecting the Environment. This project aims to use peptides and proteins to fight pests and protect the environment, which is significant because current practices have unintended harmful effects and are unsustainable. Achieving these aims must first involve scientific development of ecofriendly lead molecules. This project will develop platform technologies for the design of bioactive peptides or proteins based on molecules used naturally for highl ....Peptides and Proteins for Fighting Pests and Protecting the Environment. This project aims to use peptides and proteins to fight pests and protect the environment, which is significant because current practices have unintended harmful effects and are unsustainable. Achieving these aims must first involve scientific development of ecofriendly lead molecules. This project will develop platform technologies for the design of bioactive peptides or proteins based on molecules used naturally for highly selective functions in communication and defence. Expected outcomes include novel peptide and protein leads and improved strategies for developing them, which will lead to new and safer ways of protecting biodiversity and food security that are expected to reduce our environmental footprint and bring economic benefits.Read moreRead less
Advances in data integration modelling for infectious disease response. This project aims to develop powerful mathematical frameworks that integrate data from multiple sources to facilitate informed decisions in response to the threat of present, and future, infectious diseases. The project expects to generate new knowledge in mathematics by advancing the tools for incorporating multiple data sources into models of infectious diseases. The expected outcomes include enhanced capacity to predict s ....Advances in data integration modelling for infectious disease response. This project aims to develop powerful mathematical frameworks that integrate data from multiple sources to facilitate informed decisions in response to the threat of present, and future, infectious diseases. The project expects to generate new knowledge in mathematics by advancing the tools for incorporating multiple data sources into models of infectious diseases. The expected outcomes include enhanced capacity to predict spatiotemporal changes in transmission of infectious diseases. This project should provide significant benefits in the advancement of modelling techniques broadly applicable to infectious disease settings, which will be demonstrated for antimalarial drug resistance – a major threat to malaria elimination.
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Improving disease resilience in ecosystems using synthetic biology. This project aims to use the latest methods in synthetic biology to conserve species threatened by disease, through characterising and enhancing immunity. Emerging infectious diseases are a major threat to ecosystems and new methodologies are needed to fight them. Chytridiomycosis is the most devastating disease of vertebrates, causing population declines in over 200 amphibian species worldwide. The expected outcomes of the proj ....Improving disease resilience in ecosystems using synthetic biology. This project aims to use the latest methods in synthetic biology to conserve species threatened by disease, through characterising and enhancing immunity. Emerging infectious diseases are a major threat to ecosystems and new methodologies are needed to fight them. Chytridiomycosis is the most devastating disease of vertebrates, causing population declines in over 200 amphibian species worldwide. The expected outcomes of the project are improved understanding and increased immunity of frogs to chytridiomycosis and restoration of frogs into the environment. The project will demonstrate the usefulness of synthetic biology to tackle disease and preserve biodiversity in the landscape for similarly threatened wildlife in Australia and overseas.Read moreRead less
Bridging the gap between global mechanics and regional imaging in the lungs. The detailed mechanics of breathing are not well understood, due to a lack of regional lung measurement techniques. This project aims to develop a powerful analysis tool to image in vivo mechanical properties of the lungs. The expected outcome of this project is a novel platform for investigation and understanding of lung function, enabling information previously only available for the whole lung to be calculated for lo ....Bridging the gap between global mechanics and regional imaging in the lungs. The detailed mechanics of breathing are not well understood, due to a lack of regional lung measurement techniques. This project aims to develop a powerful analysis tool to image in vivo mechanical properties of the lungs. The expected outcome of this project is a novel platform for investigation and understanding of lung function, enabling information previously only available for the whole lung to be calculated for local lung regions within the body. The image analysis methods developed are intended to enable respiratory researchers to investigate lung function in unprecedented detail, leading to new insights into the workings of this complicated and vital organ. Read moreRead less
Programmed cell death signalling in innate immunity. This proposal aims to address the under-explored potential for programmed cell death to promote innate immune cell signalling, which is a critical and fundamental biological process. It aims to generate new knowledge in the areas of cell death and innate signalling using innovative interdisciplinary approaches and discover new molecules that impact innate inflammatory responses. The expected outcomes of this project are to enhance our basic un ....Programmed cell death signalling in innate immunity. This proposal aims to address the under-explored potential for programmed cell death to promote innate immune cell signalling, which is a critical and fundamental biological process. It aims to generate new knowledge in the areas of cell death and innate signalling using innovative interdisciplinary approaches and discover new molecules that impact innate inflammatory responses. The expected outcomes of this project are to enhance our basic understanding of cell death, and build interdisciplinary collaborations. This work should provide significant benefit to the economy and health of Australians, as it is expected to identify molecules that will be of interest to the pharmaceutical and biotechnology industries.Read moreRead less
Manipulating population sex ratio to eradicate invasive mouse populations. This project aims to use house mice, an Australian pest of economic importance which is also a highly tractable system for testing evolutionary theory and generating practical outcomes. Manipulating population sex ratio is a powerful tool for either enhancing the viability of threatened species or decimating pests. However, despite much scientific effort testing sex ratio theory, the cryptic mechanisms driving sex allocat ....Manipulating population sex ratio to eradicate invasive mouse populations. This project aims to use house mice, an Australian pest of economic importance which is also a highly tractable system for testing evolutionary theory and generating practical outcomes. Manipulating population sex ratio is a powerful tool for either enhancing the viability of threatened species or decimating pests. However, despite much scientific effort testing sex ratio theory, the cryptic mechanisms driving sex allocation remain unidentified, hindering progress in these fields. The project will identify the mechanisms by which sex ratio adjustments are made and establish how individual-level responses influence insular population structure and growth. It will provide benefits by assisting Australia's efforts in eradicating invasive mouse populations.Read moreRead less
Microbe-produced repellents and their roles in marine pathogen behaviours. Economic losses caused by disease outbreaks in marine fisheries and aquaculture exceed US$6 billion per year globally. Decades of research in human and plant pathogens have revealed that the ability of pathogens to infect their host is governed by behaviours; however our understanding of the chemical cues affecting the behaviour of marine pathogens is very poor. This research program aims to combine new approaches in micr ....Microbe-produced repellents and their roles in marine pathogen behaviours. Economic losses caused by disease outbreaks in marine fisheries and aquaculture exceed US$6 billion per year globally. Decades of research in human and plant pathogens have revealed that the ability of pathogens to infect their host is governed by behaviours; however our understanding of the chemical cues affecting the behaviour of marine pathogens is very poor. This research program aims to combine new approaches in microfluidics and chemical imaging to identify the cues that govern the behaviour of marine pathogens. Expected outcomes include an improved capacity to predict, monitor and manage marine diseases, as well as novel strategies to prevent disease outbreaks, helping to protect Australia’s valuable marine estate.Read moreRead less
Detecting and tracking alertness using speech biometrics. Traditional tests for detecting and tracking alertness are limited by their accuracy and inability to be administered without stopping work. This project aims to investigate how speech can be used to monitor changes in performance resulting from sleep deprivation and successive night shifts. The expected outcomes are 1) new knowledge on how sensitive speech and language features are for detecting change in alertness, and 2) development an ....Detecting and tracking alertness using speech biometrics. Traditional tests for detecting and tracking alertness are limited by their accuracy and inability to be administered without stopping work. This project aims to investigate how speech can be used to monitor changes in performance resulting from sleep deprivation and successive night shifts. The expected outcomes are 1) new knowledge on how sensitive speech and language features are for detecting change in alertness, and 2) development and verification of a highly accurate, cost-effective, speech focussed assay capable of detecting impaired alertness from otherwise healthy individuals. The project should benefit the way fitness for duty is tested and provide new methods for safeguarding Australians working in at-risk environments.Read moreRead less