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Long-term Follow-up Of Children Born Preterm Who Received High Dose DHA: The DINO Trial Follow-up.
Funder
National Health and Medical Research Council
Funding Amount
$725,972.00
Summary
Children born prematurely are more likely to need help at school and to repeat a grade. One of the factors that may be responsible for the poor development of children who were premature may be the lack of an omega-3 fatty acid, called DHA. We have done a study in which feeds of premature infants were supplemented with DHA at a level equivalent to what a baby would recieve in the womb. We now want to see if these children have improved development at school age.
Perth Aboriginal Breast Feeding Study: Reasons For Not Breast Feeding And For The Early Cessation Of Breast Feeding.
Funder
National Health and Medical Research Council
Funding Amount
$207,237.00
Summary
Perth Aboriginal Breast Feeding Study : Reasons for not Breast Feeding and for the Early Cessation of Breast Feeding. Breastfeeding has many advantages for the nutrition and health of infants and mothers. Recent research has shown the importance of longitudinal studies of breast feeding and the importance of family support systems, especially the attitude of the baby's father. In urban Aboriginal families the rate of breast feeding is lower and the duration is shorter than for those living in ru ....Perth Aboriginal Breast Feeding Study : Reasons for not Breast Feeding and for the Early Cessation of Breast Feeding. Breastfeeding has many advantages for the nutrition and health of infants and mothers. Recent research has shown the importance of longitudinal studies of breast feeding and the importance of family support systems, especially the attitude of the baby's father. In urban Aboriginal families the rate of breast feeding is lower and the duration is shorter than for those living in rural areas. There have been no longitudinal studies exploring the factors involved in the initiation and the continuation of breast feeding by Aboriginal women. A sample of 440 Aboriginal women will be recruited from Perth maternity hospitals. After an initial interview the women will be followed up at monthly intervals to find out their progress with breast feeding. In addition a number of focus group discussions will explore attitudes of Aboriginal women and men to breast feeding. The outcome of the studies will be information to feed back to the community through Aboriginal organisations. It will provide the basis for specifically targeted health promotion programs to maintain and to improve breast feeding rates in the Aboriginal community.Read moreRead less
Early Introduction Of Foods Into Infant Weaning Diets To Induce Oral Tolerance And Prevent Food Allergies.
Funder
National Health and Medical Research Council
Funding Amount
$143,660.00
Summary
Food allergies can be life threatening, and with no treatment, prevention is crucial. Traditional advice for babies whose parents have allergies has been to delay the introduction of allergy causing foods. However, recent research has questioned this approach. In this study I plan to investigate whether the early introduction of fish and eggs in the weaning diet can reduce the incidence of allergy. The results will be crucial to determine the best approach to reduce the risk of food allergy.
Transcriptional Regulation Of Gene Expression: Dietary Sialic Acid Interaction In Brain Cognitive Development
Funder
National Health and Medical Research Council
Funding Amount
$46,646.00
Summary
In 2004, 8.2% of Australian live births were preterm with poor long-term cognitive outcomes. Sialic acid (SA), a key component of both human milk oligosaccharides and neural tissues, plays a role in neuronal development. This study will examine the mechanisms of how dietary SA or active learning interacts with genes during brain development. It will benefit the neonatal care of all children, particularly those born premature and ultimately, the quality of life of many Australians.
THE ROLE OF SIALIC ACID IN INFANT NUTRITION AND BRAIN DEVELOPMENT
Funder
National Health and Medical Research Council
Funding Amount
$402,750.00
Summary
Sub-optimal nutrition during critical periods of brain growth has persistent effects on the human brain. Premature infants are especially vulnerable because brain growth reaches its peak at 26 weeks gestation and remains high throughout the first year of life. Those fed human milk in the first month after birth have been shown to have a significant intellectual advantage compared with infants fed standard infant formulas. While the n-3 fatty acids such as DHA are thought to be important, other c ....Sub-optimal nutrition during critical periods of brain growth has persistent effects on the human brain. Premature infants are especially vulnerable because brain growth reaches its peak at 26 weeks gestation and remains high throughout the first year of life. Those fed human milk in the first month after birth have been shown to have a significant intellectual advantage compared with infants fed standard infant formulas. While the n-3 fatty acids such as DHA are thought to be important, other components of human milk may be of greater significance for brain growth. Our interest is in a sugar compound called sialic acid. It occurs in remarkably large amounts in human milk (up to 1g-L) but is present in only small quantities in infant formulas. Sialic acid is an important structural and functional component of brain cells. It is directly involved in nerve cell transmission, memory formation and cell-to-cell communication. During peak brain growth, young infants, especially pre-term ones, are unlikely to be able to synthesise sufficient sialic acid to meet their needs. At these times, they rely on human milk and infant formulas to supply the necessary building blocks. If their diet is a poor source of sialic acid, however, there may be lasting consequences for intellectual development. This research project addresses several questions. 1. Does oral sialic acid supplementation over the first few weeks of life increase both brain sialic acid levels as well as learning behaviour? 2. Is there any dose-response relationship - is more better? 3. Does supplementation influence the expression of genes encoding key enzymes in the brain? 4. Does dietary supplementation affect the activity of the liver enzyme involved in synthesis of sialic acid? If our findings can be extrapolated to human infants, they will have implications for the etiology of all types of cognitive and behavioural defects in children, including learning difficulties and attention deficit disorder.Read moreRead less