Modern Chemical Exposures In Utero And In Infancy, And Their Impact Upon Early Neurodevelopmental Outcomes In The Barwon Infant Study, An Unselected Birth Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$138,353.00
Summary
I am a paediatric doctor interested in the effects of modern industrial chemicals on children’s development. Even in the womb babies are exposed to industrial chemicals and we know some, like lead, are harmful to developing brains. I am interested in other chemicals that are now suspected to affect development, including the polybrominated diphenyl esters (PBDEs), and I intend to investigate this as part of the Barwon Infant Study, which follows 1250 children from before birth to 3 years.
A Randomised Trial Of An Early Parenting Intervention To Reduce Maternal Mood Disorder And Infant Behavior Disturbance
Funder
National Health and Medical Research Council
Funding Amount
$390,503.00
Summary
Over 242,000 women give birth annually in Australia and up to 20% experience significant psychological distress in the baby's first year. Severe fatigue, worrying and depression interfere with the development of maternal confidence. If a baby does not sleep well or feed easily or cries for prolonged periods, mothers can feel ineffective and helpless. Assistance early in the baby's life is important to avoid long-term emotional and behavioral problems for mother and child. Nationally, health and ....Over 242,000 women give birth annually in Australia and up to 20% experience significant psychological distress in the baby's first year. Severe fatigue, worrying and depression interfere with the development of maternal confidence. If a baby does not sleep well or feed easily or cries for prolonged periods, mothers can feel ineffective and helpless. Assistance early in the baby's life is important to avoid long-term emotional and behavioral problems for mother and child. Nationally, health and social policy focuses on assisting families including those with parental mental health and early parenting problems and children at risk of developmental difficulties. Australia's residential early parenting services are unique, offering brief treatment to mothers with difficulties and infants with unsettled behaviour. Parents are educated in infant care and provided with emotional support and assistance to adjust to the demands of parenting. In past studies by CIA and CIB women reported marked improvements in emotional distress, maternal confidence and infant manageability after completing this treatment and six months later. The education and emotional support were rated as acceptable and very effective. This project is a randomized controlled trial that will evaluate whether brief admission to a residential early parenting service has sustainable benefits for mild to moderate maternal mental health problems and for infant behaviour disturbance. Mothers with a diagnosable mental health condition and with four-month-old infants reported to have unsettled infant behaviour will be randomly assigned to a residential treatment program at an early parenting service or to routine care. Mothers and infants will be assessed with standardized psychological measures one month after treatment and when the baby is one year old. An effective and acceptable intervention will provide an important alternative to available treatments for postnatal psychological disturbance.Read moreRead less
Infant Motor Development Between 0-4 Months: A New Look At The Effect Of The ‘back To Sleep’ Program
Funder
National Health and Medical Research Council
Funding Amount
$107,182.00
Summary
An unexpected consequence of the Back to Sleep program is an increased incidence of deformational plagiocephaly (DP), or “flat head syndrome”, and concern about delayed development. It is not clear whether the current recommendation to provide ‘tummy-time’ play for infants when awake is the best way to prevent DP. Development of typical infants 0-4 months and infants with DP will be investigated and parents surveyed as a basis for development and trialling of a new DP prevention initiative.
We are an international team committed to clinical trials to improve survival without disability in newborn babies. We plan a randomised trial to confirm if bovine lactoferrin, an inexpensive dairy protein, reduces death or major morbidity and increases total breast milk intake in 1,500 very low birthweight babies in neonatal intensive care units
Best Fed: Implementing Evidence Based Clinical Practice Guidelines To Improve Breast Milk Use And The Feeding Management Of Infants Born
Funder
National Health and Medical Research Council
Funding Amount
$177,197.00
Summary
Breast milk is the best food for babies born prematurely. There are challenges for women in providing breast milk and challenges for clinicians in managing the feeds of preterm babies, including when to start feeds and how quickly to progress. Sometimes research evidence doesn’t translate into practice and in this project I will support clinicians to implement the best evidence so that more preterm babies are receiving breast milk on discharge home.
A Randomised Controlled Trial Of Enhanced Parenting Capacity To Improve Developmental Outcomes In Preterm Infants
Funder
National Health and Medical Research Council
Funding Amount
$1,045,141.00
Summary
In Australia there are 2, 600 very preterm survivors each year. 50% will have education/behavioural difficulties and 10% major disability. We aim to optimise the development of infants born very preterm through a tailored Positive Parenting Program. We predict reductions in child behavioural and emotional problems at 2 years corrected age.
Good nutrition is a vital element in a healthy start to life. Determining the correct foods to ensure that pregnant women meet both their needs as well as those of their new baby can be very confusing. Do I need to take iron supplements? How can I ensure I get enough iodine? This project will develop new methods for evaluating the effects of nutrients and to pass that information on to health practitioners so that Australian mothers will be in no doubt about the best diet for them and their chil ....Good nutrition is a vital element in a healthy start to life. Determining the correct foods to ensure that pregnant women meet both their needs as well as those of their new baby can be very confusing. Do I need to take iron supplements? How can I ensure I get enough iodine? This project will develop new methods for evaluating the effects of nutrients and to pass that information on to health practitioners so that Australian mothers will be in no doubt about the best diet for them and their children.Read moreRead less
Docosahexaenoic Acid For The Reduction Of Bronchopulomonary Dysplasia In Preterm Infants Born At Less Than 29 Weeks Gestational Age: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,929,854.00
Summary
A major challenge in the care of very preterm babies, is dealing with the fact that the baby has very immature lungs. They are prone to an inflammatory condition known as BPD (broncho-pulmonary dysplasia) that prevents an infant from breathing, much like asthma in older children. This can result in poor health outcomes for life. Our study will test the effect of the omega 3 fat known as DHA in reducing this inflammation in the lung and result in better outcomes for the baby.
DHA For The Improvement Of Neurodevelopmental Outcome In Preterm Infants: The DINO Trial
Funder
National Health and Medical Research Council
Funding Amount
$631,875.00
Summary
The incidence of neurological problems that occur in children born prematurely is higher than for those born at term. The earlier that a baby is born, the greater chance it has of having some developmental delay and general inability to cope at school. This has implications for the child, the families and the health system. One of the many dietary factors implicated in the development of neural abilities in premature infants is an omega-3 fatty acid called DHA. This compound is present in breast ....The incidence of neurological problems that occur in children born prematurely is higher than for those born at term. The earlier that a baby is born, the greater chance it has of having some developmental delay and general inability to cope at school. This has implications for the child, the families and the health system. One of the many dietary factors implicated in the development of neural abilities in premature infants is an omega-3 fatty acid called DHA. This compound is present in breast milk and most preterm formulas and is found in high concentrations in the brain and retina. In the last third of pregnancy the developing baby would normally accumulate DHA at a rapid rate. So it seems reasonable to assume that a baby outside the mother, that is born premature, would also need to accumulate DHA at this same rate. The problem is that none of the milks currently given to premature infants have DHA in high enough concentration to supply this amount of DHA to the baby. For example, breast milk and preterm formulas contain only a third of the DHA required. In order to provide this amount for the premature infant, breast milk containing DHA at about 1% of the total fat is required. Fortunately the level of DHA in breast milk can be increased to this level by supplementing the mothers diet with fish or olis like tuna oil. This study hopes to show that premature babies who receive DHA in amounts similar to that supplied in the womb will develop better than babies who receive low amounts of DHA.Read moreRead less