The Role Of Susceptibility Genes And Microbiota In Inflammatory Diseases
Funder
National Health and Medical Research Council
Funding Amount
$303,924.00
Summary
Utilising my background in Immunology I will investigate whether specific genetic mutations can create a susceptibility for dysregulation of the flora and immune system within the gut, thus predisposing an individual to inflammatory bowel diseases (ulcerative colitis and Crohn's disease) as well as non-intestinal inflammatory conditions. These diseases are becoming an increasingly prevalent and serious health burden in Australia. We aim to use this knowledge in order to design specific treatment ....Utilising my background in Immunology I will investigate whether specific genetic mutations can create a susceptibility for dysregulation of the flora and immune system within the gut, thus predisposing an individual to inflammatory bowel diseases (ulcerative colitis and Crohn's disease) as well as non-intestinal inflammatory conditions. These diseases are becoming an increasingly prevalent and serious health burden in Australia. We aim to use this knowledge in order to design specific treatments for these diseases.Read moreRead less
The Impact Of Musculoskeletal Disorders On An Australian Population
Funder
National Health and Medical Research Council
Funding Amount
$321,275.00
Summary
A significant proportion of the Australian population experiences pain and disability as a result of musculoskeletal disorders. This research examines a wide range factors related to these conditions and focuses on the knowledge of musculoskeletal disorders and the impact of musculoskeletal conditions on the population. The answers obtained from this research have the potential to positively and significantly impact on the lives of those with musculoskeletal conditions.
Structural And Functional Studies Of The Human IL-3 Receptor
Funder
National Health and Medical Research Council
Funding Amount
$307,946.00
Summary
This proposal will study a protein hormone that is implicated in blood cell cancers and inflammatory diseases and for which current treatments are inadequate. We will determine how the hormone receptor becomes activated, identify and characterise new agents that block this activation. This information will help in the development of new and highly specific drugs for use in certain cancers in inflammatory diseases.
Role For Dipeptidyl Peptidase-IV In The Innate Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$302,123.00
Summary
The innate immune system is the bodyÍs first line of defence in fighting off infections by invading organisms. An inappropriate innate immune response can lead to the development of several inflammatory conditions such as inflammatory bowel disease. A malfunctioning innate immune response has been identified in children with IBD. This project will determine the role of a unique enzyme called DPIV in the development of innate immune responses and its potential as a therapeutic target for IBD.
Isolation And Pre-clinical Evaluation Of Small Molecule Anti-inflammatory Compounds From Hookworms
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
This project will harness the unique ability of hookworm small molecules (<10 kDa) to modulate inflammation, and exploit these properties to develop novel modalities to treat inflammatory bowel diseases, using millennia of host-parasite coevolution as a guide. The excretory/secretory and somatic extracts will be assessed for their anti-inflammatory properties using TNBS mouse model. Compounds will be separated using HPLC and identified using MS and NMR spectroscopy.
Therapeutic Potential Of Hookworm Secreted Molecules For The Treatment Of Human Autoimmune Diseases
Funder
National Health and Medical Research Council
Funding Amount
$93,597.00
Summary
In developed countries, the increased incidence of allergic and autoimmune diseases has been related to the decreased prevalence of parasitic infections. The present research will explore the role that parasite molecules play in mechanisms that regulate the immune response of their vertebrate hosts and test their potential to become novel therapeutics for the treatment of inflammatory diseases.