Improving Treatment Strategies For Chronic Alphaviral Arthritic Diseases
Funder
National Health and Medical Research Council
Funding Amount
$643,624.00
Summary
Chikungunya virus and Ross River virus cause epidemics of acute and chronic arthritic disease in humans, which is often poorly managed with current treatments. This grant seeks to understand the mechanisms that give rise to disease in order to identify improved treatment strategies. Both the persistence of viral replication in joint tissues and unnecessary inflammatory responses appear to be important factors driving chronic disease.
Testosterone Intervention For The Prevention Of Diabetes Mellitus In High Risk Men: A Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$5,054,654.00
Summary
Type 2 diabetes (T2DM) is increasingly common, costly and deadly. Some men at risk of T2DM have low testosterone (T) levels. Our preliminary data suggests that T treatment may prevent the development of T2DM, and improve cardiovascular and sexual function, body composition and bone density, and mood. This remains to be fully tested in a randomized placebo-controlled trial, and this project will do so in a 2-year study of T treatment compared to placebo in men at risk of T2DM participating in a l ....Type 2 diabetes (T2DM) is increasingly common, costly and deadly. Some men at risk of T2DM have low testosterone (T) levels. Our preliminary data suggests that T treatment may prevent the development of T2DM, and improve cardiovascular and sexual function, body composition and bone density, and mood. This remains to be fully tested in a randomized placebo-controlled trial, and this project will do so in a 2-year study of T treatment compared to placebo in men at risk of T2DM participating in a lifestyle program.Read moreRead less
Novel Insights Into The Mechanisms Of How Viruses Cause Arthritis/Arthralgia
Funder
National Health and Medical Research Council
Funding Amount
$78,187.00
Summary
Viruses cause many diseases today and new viruses emerge to post threats to future health and well being. The proposed work investigates how viruses cause disease in people, particularly how viral infections can lead to arthritis or muscle pain. This understanding will be used in the development of new prevention strategies and treatments.
Targeting the host lipid environment to disrupt malaria transmission. This project aims to characterise host molecules (in particular lipids) that are crucial for the transition of malaria parasites from one host to another. Malaria parasites encounter different environments upon their transition from human to the mosquito host. This project expects to generate new knowledge on physiological changes that are triggered by particular differences in micronutrient abundance that allow the parasites ....Targeting the host lipid environment to disrupt malaria transmission. This project aims to characterise host molecules (in particular lipids) that are crucial for the transition of malaria parasites from one host to another. Malaria parasites encounter different environments upon their transition from human to the mosquito host. This project expects to generate new knowledge on physiological changes that are triggered by particular differences in micronutrient abundance that allow the parasites to survive in the new host. Anticipated outcomes include the identification of new intervention strategies and improved transmission model systems for vector-borne diseases. This gained knowledge could provide benefits to future biomedical applications by informing diagnostics or treatment of lipid associated diseases.Read moreRead less
Iron sources and cycling in the Tasman Sea. Determining factors that influence the health and vitality of coastal and open-ocean regions is crucial to maintaining marine biodiversity and the Earth's climatic balance. This research project will determine the role iron plays in influencing phytoplankton growth, which ultimately regulates the drawdown of carbon dioxide by the oceans.
A new approach to the U-series dating of fossil molluscs - a major advance for the earth and archaeological sciences. The development of a reliable method for accurately determining the age of fossil shells represents a breakthrough in the ability to date marine shoreline, lake, and other shell-bearing deposits (e.g. middens). This will present new opportunities for research of significant national benefit, particularly into the effects of climate change, including linked sea-level change and me ....A new approach to the U-series dating of fossil molluscs - a major advance for the earth and archaeological sciences. The development of a reliable method for accurately determining the age of fossil shells represents a breakthrough in the ability to date marine shoreline, lake, and other shell-bearing deposits (e.g. middens). This will present new opportunities for research of significant national benefit, particularly into the effects of climate change, including linked sea-level change and melting of ice sheets, the impact of sea-level change on coastal zones, and shifts in the amount and variability of rainfall in different regions. The method may also be used to estimate the frequency and size of large storm and tsunami events, earthquake risk, and the timing of prehistoric human migration and associated environmental impacts. Read moreRead less
Atmospheric CO2, global temperature, and surface ocean acidity response to fossil carbon burning - insights from an ancient analogue. Sequestration of anthropogenic CO2 emissions by the oceans and the impacts of resulting ocean acidification and greenhouse warming upon marine ecosystems are vital to understanding the course of future environmental change. This research will improve knowledge of the biological and chemical responses in the ocean to past changes in atmospheric CO2 levels and incre ....Atmospheric CO2, global temperature, and surface ocean acidity response to fossil carbon burning - insights from an ancient analogue. Sequestration of anthropogenic CO2 emissions by the oceans and the impacts of resulting ocean acidification and greenhouse warming upon marine ecosystems are vital to understanding the course of future environmental change. This research will improve knowledge of the biological and chemical responses in the ocean to past changes in atmospheric CO2 levels and increased ocean acidity. This will assist in predicting the consequences of different fossil fuel burning scenarios for climate and marine life, especially the future viability of organisms like corals, molluscs, and calcareous plankton that underpin key tourism and marine production systems.Read moreRead less
The Southern Ocean's role in determining atmospheric CO2 levels: new insights from novel biogenic silica records of seawater pH. About half the emissions from the burning of fossil fuel since the Industrial Revolution have been absorbed by the oceans. However, considerable uncertainty surrounds the consequences of and the extent to which the oceans will continue to sequester CO2 into the future. This research will improve existing limited knowledge of the key biological and related ocean process ....The Southern Ocean's role in determining atmospheric CO2 levels: new insights from novel biogenic silica records of seawater pH. About half the emissions from the burning of fossil fuel since the Industrial Revolution have been absorbed by the oceans. However, considerable uncertainty surrounds the consequences of and the extent to which the oceans will continue to sequester CO2 into the future. This research will improve existing limited knowledge of the key biological and related ocean processes that transfer CO2 between the surface and depth, and the poorly understood effects on marine ecosystems of increasing ocean acidity due to CO2 absorption. This knowledge will contribute to predicting the course of future climate change and gauging the impacts on marine life and production systems.Read moreRead less
DEEP SEA CORALS AS HIGH RESOLUTION RECORDERS OF SOUTHERN OCEAN NUTRIENT CHEMISTRY AND CIRCULATION. There is compelling evidence that the Earth has been warming dramatically since the end of the 19th century as a consequence of increasing atmospheric CO2. This study aims to understand the long-term role of the Southern Ocean as a 'store-house' for CO2, and its significance in controlling changes in the Earth's climate. We will use coral skeletons from the deep oceans as archives of ocean circu ....DEEP SEA CORALS AS HIGH RESOLUTION RECORDERS OF SOUTHERN OCEAN NUTRIENT CHEMISTRY AND CIRCULATION. There is compelling evidence that the Earth has been warming dramatically since the end of the 19th century as a consequence of increasing atmospheric CO2. This study aims to understand the long-term role of the Southern Ocean as a 'store-house' for CO2, and its significance in controlling changes in the Earth's climate. We will use coral skeletons from the deep oceans as archives of ocean circulation and nutrient levels. This information will help unravel how biological activity in the Southern Ocean has responded during previous episodes of climate change, and how this has controlled the levels of CO2 in the Earth's atmosphere. This will provide a better understanding of greenhouse warming and its effect on our future climate.Read moreRead less