Using molecular tools to understand and control the transmission of Cryptosporidium. Cryptosporidium is the major public health concern of water utilities as the parasite has a global impact on the health and survival of millions of people and animals worldwide. It is resistant to chlorine and there are no effective drugs against it. Control strategies therefore rely on understanding how it is transmitted. This project will conduct a comprehensive study utilising molecular tools to determine if ....Using molecular tools to understand and control the transmission of Cryptosporidium. Cryptosporidium is the major public health concern of water utilities as the parasite has a global impact on the health and survival of millions of people and animals worldwide. It is resistant to chlorine and there are no effective drugs against it. Control strategies therefore rely on understanding how it is transmitted. This project will conduct a comprehensive study utilising molecular tools to determine if the Cryptosporidium in humans is the same as that derived from water contamination sources (animals, sewage etc). The outcomes of this project will result in the development of more targeted, cost-effective preventive measures to minimize exposures to infections, accurate risk assessment, and scientific management of the watershed.Read moreRead less
Risks to human health and the ecosystem from feral pigs in Perth metropolitan water catchments. This project aims to investigate the potential risk feral pigs pose to public health through the dissemination of water borne pathogens within water catchment areas, and to investigate their role in the maintenance and spread of diseases of public and animal health concern in the south west of Western Australia. As well as providing a frontline approach to protecting our water supplies, this project ....Risks to human health and the ecosystem from feral pigs in Perth metropolitan water catchments. This project aims to investigate the potential risk feral pigs pose to public health through the dissemination of water borne pathogens within water catchment areas, and to investigate their role in the maintenance and spread of diseases of public and animal health concern in the south west of Western Australia. As well as providing a frontline approach to protecting our water supplies, this project will also provide valuable data on the nature and extent of the risk feral pigs pose to biodiversity conservation and the environment generally. The outcomes of this research will provide a scientific basis for the development of prioritised strategies for the control of feral pigs in Western Australia.Read moreRead less
Innovative approaches to understanding and limiting the public health risks of Cryptosporidium and Giardia in animals in Australian catchments. Sophisticated molecular typing and modelling will be used to determine if chlorine-resistant parasites in animals in catchments are responsible for infection in humans. Improved catchment management and risk mitigation strategies will be developed during this project, which will make a substantial contribution to the provision of safe drinking water acro ....Innovative approaches to understanding and limiting the public health risks of Cryptosporidium and Giardia in animals in Australian catchments. Sophisticated molecular typing and modelling will be used to determine if chlorine-resistant parasites in animals in catchments are responsible for infection in humans. Improved catchment management and risk mitigation strategies will be developed during this project, which will make a substantial contribution to the provision of safe drinking water across Australia.Read moreRead less
Eliminating HCV: Statistical Modelling And Health Economic Evaluation In The New DAA Era
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
While new generation hepatitis C virus (HCV) treatments are highly efficacious, their high cost means multi-pronged approaches will be needed to reach elimination targets. This project will use statistical and mathematical modelling to inform real world health economic evaluations determine the most cost-effective response. This will inform health policy in Australia and globally.
Economic, social and cross cultural issues in non-pharmaceutical protection of front line responders to pandemic influenza and emerging infections. The protection of front line responders in a pandemic is essential to underpin an effective response. This research is the only work internationally which will address a key gap in evidence. This research has major implications for the national stockpile and for management of front line responders in a pandemic. These data are urgently needed, not ju ....Economic, social and cross cultural issues in non-pharmaceutical protection of front line responders to pandemic influenza and emerging infections. The protection of front line responders in a pandemic is essential to underpin an effective response. This research is the only work internationally which will address a key gap in evidence. This research has major implications for the national stockpile and for management of front line responders in a pandemic. These data are urgently needed, not just in Australia, but globally to inform pandemic planning and disease control policy around emerging infections and bioterrorism.Read moreRead less
Using mathematical modelling to inform HIV/AIDS public health policy. This research will directly inform HIV/AIDS policy officials on the most effective strategies for preventing new cases in HIV in the community. Consequently, there are health benefits for Australia and for the other countries in which the research is being conducted. HIV/AIDS community groups, educators, and other advocacy groups will also be engaged in the research, leading to the development of focussed prevention campaigns ....Using mathematical modelling to inform HIV/AIDS public health policy. This research will directly inform HIV/AIDS policy officials on the most effective strategies for preventing new cases in HIV in the community. Consequently, there are health benefits for Australia and for the other countries in which the research is being conducted. HIV/AIDS community groups, educators, and other advocacy groups will also be engaged in the research, leading to the development of focussed prevention campaigns by these stakeholders to inform the appropriate communities. Reducing the health burdens of HIV/AIDS will also have economic benefits.Read moreRead less
Combating Infectious Diseases: Eco-Epidemiology, Disease Mapping, And Travel Medicine
Funder
National Health and Medical Research Council
Funding Amount
$344,644.00
Summary
Infectious disease outbreaks are driven by complex interactions between humans, animals, vectors, and the environment. Globally, outbreaks have been increasing in frequency and magnitude, e.g. Ebola and SARS. There is an urgent need to improve public health intelligence by accurately identifying the causes, timing, and hotspots. This project will develop advanced modelling strategies for improving our understanding of outbreaks, and optimise public health interventions to protect human health.
Post-genomic Surveillance For Communicable Disease Control
Funder
National Health and Medical Research Council
Funding Amount
$470,144.00
Summary
Genomic surveillance is now at the forefront of translational research due to recent significant advances in genomics and informatics, increasing demands for rapid detection of outbreaks and transformational impact of culture-independent testing on public health. This multi-disciplinary research will redefine existing paradigms, develop and evaluate novel systems for laboratory surveillance and offer insights into transmission dynamics of high-burden pathogens for Australia.
Tuberculosis In The Asia-Pacific: Identification And Comparison Of Transmission Hot Spots
Funder
National Health and Medical Research Council
Funding Amount
$120,253.00
Summary
The Asia-Pacific is home to 60% of the global burden of tuberculosis and an increasing proportion of Australia's immigrant population. Although most targets relating to this disease are likely to be achieved, patterns of tuberculosis transmission in the Asia-Pacific are not fully understood and the possibility of regional hotspots exists. We aim to use mathematical techniques to examine the way in which tuberculosis is transmitted from person to person in populations within our region.