Environmental Influences In The Establishment Of The Epigenetic Landscape In Children
Funder
National Health and Medical Research Council
Funding Amount
$695,097.00
Summary
The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells ....The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells use epigenetic changes to help control how they grow and develop. Evidence suggests a direct link between diet and environmental influences on our epigenetic profile. Recent research has traced the origins of many of the health problems of adult life back to the earliest periods of development _ to the time spent in the womb and the first few years of life. If we are born with a low birth weight, we are more likely to get sick later in life. Overwhelming evidence exists that the environment in the womb is critical for a healthy birth weight (and health in later life) and it is thought that epigenetics may be the missing link between this environment, low birth weight, and therefore health in later life. In addition, mounting evidence supports a general link between epigenetic de-regulation and predisposition to disease. However, the timing and the overall contribution of environmental- genetic influences to the establishment of faulty epigenetic markings remain largely unknown. Twins are the best model to study this link as they share similar (but not identical environments) and some share identical genetic makeup. Using twins, Dr Jeffrey Craig and his team will investigate the factors in the prenatal environment that modify specific cells, leading to low birth weight and increase disease risk later in life. They predict that this occurs via specific changes in gene activity caused by epigenetic disruption.Read moreRead less
Mental Health Across Generations: Pre-and Post Conception Predicators Of Early Life Risks
Funder
National Health and Medical Research Council
Funding Amount
$666,231.00
Summary
In 2003, mental illnesses were among the ten leading causes of disease burden in Australia, accounting for 13% of the total burden of disease, according to the Australian Institute of Health and Welfare. Mental health problems and mental illness are among the greatest causes of disability, diminished quality of life, and reduced productivity. People affected by mental health problems often have high levels of morbidity and mortality, experiencing poorer general health and higher rates of death f ....In 2003, mental illnesses were among the ten leading causes of disease burden in Australia, accounting for 13% of the total burden of disease, according to the Australian Institute of Health and Welfare. Mental health problems and mental illness are among the greatest causes of disability, diminished quality of life, and reduced productivity. People affected by mental health problems often have high levels of morbidity and mortality, experiencing poorer general health and higher rates of death from a range of causes, including suicide. These conditions are significant in terms of prevalence and disease burden, and have far-reaching impacts for families, carers and others in the community. Mental health problems commonly cluster in families. However, few studies have previously been able to investigate the range of ways in which mental disorders may pass from one generation to another. Further, evidence suggests that influences that arise prior to conception may have major effects on early life risks such as development in utero, birth outcomes and early maternal infant bonding. Mental Health across Generations: Pre- and post-conception predictors of early life risks is a unique study that will examine antenatal maternal mental health and risk behaviours during pregnancy. The study will also examine the links between prior maternal mental health and later birth outcomes, and post natal maternal infant bonding. The risk processes to be tested will include genetic, epigenetic (changes in gene expression), physiological and psycho-social parameters.Read moreRead less
A Multi-setting Intervention To Reduce Sedentary Behaviour, Promote Physical Activity And Improve Childrens Health
Funder
National Health and Medical Research Council
Funding Amount
$860,343.00
Summary
Sedentary behaviours and physical inactivity play a major role in the rising prevalence of obesity among children in Australia. This intervention study will take place in the school and family settings which play a critical role in shaping children's health behaviours. The objective is to determine whether a 2-year behavioural intervention reduces sedentary behaviour and promotes physical activity and results in improved health among 8-9 year old children.
Centre Of Research Excellence On Sitting Time And Chronic Disease Prevention – Mechanisms, Measurement And Interventions
Funder
National Health and Medical Research Council
Funding Amount
$2,657,874.00
Summary
Australian research has identified serious health consequences arising from the 7 to 10 hours of daily sitting that most people do, especially in relation to ‘diseases of inactivity’ – type 2 diabetes, coronary heart disease and breast and colon cancer – that are an unwelcome burden on individuals, families and health systems. This new research examines the practical feasibility and the preventive-health benefits of changing children’s and adults’ sitting time in schools, workplaces and the home ....Australian research has identified serious health consequences arising from the 7 to 10 hours of daily sitting that most people do, especially in relation to ‘diseases of inactivity’ – type 2 diabetes, coronary heart disease and breast and colon cancer – that are an unwelcome burden on individuals, families and health systems. This new research examines the practical feasibility and the preventive-health benefits of changing children’s and adults’ sitting time in schools, workplaces and the home environment.Read moreRead less
Sitting Less And Moving More: Population Health Research To Understand And Influence Sedentary Behaviour
Funder
National Health and Medical Research Council
Funding Amount
$6,367,518.00
Summary
The majority of Australian adults spend most of their waking hours sitting: at home, at work, and in their cars; most do not participate in exercise or sport. This leads to weight gain and to diseases of inactivity (particularly diabetes, heart disease, cancer and depression). New research will measure sitting time and the physical activity in people's daily lives, what factors encourage inactivity, and how to increase activity levels, especially among the ageing 'baby boomer' population.
Serving the greater good: using 'Servant Leadership' to build ethical and engaging work practices. The project will result in the first organisational application in Australia of a leadership development program based on scientific foundations of the 'Servant Leadership' framework. The outcomes will benefit organisations of all types in developing the leadership capabilities required to create ethical, positive, and sustainable work environments.
Discovery Early Career Researcher Award - Grant ID: DE170100829
Funder
Australian Research Council
Funding Amount
$353,000.00
Summary
The effects of parental education on child health outcomes. This project aims to understand how public education policies can improve health. Common economic analysis of returns to education fails to capture the critical secondary beneficial effects of parental education on future generations’ health. These positive effects are systematically undercounted in the cost-benefit analysis of Australia’s investment in education. This project will use Australian datasets and natural experiments to iden ....The effects of parental education on child health outcomes. This project aims to understand how public education policies can improve health. Common economic analysis of returns to education fails to capture the critical secondary beneficial effects of parental education on future generations’ health. These positive effects are systematically undercounted in the cost-benefit analysis of Australia’s investment in education. This project will use Australian datasets and natural experiments to identify how parental education affects the health outcomes of the second generation. This project expects to provide policy recommendations to maximise health, wellbeing and economic outcomes for Australia.Read moreRead less
The Aging Population, Superannuation and Corporate Dividend Policy. The project intends to examine how population wealth and age affect one important aspect of corporate decision-making, namely dividend policy. Researchers invest considerable effort in understanding how demographics impact upon the need for, and structure of, government systems including social security and taxation, but relatively little is known about its effect on capital markets or corporate decision-making. Although individ ....The Aging Population, Superannuation and Corporate Dividend Policy. The project intends to examine how population wealth and age affect one important aspect of corporate decision-making, namely dividend policy. Researchers invest considerable effort in understanding how demographics impact upon the need for, and structure of, government systems including social security and taxation, but relatively little is known about its effect on capital markets or corporate decision-making. Although individual investors are, by nature, atomistic, the project argues changes in investor preferences will ultimately prompt companies to alter their dividend policies. Pressure on firms to update these policies will come from superannuation and pension fund managers who, as fiduciaries, will invest money consistent with clients' revised preferences. The project aims to more fully characterise how Australia's ageing population will affect the public and private sectors.Read moreRead less
A Randomised Trial Of The Augmentation Of Cognitive Behaviour Therapy With Fluoxetine For Anxious School Refusing Youth
Funder
National Health and Medical Research Council
Funding Amount
$539,191.00
Summary
School refusing youth consistently suffer from anxiety and sometimes depression. They become severely emotionally distressed when taken to school and experience social and academic difficulties in the short and long term as well as psychiatric illness in adulthood. Our program investigates whether treatment can be improved by enhancing psychotherapy (cognitive behaviour therapy) which helps over half of anxious school refusing children, with antidepressant-anxiety medication compared to placebo.
Development of psychological capital in emergency service organisations. The project addresses the research priorities ‘Promoting good health and well being for all Australians’ and Safeguarding Australia. The project will identify ways in which the performance and wellbeing of volunteer and paid members of emergency service organisations can be enhanced, potentially diminishing the likelihood of depression, aggression, and other detrimental effects. The findings will also contribute to the qual ....Development of psychological capital in emergency service organisations. The project addresses the research priorities ‘Promoting good health and well being for all Australians’ and Safeguarding Australia. The project will identify ways in which the performance and wellbeing of volunteer and paid members of emergency service organisations can be enhanced, potentially diminishing the likelihood of depression, aggression, and other detrimental effects. The findings will also contribute to the quality of training provided to leaders in emergency services. Theoretically, the project will advance understanding of the mechanisms that underpin the psychological capital construct, placing Australian researchers at the forefront of this important emerging field of inquiry.Read moreRead less