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Discovery and characterisation of novel lanthipeptide biopreservatives. The aim of this project is to advance fundamental knowledge of microbial metabolism and provide natural anti-microbial molecules to the Australian food industry. A quarter of the world’s food supply is lost because of microbiological spoilage. Some chemical preservatives have been developed to combat food spoilage organisms, however their chronic impact on human health is the subject of debate. Consumer demand for safe and n ....Discovery and characterisation of novel lanthipeptide biopreservatives. The aim of this project is to advance fundamental knowledge of microbial metabolism and provide natural anti-microbial molecules to the Australian food industry. A quarter of the world’s food supply is lost because of microbiological spoilage. Some chemical preservatives have been developed to combat food spoilage organisms, however their chronic impact on human health is the subject of debate. Consumer demand for safe and natural alternatives is growing. Paradoxically, microbially-produced bioactive peptides may be the key to combating food spoilage organisms and food-borne pathogens. To this end, the project intends to develop an innovative strategy for the discovery, biosynthesis and characterisation of novel anti-microbial lanthipeptides.Read moreRead less
Synthetic phenazines for enhanced biogas production from renewable and non-renewable resources. Methane (biogas) has a large role to play in meeting the energy needs of the human race globally whilst reducing greenhouse gas emissions. Microbial communities are responsible for biogas production from non-renewable (coal) and renewable (food waste) resources. This project seeks to: increase biogas yields by redirecting electron flow towards biogas producing microbes using electrochemically active p ....Synthetic phenazines for enhanced biogas production from renewable and non-renewable resources. Methane (biogas) has a large role to play in meeting the energy needs of the human race globally whilst reducing greenhouse gas emissions. Microbial communities are responsible for biogas production from non-renewable (coal) and renewable (food waste) resources. This project seeks to: increase biogas yields by redirecting electron flow towards biogas producing microbes using electrochemically active phenazines; understand the molecular mechanism by which phenazines increase biogas yields; and, assess the environmental consequence of phenazine application to coal seam gas production and anaerobic digestion of food waste. Phenazines are likely to emerge as a safe and cost-effective technology for improved biogas generation.Read moreRead less
Mid-Career Industry Fellowships - Grant ID: IM230100154
Funder
Australian Research Council
Funding Amount
$1,049,904.00
Summary
Fungi Power: Designer Fungal Cell Factories for Advanced Biomanufacturing. This project aims to build an advanced biomanufacturing platform based on filamentous fungi in collaboration with industry. Using synthetic biology, the project expects to engineer superior fungal host strains customisable to the needs of the industry and to address their technological gaps. The expected outcomes include the development of cost-efficient and sustainable fungal-based bioprocesses for the companies to produ ....Fungi Power: Designer Fungal Cell Factories for Advanced Biomanufacturing. This project aims to build an advanced biomanufacturing platform based on filamentous fungi in collaboration with industry. Using synthetic biology, the project expects to engineer superior fungal host strains customisable to the needs of the industry and to address their technological gaps. The expected outcomes include the development of cost-efficient and sustainable fungal-based bioprocesses for the companies to produce products, such as fine chemicals, pharmaceutical actives and food ingredients. The project would provide significant benefits by enabling existing and emerging companies' commercial successes and competitiveness in global markets, creating new jobs and resulting in the growth of the bio-economy in Australia.Read moreRead less
Dual-membrane upgrading towards sustainable wastewater management. Water utilities in Australia have set aspirational targets for energy- and carbon-neutral wastewater services by as early as 2030. However, these two aims are often incompatible because of excessive aeration energy consumption and substantial greenhouse gas emissions in wastewater treatment plants. This project aims to develop a novel biotechnology that enables simultaneous bioenergy recovery, cost-efficient nitrogen removal and ....Dual-membrane upgrading towards sustainable wastewater management. Water utilities in Australia have set aspirational targets for energy- and carbon-neutral wastewater services by as early as 2030. However, these two aims are often incompatible because of excessive aeration energy consumption and substantial greenhouse gas emissions in wastewater treatment plants. This project aims to develop a novel biotechnology that enables simultaneous bioenergy recovery, cost-efficient nitrogen removal and mitigation of greenhouse gas emissions, thus bringing multifaceted benefits to wastewater management. The project will provide strong support to the Australian water industry in their endeavour to achieve economically and environmentally sustainable wastewater services.Read moreRead less
Understanding bacteriophage deactivation and stabilisation in formulations. Bacteriophages (phages) are viruses that kill pathogenic bacteria without causing harms to the eco-balance. They can provide a safe and highly effective antimicrobial measure for biocontrol when formulated properly. This project aims to develop a mechanistic understanding of the physicochemical factors responsible for stabilising and deactivating phages in a wide range of formulations. It will create new knowledge on ke ....Understanding bacteriophage deactivation and stabilisation in formulations. Bacteriophages (phages) are viruses that kill pathogenic bacteria without causing harms to the eco-balance. They can provide a safe and highly effective antimicrobial measure for biocontrol when formulated properly. This project aims to develop a mechanistic understanding of the physicochemical factors responsible for stabilising and deactivating phages in a wide range of formulations. It will create new knowledge on key relationships between phage chemistry, phage-excipient interactions and phage stability. The research outcomes would significantly benefit Australia by enabling commercial development in the high value-adding area of environmentally friendly antimicrobial products.Read moreRead less
Unleashing the Hidden Chemical Diversity in Australian Fungi. This project aims to exploit an exclusive genomic resource consisting of >150 unique Australian filamentous fungi that has been built in a university-industry collaboration for genomic-guided biodiscovery. The genome sequence of these fungi revealed extensive hidden genetic instructions for production of novel biologically active molecules. The project will apply cutting-edge synthetic biology and chemical tools to tap into the hidden ....Unleashing the Hidden Chemical Diversity in Australian Fungi. This project aims to exploit an exclusive genomic resource consisting of >150 unique Australian filamentous fungi that has been built in a university-industry collaboration for genomic-guided biodiscovery. The genome sequence of these fungi revealed extensive hidden genetic instructions for production of novel biologically active molecules. The project will apply cutting-edge synthetic biology and chemical tools to tap into the hidden genomic potential of these Australian fungi. Expected outcomes of this project include new fine chemicals and lead molecules with desirable bioactivies. This will provide significant benefits to Australia's economy through the discovery of new pharmaceuticals, veterinary products and agrichemicals.Read moreRead less
Using photosynthesis to power fine chemical production. This project aims to develop robust, solar driven, enzyme-based biocatalysts to synthesise complex metabolites and biopharmaceutical molecules in single-cell micro-algae. The significance of this project is that solar energy is used to drive challenging chemical reactions inexpensively via photosynthesis. Expected outcomes include sustainable, solar driven production of high-value molecules that are difficult or impossible to synthesise che ....Using photosynthesis to power fine chemical production. This project aims to develop robust, solar driven, enzyme-based biocatalysts to synthesise complex metabolites and biopharmaceutical molecules in single-cell micro-algae. The significance of this project is that solar energy is used to drive challenging chemical reactions inexpensively via photosynthesis. Expected outcomes include sustainable, solar driven production of high-value molecules that are difficult or impossible to synthesise chemically. Benefits include proof-of-principle demonstration of new, light-driven green-chemistry processes for the production of biochemicals, biopharmaceuticals, agricultural and industrial chemicals, extending the diversity of molecules we can make while reducing cost and environmental impact of their production.Read moreRead less
Engineering of a novel export system for industrially important amino acids. This project aims to understand the gating mechanism of MscCG (a major amino acid exporter) and improve the amino acid production by designing a highly effective MscCG-like export system for selective membrane transport of industrially relevant amino acids. Amino acid production is one of the most promising global markets, driven by growing meat consumption in developing countries. The project aims to elucidate the thre ....Engineering of a novel export system for industrially important amino acids. This project aims to understand the gating mechanism of MscCG (a major amino acid exporter) and improve the amino acid production by designing a highly effective MscCG-like export system for selective membrane transport of industrially relevant amino acids. Amino acid production is one of the most promising global markets, driven by growing meat consumption in developing countries. The project aims to elucidate the three-dimensional structure of MscCG and identify important parts. In doing so, the project aims to design more efficient and economic amino acid production.Read moreRead less
Development of a concentration process for thermally sensitive liquids by the integration of Osmotic Distillation with Freeze Concentration. There is a need for low temperature concentration of thermally sensitive fruit juices and biological liquids with preserved qualities and nutrients. Although Freeze Concentration has been successful up to about 40% solids, it then requires expensive freezing. This project aims to integrate Osmotic Distillation with Freeze Concentration to achieve up to ab ....Development of a concentration process for thermally sensitive liquids by the integration of Osmotic Distillation with Freeze Concentration. There is a need for low temperature concentration of thermally sensitive fruit juices and biological liquids with preserved qualities and nutrients. Although Freeze Concentration has been successful up to about 40% solids, it then requires expensive freezing. This project aims to integrate Osmotic Distillation with Freeze Concentration to achieve up to about 70% solids, for long-term storage under ambient or refrigerated conditions. If successful, the combined process would enable increased export of high quality agricultural products such as grape concentrate for wine making, as well as other liquid foods, beverages and biotechnological products.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775746
Funder
Australian Research Council
Funding Amount
$102,000.00
Summary
GC/MS facility for medical, bioanalytical and environmental research. The research will contribute to the bioremediation of heavily polluted sites in Sydney and the knowledge gained and the technology developed will be applicable to sites all over the world. Fundamental knowledge in Systems Biology will have applications to advance Australian export industries based on fermentation. Advances in chemical ecology and biotechnology will impact in areas such as contact lenses, implants, therapeutics ....GC/MS facility for medical, bioanalytical and environmental research. The research will contribute to the bioremediation of heavily polluted sites in Sydney and the knowledge gained and the technology developed will be applicable to sites all over the world. Fundamental knowledge in Systems Biology will have applications to advance Australian export industries based on fermentation. Advances in chemical ecology and biotechnology will impact in areas such as contact lenses, implants, therapeutics and water treatment. Probing pituitary hormone action will lead to greater understanding of health issues such as abnormal body composition, obesity and diabetes.Read moreRead less